The Immune-Related Gene ELF3 is a Novel Biomarker for the Prognosis of Ovarian Cancer

Abstract

Background Ovarian cancer (OC) is a fatal gynaecological malignancy. The study aimed to conduct a comprehensive study to determine the role of ELF3 in OC through bioinformatic analysis. Methods Kruskal–Wallis test, Wilcoxon sign-rank test, and logistic regression were used to evaluate the relationship between clinical characteristics and ELF3 expression. Kaplan–Meier method and Cox regression analysis were used to evaluate the prognostic factors. Gene set enrichment analysis (GSEA) and immuno-infiltration analysis were used to evaluate the significant involvement of ELF3 in function. Results High ELF3 expression in OC was associated with age (P< 0.001). High ELF3 expression predicted a poorer overall survival (OS) (HR: 1.37; 95% CI: 1.05–1.78; P=0.019) and disease specific survival (DSS) (HR: 1.43; 95% CI: 1.08–1.89; P=0.013). And ELF3 expression (HR: 1.779; 95% CI: 1.281–2.472; P<0.001) was independently correlated with OS in OC patients. GSEA demonstrated that pathways including GPCR-ligand binding, neuronal system, signaling by WNT, translation, neuroactive ligand-receptor interaction, and TCF dependent signaling in response to WNT were differentially enriched in ELF3 low expression phenotype. Immune infiltration analysis showed that ELF3 expression was correlated with immune infiltrates. Conclusion ELF3 expression in OC patients was significantly associated with poor survival and immune infiltration and a promising prognostic biomarker in OC.

LncRNA ADAMTS9-AS2 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lung Adenocarcinoma

“…International Journal of General Medicine 2021:14 8544 references. 17,18 Molecule: ADAMTS9-AS2. Clinical variables: N stage, gender, number_pack_years_smoked, and smoker.…”

High STK40 Expression as an Independent Prognostic Biomarker and Correlated with Immune Infiltrates in Low-Grade Gliomas

“…The analysis method is described in the previous literature. 17,18 Prognosis type: OS. Included variables: clinical characteristics and STK40.…”

“…The analysis method is described in the previous literatures. 18,19 Molecule: STK40. Data: RNAseq data in level 3 HTSeq-Counts format from the TCGA LGG project.…”

“…The analysis method is described in the previous literatures. 18,20,21 Immune Infiltration Analysis by ssGSEA The analysis method is described in the previous literature. 18,22,23 Molecule: STK40.…”

“…18,20,21 Immune Infiltration Analysis by ssGSEA The analysis method is described in the previous literature. 18,22,23 Molecule: STK40. Data: RNAseq data and clinical data in level 3 HTSeq-FPKM format from the TCGA LGG project.…”