The Immediate Effects of Intermittent Theta Burst Stimulation of the Cerebellar Vermis on Cerebral Cortical Excitability During a Balance Task in Healthy Individuals: A Pilot Study

Tan, Huixin; Wei, Qian; Chen, Yi; Xie, Yun-Juan; Guo, Qifan; He, Lin; Gao, Qiang

doi:10.3389/fnhum.2021.748241

Cited by 9 publications

(13 citation statements)

References 59 publications

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“…In the block-design balance tasks measured by fNIRS, a major activation trend (P > 0.05 FDR-corrected) was observed on ipsilateral DLPFC, PM-SMC, and contralateral PMC after CB-SMA iTBS protocol in the EC balance block-designed fNIRS task. The activation of bilateral SMA after single-CB iTBS has been observed when healthy people perform balance tasks ( 22 ). Meanwhile, the activation of the DLPFC may represent a compensation effect for demanding balance tasks when patients have sensorimotor deficits ( 24 ), as well as a representation of better neural efficiency ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

“…1, 4), Broca's network (Ch. 15,21,22), Wernicke network (Ch. 2, 3, 5, 7, 8, 10, 11), sensory network (Ch.…”

Section: Whole-brain Fc Matrixmentioning

confidence: 99%

“…Meanwhile, fNIRS has been proven to be sensitive to the changes induced by online and offline TMS protocols (19)(20)(21), which makes it an effective way to investigate the neural modulation influence caused by TMS. Previous studies showed that activation changes in the bilateral SMA can be recorded through fNIRS when healthy individuals perform balance tasks after cerebellumsingle (CB-single) intermittent TBS (iTBS) (22). The activation of the SMA and dorsolateral prefrontal cortex (DLPFC) is also negatively correlated with the balance function in populations that are healthy or with neurological diseases when balance tasks are highly demanding (23)(24)(25)(26).…”

Section: Introductionmentioning

confidence: 99%

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Cerebellum–Cerebrum paired target magnetic stimulation on balance function and brain network of patients with stroke: A functional near-infrared spectroscopy pilot study

Xia

Tang²,

Hu³

et al. 2022

Front. Neurol.

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Transcranial magnetic stimulation (TMS) modulation over the cerebellum, primary motor cortex, and supplementary motor cortex individually can improve the balance function of patients with stroke. However, whether their combination could have a better balance modulation effect is uncertain. Therefore, we hypothesized that performing TMS over a combination of these targets can regulate the balance function of patients with stroke. We compared the effects of one-session TMS on eye-open and eye-closed balance conditions in patients with stroke, using different target pairs of unilateral cerebellar (CB-single), cerebellar–primary motor cortex (CB-M1), and cerebellar–supplementary motor area (CB-SMA) targets. A total of 31 patients with stroke were enrolled and randomly divided into three groups to receive single sessions of intermittent theta burst stimulation each. Functional near-infrared spectrum data on resting and standing task states (eye-open and eye-closed) and center of pressure parameters (eye-open and eye-closed) were collected before and after the intervention. Compared with the results in the CB-single group, five intergroup differences in the changes in the center of pressure parameters in the CB-M1 group and two significant differences in the CB-SMA group were observed after one session of intermittent theta burst stimulation. In the CB-SMA group, 12 out of the 14 parameters improved significantly in the EC condition after the intervention. Meanwhile, the functional near-infrared spectrum results showed that the CB-SMA group exhibited a significant inhibitory pattern in the resting-state functional connectivity, which was not observed in the other two groups. In conclusion, we believe that paired targeting of the CB-SMA can reshape the brain network and improve the balance function of patients with stroke.

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Section: Discussionmentioning

confidence: 99%

“…1, 4), Broca's network (Ch. 15,21,22), Wernicke network (Ch. 2, 3, 5, 7, 8, 10, 11), sensory network (Ch.…”

Section: Whole-brain Fc Matrixmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cerebellum–Cerebrum paired target magnetic stimulation on balance function and brain network of patients with stroke: A functional near-infrared spectroscopy pilot study

Xia

Tang²,

Hu³

et al. 2022

Front. Neurol.

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“…Our preliminary pilot study found that cerebellar vermis iTBS contributed to increasing the excitability of the bilateral supplementary motor areas (SMAs) during balance tasks in healthy adults. 23 …”

Section: Introductionmentioning

confidence: 99%

Effectiveness of cerebellar vermis intermittent theta-burst stimulation in improving trunk control and balance function for patients with subacute stroke: a randomised controlled trial protocol

et al. 2023

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IntroductionBalance impairments frequently occur after stroke. Achieving effective core trunk stability is the key to improving balance ability. However, there is still a lack of advanced well-defined rehabilitation protocols for balance improvement in patients with stroke. Intermittent theta-burst stimulation (iTBS) is a non-invasive brain activity modulation strategy that can produce long-term potentiation. The cerebellar vermis is a fundamental structure involved in balance and motor control. However, no study has demonstrated the therapeutic effect and potential mechanism of cerebellar vermis iTBS on balance after stroke.Methods and analysisThis study will be a prospective single-centre double-blind randomised controlled clinical trial with a 3-week intervention and 3-week follow-up. Eligible participants will be randomly allocated to the experimental group or the control group in a 1:1 ratio. After routine conventional physical therapy, patients in the experimental group will receive cerebellar vermis iTBS, whereas patients in the control group will receive sham stimulation. The overall intervention period will be 5 days a week for 3 consecutive weeks. The outcomes will be measured at baseline (T0), 3 weeks postintervention (T1) and at the 3-week follow-up (T2). The primary outcomes are Berg Balance Scale and Trunk Impairment Scale scores. The secondary outcomes are balance test scores via the Balance Master system, muscle activation of the trunk and lower limbs via the surface electromyography recordings, cerebral cortex oxygen concentrations measured via the resting-state functional near-infrared spectroscopy, Fugl-Meyer Assessment of Lower Extremity and Barthel index scores.Ethics and disseminationThis study was approved by the West China Hospital Clinical Trials and Biomedical Ethics Committee of Sichuan University. All participants will sign the informed consent form voluntarily. The results of this study will be published in peer-reviewed journals and disseminated at academic conferences.Trial registration numberChiCTR2200065369.

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“…During the whole stepping process, proper engagement of the cortical cortex is also crucial to the balance equilibrium. The regions of the prefrontal cortex (PFC), pre-motor cortex (PMC), and primary motor cortex (M1) are all believed to participate in the regulation of balance control [ 14 ]. The reduced connectivity between cortical regions in older adults is accompanied by a worse performance of balance scales [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Age-Related Differences in Stepping Reactions to a Balance Perturbation: A Functional Near-Infrared Spectroscopy and Surface Electromyography Study

Zhuang¹,

Zhu

Sui

et al. 2022

Brain Sciences

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We sought to investigate age-related differences in stepping reactions to a sudden balance perturbation, focusing on muscle activity and cortical activation. A total of 18 older healthy adults (older group, OG) and 16 young healthy adults (young group, YG) were recruited into this study. A cable-pull instrument was used to induce a forward perturbation at the waist level among participants, who were required to take the right step to maintain their postural balance. The seven right lower-limb muscle activities during periods of compensatory postural adjustments (CPAs) were recorded by surface electromyography. At the same time, the signals of channels located in the prefrontal, temporal and parietal lobes were recorded by functional near-infrared spectroscopy (fNIRS) during the whole process. Integral electromyograms of the right peroneus muscle, gluteus medius, and lateral gastrocnemius muscles showed greater activity for the OG in the CPA periods. Two channels belonging to the right pre-frontal (PFC) and pre-motor cortex (PMC) revealed lower activation in the OG compared with the YG. These findings can help us to better understand the differences at the peripheral and central levels and may provide some suggestions for future neuromodulation techniques and other clinical treatments.

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The Immediate Effects of Intermittent Theta Burst Stimulation of the Cerebellar Vermis on Cerebral Cortical Excitability During a Balance Task in Healthy Individuals: A Pilot Study

Cited by 9 publications

References 59 publications

Cerebellum–Cerebrum paired target magnetic stimulation on balance function and brain network of patients with stroke: A functional near-infrared spectroscopy pilot study

Cerebellum–Cerebrum paired target magnetic stimulation on balance function and brain network of patients with stroke: A functional near-infrared spectroscopy pilot study

Effectiveness of cerebellar vermis intermittent theta-burst stimulation in improving trunk control and balance function for patients with subacute stroke: a randomised controlled trial protocol

Age-Related Differences in Stepping Reactions to a Balance Perturbation: A Functional Near-Infrared Spectroscopy and Surface Electromyography Study

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