The immune status of patients with HIV infection, combined with chronic viral hepatitis C

Abstract

Characteristic for HIV changes are significant decrease in the number of T-helper / inducer (CD3+ CD4+), natural killer cells (CD-CD16+ CD56+) and the coefficient ratio of CD3+ CD4+ /CD3+ CD8+. An opposite pattern of change in the direction of increasing the content recorded in the cytotoxic T-lymphocytes (CD3+ CD8+), killer T lymphocytes (CD3+ CD16+ CD56+) and lymphocytes expressing activation antigens (CD3 + HLA-DR+; CD71+ CD8+ CD38+), including the CD95+ cells, inducing apoptosis. In patients with mixed infection is observed more pronounced degree of expression FH0-alpha and IFNΥon lymphocytes, induced by HIV. Of particular importance is the decrease in serum cytotoxin Th-cells-IFN-ΥHIV infection was most pronounced in patients with mixed pathology. INSTALLATIONS pronounced increase of serum cytokine TNF-α in patients with concomitant pathology than with monoinfection. Similar orientation changes of Th2 cytokine-cells -interleukin-4 is observed in HIV infections, especially when it is combined with current HCV. Revealed significant B lymphopenia and polyclonal activation of CD19+ cells, which was characterized by increased content of IgA, IgM, IgG, IgE, more pronounced when the mixed pathology. Prognostic criteria more rapid progression of HIV infection in patients with HCV are increasing the number of cytotoxic T lymphocytes expressing CD38 (CD8+ CD38+), receptor Fas -apoptoza CD95+, elevation of serum cytokines (TNF-α, IL-4) and reduced IFN levels -Υ.