The Immediate Haemodynamic and Electrophysiological Response to Prenalterol during Fixed Rate Pacing in Patients with Chronic Ischaemic Heart Disease

Abstract

The immediate haemodynamic and electrophysiologic effects of intravenous prenalterol 2.5–75μg/kg in patients with coronary heart disease without clinical heart failure were investigated during fixed rate atrial pacing. Right ventricular peak dP/dt increased pronounced and serum concentration dependent after prenalterol concomitant with an increase in stroke volume and a moderate decrease in peripheral vascular resistance. The effects on haemodynamics after prenalterol were thus serum concentration dependent but with marked interindividual variation. AV nodal conduction velocity increased significantly. It is concluded that prenalterol possess pronounced inotropic properties. The haemodynamic response to prenalterol intravenously is to a lesser degree dependent on the chronotropic effects of the drug and it is often unpredictable.