The immune response to Plasmodium falciparum malaria

Immunomodulatory effects of recombinant BCG expressing MSP-1C ofPlasmodium falciparumon LPS- or LPS+IFN-γ-stimulated J774A.1 cells

“…Although TNF-α and IL-1β are associated with severe malaria and cerebral malaria in children, 67,68 they are also important for parasite killing during malaria infection. [12][13][14][15][16][69][70][71][72] Similar to other results, the production of TNF-α and IL-1β by infected macrophages increased with LPS and LPS+IFN-γ. These results also consistent with several other studies showing that BCG stimulates the production of TNF-α and IL-1β by macrophages, [73][74][75] and the stimulation is enhanced in the presence of LPS 73 and further enhanced with the presence of LPS+IFN-γ.…”

A 24-bp duplication in exon 10 of human chitotriosidase gene from the sub-Saharan to the Mediterranean area: role of parasitic diseases and environmental conditions

“…This result suggested that Chit could have a role in the immune response and in the outcome of malaria infection. 17 Moreover, in chimpanzee, it has been demonstrated that IL-12 injection is associated with an enhanced Chit activity, 18 this finding is important since a recent study has shown that protective immunity in malaria is mediated by a cascade of events involving IL-12. 19,20 We cannot rule out the possibility that the elevated levels of IL-12 modulate the macrophage activity stimulating their microbicidal function through a pathway involving Chit activity.…”

Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in The Gambia

“…23 for a review). The chromosome 21q22.11 locus contains several genes coding for such molecules including IFNAR1, IFNAR2, IFNGR2 and IL10RB.…”