The Immune Basis of Allergic Lung Disease

Burleson, Stefanie C.M.; Fick, Robert B.; Mannie, Mark D.; Olmstead, Stephen; Scott, Michael R. Van

doi:10.1016/b978-0-12-404577-4.00035-7

Cited by 6 publications

(5 citation statements)

References 269 publications

(385 reference statements)

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“…IL-6 has been recognized as a cytokine involved in inflammation, but also as a cytokine with regenerative and anti-inflammatory properties [20]. However, interleukin-10 (IL-10) suppresses the activity of monocytes and macrophages activity, and downregulates secretion of selected cytokines, such as TNF-α and IL-6, which are involved in inflammatory processes [21]. IL-10 is secreted to limit the release of TNF-α and IL-6 and to decrease inflammatory responses [22].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of bioactivity of fucoidan from laminaria with in vitro human cell cultures (THP-1)

Stefaniak‐Vidarsson¹,

Guðjónsdóttir²,

Marteinsdóttir³

et al. 2017

FFHD

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Background: Seaweeds represent one of the few remaining food sources available globally which are not being fully utilized or even over utilized. Kelps (Laminaria spp.) are one of the numerous species of brown seaweeds, a popular marine vegetable, which has been used as a source of iodine and minerals for centuries. Kelps contain anionic polysaccharides called fucoidans heteroglycans with L – fucose units. Their monosaccharide composition, physicochemical and bioactive properties vary between seaweed species. The objective of this work was to evaluate the bioactive properties of laminaria fucoidan (L. digitata and L. hyperborea) toward THP–1 macrophages, a human macrophage like cell line, and investigate its potential antioxidant and immunomodulatory characteristics.Methods: THP-1 macrophages were incubated with five fucoidan concentrations. The Oxygen Radical Absorbance Capacity (ORAC) assay was determined for cell lysates and for the fucoidan extract, in addition to Total Polyphenol Content (TPC). Cytotoxicity of fucoidan was assessed by light microscopy, followed by XTT proliferation assay. Enzyme–linked immunosorbant assays (ELISA) were performed to determine concentrations of the secreted tumor necrosis factor α (TNF-α), interleukin 6 (IL–6), and interleukin 10 (IL–10). Results: Fucoidan did not affect macrophage ability to scavenge oxygen radicals (ORAC) confirming its antioxidant properties toward activated macrophages. The laminaria fucoidan extract at 100 µg/ml concentration lowered macrophage viability. Lower concentrations of laminaria fucoidan did not have impact on cell viability. Very low concentration of fucoidan at 0.1 µg/ml triggered secretion of TNF-α. However, IL–6 and interleukin IL–10 were expressed when concentration of applied fucoidan was 10 µg/ml indicating bioactivity of laminaria fucoidan through immunomodulatory actions.Conclusions: The study demonstrated how laminaria fucoidan may have bioactive properties towards THP–1 macrophages. Changes in cytokine secretion between pro–inflammatory (TNF–α, and IL–6) and anti–inflammatory (IL–10) cytokines confirmed bioactivity of the laminaria fucoidan extracts.Keywords: Seaweeds, Kelps, Laminaria, fucoidan, bioactivity, macrophages

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Section: Introductionmentioning

confidence: 99%

Evaluation of bioactivity of fucoidan from laminaria with in vitro human cell cultures (THP-1)

Stefaniak‐Vidarsson¹,

Guðjónsdóttir²,

Marteinsdóttir³

et al. 2017

FFHD

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“…Its primary function is to facilitate immune responses and dampen inflammation, also by downregulating pro-inflammatory cytokine secretion (e.g., TNF-α, IL-6, etc.) [52]. As a result, it may be a factor that influences anti-tumor and/or mucosal immune responses.…”

Section: Discussionmentioning

confidence: 99%

The effects of Rhus coriaria L. (sumac) and Cinnamomum zeylanicum L. bark on serum cytokine levels in rat mammary carcinogenesis

Sadlonova,

Mazurakova,

Koklesova

et al. 2023

neo

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The purpose of this study was to assess the potential effects of Rhus coriaria L. (sumac) and of Cinnamomum zeylanicum L. bark on the selected serum cytokines as possible serum tumor markers -interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-α (TNF-α) in the rat model of mammary carcinogenesis. R. coriaria and C. zeylanicum bark were used as the chemopreventive-therapeutic agents taken by rats in the powder form in the diet at two different concentrations during the entire period of two experiments carried out separately: lower concentration 1 g/kg -0.1% and higher concentration 10 g/kg -1%. The serum levels of cytokines of IL-6, IL-10, and TNF-α were determined using an enzymelinked immunosorbent assay. In the first experiment treated with R. coriaria, a significant decrease in serum levels of IL-6 and TNF-α was present at higher concentrations compared to the chemoprevention-free control group. R. coriaria at lower concentrations non-significantly reduced the serum levels of IL-6 and TNF-α when compared to controls. A significant decrease in serum levels of TNF-α was present at higher concentrations compared to lower concentrations. The significant effect of R. coriaria on the serum levels of IL-10 was not observed. In the second experiment treated with C. zeylanicum bark, a significant decrease in serum levels of IL-6 was observed in lower and higher concentrations compared to the chemoprevention-free control group. C. zeylanicum bark non-significantly reduced the serum levels of TNF-α and had no effect on the serum levels of IL-10. In conclusion, R. coriaria and C. zeylanicum bark demonstrated significant anti-inflammatory effects by analyzing the selected serum cytokine levels in the rat breast carcinoma model. Observed anti-inflammatory effects of both plant-natural substances were associated with their anticancer activities in rats.

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“…IL-12, produced primarily by monocytes and macrophages, stimulates the growth of NK cells (at least in part) and Th1 cells through binding to its receptor on these cells (50). The effect elicited by IL-18 resembles the effect of IL-12, possibly because they synergize (51).…”

Section: Il-12 and Il-18mentioning

confidence: 99%

Regulation of mRNA stability contributes to the function of innate lymphoid cells in various diseases

et al. 2023

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Innate lymphoid cells (ILCs) are important subsets of innate immune cells that regulate mucosal immunity. ILCs include natural killer cells, innate lymphoid cells-1 (ILC1s), ILC2s, and ILC3s, which have extremely important roles in the immune system. In this review, we summarize the regulation of mRNA stability mediated through various factors in ILCs (e.g., cytokines, RNA-binding proteins, non-coding RNAs) and their roles in mediating functions in different ILC subsets. In addition, we discuss potential therapeutic targets for diseases such as chronic obstructive pulmonary disease, cancer, and pulmonary fibrosis by regulation of mRNA stability in ILCs, which may provide novel directions for future clinical research.

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The Immune Basis of Allergic Lung Disease

Cited by 6 publications

References 269 publications

Evaluation of bioactivity of fucoidan from laminaria with in vitro human cell cultures (THP-1)

Evaluation of bioactivity of fucoidan from laminaria with in vitro human cell cultures (THP-1)

The effects of Rhus coriaria L. (sumac) and Cinnamomum zeylanicum L. bark on serum cytokine levels in rat mammary carcinogenesis

Regulation of mRNA stability contributes to the function of innate lymphoid cells in various diseases

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