The Immune System—A Double-Edged Sword for Adenovirus-Based Therapies
Rebecca Wallace,
Carly M. Bliss,
Alan L. Parker
Abstract:Pathogenic adenovirus (Ad) infections are widespread but typically mild and transient, except in the immunocompromised. As vectors for gene therapy, vaccine, and oncology applications, Ad-based platforms offer advantages, including ease of genetic manipulation, scale of production, and well-established safety profiles, making them attractive tools for therapeutic development. However, the immune system often poses a significant challenge that must be overcome for adenovirus-based therapies to be truly efficaci… Show more
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