The immune response in iron-deficient children: Impaired cellular defense mechanisms with altered humoral components

Macdougall, Lorna G.; Anderson, Ronald; McNab, G.M.; Katz, J.

doi:10.1016/s0022-3476(75)80211-3

Cited by 188 publications

(69 citation statements)

References 39 publications

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“…Iron-deficient children have a decreased per centage of T lymphocytes that is corrected by 4-weeks of iron supplementation (32,38,39). A dimin ished production of macrophage inhibition factors by the lymphocytes of patients with iron deficiency anemia has been reported (40).…”

Section: Iron Deficiency and Infectionmentioning

confidence: 99%

Functional consequences of iron deficiency in human populations.

Scrimshaw

1984

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Section: Iron Deficiency and Infectionmentioning

confidence: 99%

Functional consequences of iron deficiency in human populations.

Scrimshaw

1984

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Leukocytes (neutrophils, in particular) appear to have a reduced capacity to ingest and neutralize microorganisms (Chandra, 1973;Macdougall et al 1975;Srikantia et al 1976), while mitogen-stimulated lymphocytes exhibit a decreased ability to replicate (Neckers & Cossman, 1983). Additionally, depressed T-cell responses have been widely documented, with the depression proportional to the severity of iron deficiency (Chandra, 1973;Srikantia et al, 1976, Bagchi et al, 1980Prema et al, 1982).…”

Section: Resistance To Infectionmentioning

confidence: 99%

“…Consequences of IDA are devastating: inhibited growth, impaired cognitive development, poor mental and motor performance, reduced work capacity, and an overall decreased quality of life (Macdougall et al, 1975;Newhouse et al, 1989;Preziosi et al, 1997;Soewondo et al, 1989;Walter et al, 1989;Zhu & Haas, 1997).…”

Section: Introductionmentioning

confidence: 99%

Iron Deficiency Anemia: A Public Health Problem of Global Proportions

Charles¹

2012

Public Health - Methodology, Environmental and Systems Issues

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“…19 ) .. Such n ut ritionc l defic ien cies, e specially prote in-ca l o rie mal nutr i ti on , c an b y themselvee lead to PKN mi c r ob i cid a l defecue , Second ly , s ome of t he pa t ien ts s tudi ed ha d concu r r e n t or r e cent i n f e c t ions ( 8,19 ). which c a n a ls o alter the fun ct i ons o f PMNs an d the i r met ab o lis m.…”

mentioning

confidence: 99%

Neutrophil Bactericidal Dysfunction Towards Oxidant Radical-Sensitive Microorganisms During Experimental Iron Deficiency

Moore

Humbert

1984

Pediatr Res

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[NTRODUCTION An ad eq uate supp ly of i ro n appear s essent i a l t o the op timal fu n c t i on of several ilUpor t an t c el I lines invo lved in t he hoa c ' 8 defense agains t infec tion . Converse ly, during iron d e f i c ienc y a nucce r o f c ellu lar imroone dysfun c tions h a v e be en demons t r a ted . p are i cul arl y i n r e gard t o pol ymor phon ucl ea r ne ut r o pbils .I n e igh t o f n ine stud i e s ( 1, 6, 7 ,8 , 9 . 1 9 ,28 ,31 ,33 > of c h ild r en with i r on defi cie n cy ne u t r o phil (PHN) mi crob i cidal activit y '1 88 r ep ortedl y red uc ed (Tabl e 1 ) . Nitroblue tetr a zoli um ( NBT) reduct i on by PHNs was found decreas ed in two s tu dies ( 6 . 8 ) and n orm al i n fo ur investigation s ( 9 , 12 , 19 . 33>-Neutroph il my el o peroxidase OtPO ) act ivity was n ormal in two report s (1 2, 33) and d ecr eased i n two others ( 1, 13) .. Hexose monoph oap ha t e s hun t a ct i v it y , tes t ed i n one s tu dy ( 3), was f ound to be d e fe c tive . j'heee ava ilabl e d at a , alt hou gh f ragment ed a nd inc omplet e , sugges t th e e xis ten c e o f a d e fec t in t h e b ac t e ricida l ox i d a ti ve mach i n e r y of eeutropb i Le , whi ch co u ld affect th e d ev e lopment of c lin ic a l infe ct i on s in some pati e nts wi t h iron de fi c i ency (fo r a'rec en t review of t be much d eb a t ed r e la tions hip b etween i n fec tions a nd iron balan ce . s ee r ef IS ).S t udies of PHN f unct i on i n 10 r eaa.in con t roversi a l for severa l r eaecn e , Fi rst. i n a t l e ast fi v e of t he ee studi es, th e n e u tr ophil dy sfun c tions shown were presen t i n associ a t ion vi th nu t r i tio na l d e f i cienc ies o t her than i r on ( 1 . 6 . 8. 9 . 19 ) .. Such n ut ritionc l defic ien cies, e specially prote in-ca l o rie mal nutr i ti on , c an b y themselvee lead to PKN mi c r ob i cid a l defecue , Second ly , s ome of t he pa t ien ts s tudi ed ha d concu r r e n t or r e cent i n f e c t ions ( 8,19 ). which c a n a ls o alter the fun ct i ons o f PMNs an d the i r met ab o lis m.The purpose of this res earc h i s to clarify t h e c ontribut i on of isolated nu t riti ona l iron d e f i ci en c y to neutroph il dys functions in experimental a n i mals, in tbe abse n ce of other nut riti onal deficien c ies and o f infect ions. Our specific cb j ec t.Ivee are to establ hb a proper anima l ecd e I for the d ev elo pmen t of pu r e iron d eficiency wit hou t at tenda n t malnu trit i on; to d etermi ne whether pure i ron d e fi cie nc y c aus es d ysfunc tion o f neut r oph il phagoc yt osi s a nd ba cte ri c ida l activit y ; t o d e eered ue f urth er whether s uch neutrop b i l .dy s fu n ct iolls . i f presen t . ar e as s oc i at ed v i th d e f e c ts o f th e two ma jor i r on -d e pe nde n t e oz y-.e s ( myeloperox i d ase a nd NAOPH-ox idase) ; an d t o detera i ne whe th e r c orrect i on of t h e iron defi cien c y v ould co rrec t th e pu tat i ve f unc tiona l and metaboli c n e ut r ophil defects . II . MATERIALS AND MEI1IODSe , Ani .. h aod s ...

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The immune response in iron-deficient children: Impaired cellular defense mechanisms with altered humoral components

Cited by 188 publications

References 39 publications

Functional consequences of iron deficiency in human populations.

Functional consequences of iron deficiency in human populations.

Iron Deficiency Anemia: A Public Health Problem of Global Proportions

Neutrophil Bactericidal Dysfunction Towards Oxidant Radical-Sensitive Microorganisms During Experimental Iron Deficiency

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