The immune response and fertility of koalas (Phascolarctos cinereus) immunised with porcine zonae pellucidae or recombinant brushtail possum ZP3 protein

Kitchener, Anne L.; Kay, D. J.; Walters, Bryan; Menkhorst, Peter; McCartney, Carmen A.; Buist, Janine A.; Mate, Karen E.; Rodger, John C.

doi:10.1016/j.jri.2009.07.001

Cited by 22 publications

(16 citation statements)

References 21 publications

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“…There are four major ZP glycoproteins, named ZP1, ZP2, ZP3 and ZP4, each with different functions in the oocyte-sperm binding process and with varying degrees of homology among mammalian species (e.g. Kitchener et al 2009;Gupta and Bhandari 2011). These differences are partly responsible for the variable results obtained when using a particular ZP vaccine on different species and have been exploited to make ZP-based vaccines more specific (Kitchener et al 2009;Levy 2011).…”

Section: Immunocontraceptive Vaccinesmentioning

confidence: 99%

“…These differences are partly responsible for the variable results obtained when using a particular ZP vaccine on different species and have been exploited to make ZP-based vaccines more specific (Kitchener et al 2009;Levy 2011). Porcine ZP (PZP) immunocontraceptive vaccines, derived from ZP isolated from pig ovaries, have been effective in many ungulate species, monkeys, seals, bears and marsupials, but not in rodents, cats, dogs and wild pigs (Eade et al 2009;Kitchener et al 2009;Kirkpatrick et al 2009Kirkpatrick et al , 2011 McLaughlin and Aitken 2011; Table 1). However, recently formulated recombinant PZP3 and PZP4 vaccines, delivered in three injectable doses, caused infertility in up to 89% mice, depending on the formulation type (Gupta et al 2013).…”

Section: Immunocontraceptive Vaccinesmentioning

confidence: 99%

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Fertility control to mitigate human–wildlife conflicts: a review

2014

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Abstract. As human populations grow, conflicts with wildlife increase. Concurrently, concerns about the welfare, safety and environmental impacts of conventional lethal methods of wildlife management restrict the options available for conflict mitigation. In parallel, there is increasing interest in using fertility control to manage wildlife. The present review aimed at analysing trends in research on fertility control for wildlife, illustrating developments in fertility-control technologies and delivery methods of fertility-control agents, summarising the conclusions of empirical and theoretical studies of fertility control applied at the population level and offering criteria to guide decisions regarding the suitability of fertility control to mitigate human-wildlife conflicts. The review highlighted a growing interest in fertility control for wildlife, underpinned by increasing numbers of scientific studies. Most current practical applications of fertility control for wild mammals use injectable single-dose immunocontraceptive vaccines mainly aimed at sterilising females, although many of these vaccines are not yet commercially available. One oral avian contraceptive, nicarbazin, is commercially available in some countries. Potential new methods of remote contraceptive delivery include bacterial ghosts, virus-like particles and genetically modified transmissible and non-transmissible organisms, although none of these have yet progressed to field testing. In parallel, new species-specific delivery systems have been developed. The results of population-level studies of fertility control indicated that this approach may increase survival and affect social and spatial behaviour of treated animals, although the effects are species-and context-specific. The present studies suggested that a substantial initial effort is generally required to reduce population growth if fertility control is the sole wildlife management method. However, several empirical and field studies have demonstrated that fertility control, particularly of isolated populations, can be successfully used to limit population growth and reduce human-wildlife conflicts. In parallel, there is growing recognition of the possible synergy between fertility control and disease vaccination to optimise the maintenance of herd immunity in the management of wildlife diseases. The review provides a decision tree that can be used to determine whether fertility control should be employed to resolve specific human-wildlife conflicts. These criteria encompass public consultation, considerations about animal welfare and feasibility, evaluation of population responses, costs and sustainability.

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Section: Immunocontraceptive Vaccinesmentioning

confidence: 99%

Section: Immunocontraceptive Vaccinesmentioning

confidence: 99%

Fertility control to mitigate human–wildlife conflicts: a review

2014

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“…), koalas ( Phascolarctos cinereus ) (Kitchener et al. ) and grey seals ( Halichoerus grypus ) (Brown et al. ).…”

Section: Immunosterilization/immunocontraceptionmentioning

confidence: 99%

“…The good results and low side effects in the use of porcine ZP3 for contraception were achieved in feral horses (Equus caballus) (Kirkpatrick et al 1990 (Kitchener et al 2009) and grey seals (Halichoerus grypus) (Brown et al 1997). Vaccinated ZP feral horses and white-tailed deer had no health problems, except oophoritis Turner 2002, 2003;Curtis et al 2007).…”

Section: Zona Pellucida Immunizationmentioning

confidence: 99%

Suppression of Fertility in Adult Dogs

Maenhoudt

Santos

Fontbonne

2014

Reprod Domestic Animals

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Contents Unfortunately, the overpopulation of dogs is still a problem in the majority of countries and even though surgical methods of sterilization, the most traditional and commonly used technique, have been intensively performed, the impact on the dog population is negligible. The neutering of companion animals as ovariohysterectomy (spaying) or orchidectomy (castration) has its limitations because of the cost, the need of a surgical environment and the risk of surgical and/or anaesthetical complications (ACCD 2009). In fact, surgical castration has been banished in some northern European countries and has limited acceptance in other countries. In a survey performed in Sao Paulo, Brazil, 56.5% of the owners of adopted shelter dogs were against the surgical procedure for different reasons (Soto et al. 2005). Currently, the options for contraception, defined as suppression of fertility are based on hormonal treatment. The treatments can be divided into analogues of gonadotropin releasing hormone (GnRH), progestins and androgens. Other possibilities of contraception are via the immunological system with vaccinations against GnRH, the luteinizing hormone (LH) receptor and the zona pellucida proteins. Finally, there is also the intra‐epididymal or intratesticular injection of sclerosing substances in dogs. Mechanical devices to disrupt fertility are not used anymore due to the side effects. Suppression of fertility in adult dogs will be reviewed in order of use and possible impact on the dog population.

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“…115 In Australia and New Zealand, the potential of recombinant brushtail possum (Trichosurus vulpecula) ZP3 protein to control the fertility of Koalas (Phascolarctos cinereus) and Eastern Grey Kangaroos (Macropus giganteus) has also been investigated. 117,118 Inhibition of fertility by DNA vaccine encoding ZP proteins Immunization of mice with DNA vaccines encoding either bonnet monkey ZP4 or canine ZP3 led to the generation of antibodies reactive with respective native ZP matrix. 119,120 Antibodies generated by DNA vaccine encoding bonnet monkey ZP4 also led to inhibition of the binding of human sperm to human ZP.…”

Section: Potential Of Recombinant Zp Proteins For Inhibiting Fertilitymentioning

confidence: 99%