The Immediate Effect of Shakuyaku-kanzo-to, Traditional Japanese Herbal Medicine, for Muscular Cramps during Maintenance Hemodialysis

Hyodo, Toru; Taira, Takayasu; Kumakura, Miyuki; Yamamoto, Sumiko; Yoshida, Kazunari; Uchida, Τοyoaki; Sakai, Tadasu; Endo, Tadao; Baba, Shirō; Hatta, Hideo

doi:10.1159/000049057

Cited by 30 publications

(28 citation statements)

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“…We reported for the first time the brief letter about the effect of Shakuyaku-kanzo-to for muscle cramp of HD patients in Nephron in 2002 [11]. We report precisely the effect of this herbal medicine in this paper.…”

Section: Discussionmentioning

confidence: 61%

Immediate Effect of Shakuyaku-kanzo-to on Muscle Cramp in Hemodialysis Patients

Hyodo¹,

Taira²,

Takemura³

et al. 2006

Nephron Clin Pract

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We administered 2.5 g of Shakuyaku-kanzo-to granule to 61 patients who had muscle cramp during hemodialysis (HD) sessions and examined its immediate effects. We selected 10 patients who wanted to take the drug at home, out of cases, for whom the drug was effective on the study described above and had them take the drug in the same way at the beginning of muscle cramp at home examined the effects. In the study during HD sessions, muscle cramp and its associated pain disappeared in 5.3 ± 3.9 min on average in 54 out of 61 cases. In the study of patients who took the drug at home, muscle cramp disappeared within 10 min in all cases. Shakuyaku-kanzo-to is thought to be very useful for muscle cramp during HD sessions of hemodialized patients because it has immediate effects by its oral administration on the occasion of cramp. With regard to the muscle cramp, which appears at home after HD sessions, the patients can cope with it by taking the drug by themselves. This is an epoch-making therapy, for it was impossible to cope with muscle cramp except in hospitals because the therapy of muscle cramp was limited to intravenous infusion of hypertonic solutions of dextrose, mannitol, and saline during HD sessions.

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Section: Discussionmentioning

confidence: 61%

Immediate Effect of Shakuyaku-kanzo-to on Muscle Cramp in Hemodialysis Patients

Hyodo¹,

Taira²,

Takemura³

et al. 2006

Nephron Clin Pract

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“…In the treatment of muscle cramps, central or peripheral muscle relaxants are commonly used; however, their therapeutic effects are not always sufficient, and these agents cause side effects such as hepatopathy, weakness, and thirst. Shakuyakukanzoto markedly improves muscle cramps and pain without side effects (4,5); therefore, this Kampo medicine may be clinically useful. In contrast to these observations, it has been reported that shakuyakukanzoto does not show any antinociceptive activitiy in response to noxious stimuli in normal experimental animals (6).…”

Section: Introductionmentioning

confidence: 98%

Antinociceptive Effect of Shakuyakukanzoto, a Kampo Medicine, in Diabetic Mice

et al. 2005

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Abstract. In this study, the antinociceptive effect of shakuyakukanzoto was investigated using streptozotocin-induced diabetic mice to certify its analgesic effect on diabetic patients. Shakuyakukanzoto (0.5 and 1.0 g / kg, p.o.) significantly increased the nociceptive threshold in diabetic mice. The antinociceptive activity of shakuyakukanzoto in diabetic mice was not antagonized by β-funaltrexamine, naltrindole, or nor-binaltorphimine. The increased antinociceptive activity of (1.0 g / kg, p.o.) in diabetic mice was abolished by yohimbine (15 µg, i.t.), but not by (1 µg, i.t.), methysergide (15 µg, i.t.), or MDL-72222 (15 µg, i.t.). In shakuyakukanzoto diabetic mice treated with 6-hydroxydopamine (20 µg, i.t.) chemically lesioned noradrenergic pathways, shakuyakukanzoto (1.0 g / kg, p.o.) failed to exhibit an antinociceptive effect. Furthermore, the antinociceptive activity induced by norepinephrine (0.06 -2 µg, i.t.) was markedly more potent in diabetic mice than in non-diabetic mice at the same dose. These results suggest that the antinociceptive effect of shakuyakukanzoto in diabetic mice is not mediated by the opioid systems and that this effect appears via selective activation of the spinal descending inhibitory α 2 -adrenergic systems without activating the serotonergic systems. The spinal α 2 -adrenoceptor-mediated analgesic mechanism was enhanced in diabetic mice, suggesting that shakuyakukanzoto exhibits its effect by activating the descending noradrenergic neurons.

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“…The main components of Shakuyaku and Kanzo are paeoniflorin and glycyrrhizic acid, respectively. It is widely used to relieve abdominal pain [8] and muscular cramps [9,10]. In this case, we administered SKT for the treatment of muscular cramp; however, it also relieved other symptoms beyond our expectation.…”

Section: Discussionmentioning

confidence: 91%

Successful use of Shakuyaku-kanzo-to, a traditional herbal medicine, for intractable symptoms of thoracic outlet syndrome: a case report

Kubota

Miyata

2005

J Anesth

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Shakuyaku-kanzo-to (SKT) is a traditional herbal medicine that is widely used for muscular cramp and abdominal pain. We administered SKT for a patient with thoracic outlet syndrome (TOS) complaining of several resting symptoms. A 28-year-old female patient complained of intractable pain in the left arm, shoulder, and back and weakness, numbness, and muscular cramp in the left arm. She was diagnosed as TOS by digital subtraction angiography. Two days after the start of administration of SKT, her severe pain was markedly improved. Although numbness of the left arm was not improved, her overall pain score was reduced by 2 on the 7th day after the start of SKT. SKT has several pharmacological effects including analgesic and antiinflammatory effects, vasodilation, and muscle relaxation. Thus, our report suggests that SKT could be a first-line agent for the conservative treatment of TOS.

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The Immediate Effect of Shakuyaku-kanzo-to, Traditional Japanese Herbal Medicine, for Muscular Cramps during Maintenance Hemodialysis

Cited by 30 publications

References 0 publications

Immediate Effect of Shakuyaku-kanzo-to on Muscle Cramp in Hemodialysis Patients

Immediate Effect of Shakuyaku-kanzo-to on Muscle Cramp in Hemodialysis Patients

Antinociceptive Effect of Shakuyakukanzoto, a Kampo Medicine, in Diabetic Mice

Successful use of Shakuyaku-kanzo-to, a traditional herbal medicine, for intractable symptoms of thoracic outlet syndrome: a case report

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