The Immune System and Viral Hepatitis

Fierro, Nora A.; González-Aldaco, Karina; Román, Sonia; Panduro, Arturo

doi:10.1016/b978-0-12-804274-8.00009-6

Cited by 2 publications

(2 citation statements)

References 70 publications

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“…The study of hepatovirus has been an important issue in hepatology research in the last four decades. HBV and HCV are most studied, as they produce chronic liver damage, leading to cirrhosis and HCC[ 190 ]. As global causes of liver cirrhosis, HBV accounts for 30%, HCV for 28%, alcohol for 27% and others for 14% of cirrhosis cases.…”

Section: Antiviral Properties Of Naringeninmentioning

confidence: 99%

“…An interesting phenomenon is that HCV circulates in the blood in the form of a lipoprotein complex called lipoviroparticle (LVP); it has been reported that HCV may be associated with lipoproteins such as VLDL and low-density lipoprotein (LDL). Notably, the binding of lipoviroparticle to receptors as LDLR or SR-B1 enables the infectivity of HCV and its escape from the humoral immune response[ 190 - 193 ]. A relationship between the virion production process and lipoproteins, cholesterol, triglycerides and fatty acids has been suggested.…”

Section: Antiviral Properties Of Naringeninmentioning

confidence: 99%

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Beneficial effects of naringenin in liver diseases: Molecular mechanisms

Hernández-Aquino

Muriel

2018

WJG

264

176

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Liver diseases are caused by different etiological agents, mainly alcohol consumption, viruses, drug intoxication or malnutrition. Frequently, liver diseases are initiated by oxidative stress and inflammation that lead to the excessive production of extracellular matrix (ECM), followed by a progression to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). It has been reported that some natural products display hepatoprotective properties. Naringenin is a flavonoid with antioxidant, antifibrogenic, anti-inflammatory and anticancer properties that is capable of preventing liver damage caused by different agents. The main protective effects of naringenin in liver diseases are the inhibition of oxidative stress, transforming growth factor (TGF-β) pathway and the prevention of the transdifferentiation of hepatic stellate cells (HSC), leading to decreased collagen synthesis. Other effects include the inhibition of the mitogen activated protein kinase (MAPK), toll-like receptor (TLR) and TGF-β non-canonical pathways, the inhibition of which further results in a strong reduction in ECM synthesis and deposition. In addition, naringenin has shown beneficial effects on nonalcoholic fatty liver disease (NAFLD) through the regulation of lipid metabolism, modulating the synthesis and oxidation of lipids and cholesterol. Moreover, naringenin protects from HCC, since it inhibits growth factors such as TGF-β and vascular endothelial growth factor (VEGF), inducing apoptosis and regulating MAPK pathways. Naringenin is safe and acts by targeting multiple proteins. However, it possesses low bioavailability and high intestinal metabolism. In this regard, formulations, such as nanoparticles or liposomes, have been developed to improve naringenin bioavailability. We conclude that naringenin should be considered in the future as an important candidate in the treatment of different liver diseases.

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Section: Antiviral Properties Of Naringeninmentioning

confidence: 99%

Section: Antiviral Properties Of Naringeninmentioning

confidence: 99%

Beneficial effects of naringenin in liver diseases: Molecular mechanisms

Hernández-Aquino

Muriel

2018

WJG

264

176

View full text Add to dashboard Cite

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Особенности Обмена Липидов При HCV-инфекции

Волынец¹

2021

Клиническая Инфектология И Паразитология

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Стадии жизненного цикла вируса гепатита С (HCV) осуществляются при участии обмена липидов в клетках печени.Цель исследования: провести обзор особенностей липидного обмена в клетках печени при HCV-инфекции и его роли в формировании стеатоза печени.Результаты. Показаны влияние HCV-инфекции на обмен липидов в гепатоцитах, взаимосвязь метаболитов холестерина и иммунологического ответа на HCV-инфекцию, генетические аспекты особенностей обмена липидов при HCV-инфекции.Заключение. Метаболизм липидов имеет большое значение при HCV-инфекции. Внутрипеченочный жизненный цикл HCV сильно зависит от печеночного холестерина и путей липогенеза. Во время инфицирования HCV активирует метаболизм липидов хозяина с помощью различных молекулярных механизмов, которые могут в конечном итоге способствовать развитию стеатоза печени. The life cycle stages of the hepatitis C virus (HCV) are carried out with the participation of lipid metabolism in liver cells.Purpose: to review the features of lipid metabolism in liver cells during HCV infection and its role in the formation of hepatic steatosis.Results. The influence of HCV infection on lipid metabolism in hepatocytes, the relationship of cholesterol metabolites and the immunological response to HCV infection, genetic aspects of lipid metabolism in HCV infection are shown.Conclusion. Lipid metabolism is of great importance in HCV infection. The intrahepatic life cycle of HCV is highly dependent on hepatic cholesterol and lipogenesis pathways. During infection, HCV activates host lipid metabolism through various molecular mechanisms that may ultimately contribute to the development of hepatic steatosis.

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The Immune System and Viral Hepatitis

Cited by 2 publications

References 70 publications

Beneficial effects of naringenin in liver diseases: Molecular mechanisms

Beneficial effects of naringenin in liver diseases: Molecular mechanisms

Особенности Обмена Липидов При HCV-инфекции

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