The imbalanced profile and clinical significance of T helper associated cytokines in bone marrow microenvironment of the patients with acute myeloid leukemia

Sun, Yuanxin; Kong, Hai-li; Liu, Chuanfang; Yu, Shuang; Tian, Tian; Ma, Daoxin; Ji, Chunyan

doi:10.1016/j.humimm.2013.11.014

Cited by 30 publications

(20 citation statements)

References 43 publications

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“…As an immunosuppressive cytokine, the predominant mechanism of suppression associated with the activity of IL‐35 is its ability to inhibit T cell differentiation and effector functions. IL‐35 plays a critical role in a variety of diseases, such as inflammatory bowel disease, T cell‐dependent colitis, central nervous system demyelination, smoking‐related lung inflammation, autoimmune diabetes, coronary artery diseases, autoimmune encephalomyelitis, human prostate tumor, atherosclerosis, pregnancy, arthritis, coronavirus‐induced encephalomyelitis, colorectal cancer, asthma, multiple sclerosis, pancreatic ductal adenocarcinoma, pancreas cancer, leukemia and systemic lupus erythematous …”

Section: Potential Role Of Il‐35 In Hbv Infectionmentioning

confidence: 99%

IL‐35: A potential therapeutic target for controlling hepatitis B virus infection

Xiang

Xie

2015

J of Digest Diseases

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Interleukin (IL)-35, a recently identified cytokine of the IL-12 family, is a potent immunosuppressive cytokine secreted by regulatory T (Treg) cells and the newly reported regulatory B (Breg) cells. IL-35 functions as a crucial immunosuppressive factor in immune-mediated diseases, and the predominant mechanism of suppression is its ability to suppress T cell proliferation and effector functions. The pathogenic processes of the non-cytopathic hepatitis B virus (HBV) infection-related liver diseases are immune-mediated, including liver damage and viral control. It has been found that IL-35 is detectable in peripheral CD4(+) T cells in chronic HBV-infected patients, whereas it is undetectable in healthy individuals. There is growing evidence that cytokine-mediated immune responses play a pivotal role in determining the clinical outcome during HBV infection. It is particularly important to investigate the effects of IL-35 in the immunopathogenesis of chronic HBV infection. In this study, the recent understanding of this issue is discussed.

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Section: Potential Role Of Il‐35 In Hbv Infectionmentioning

confidence: 99%

IL‐35: A potential therapeutic target for controlling hepatitis B virus infection

Xiang

Xie

2015

J of Digest Diseases

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“…CCR7 is one of the most important chemokine receptors for adaptive immune cell migration. Additionally, CCR7 also mediates the expression of signaling molecules, such as Th1 and Th2, that can affect the homeostasis, activation and polarization of T cells [37]. Interestingly, the KEGG analysis found that Th1, 2, 17 cell differentiation is one of the most significantly affected phased in AML-M4, It has been reported that the dysregulation of Th subset cytokines contribute to the pathogenesis of AML, while accumulating evidence also indicates that many diseases, including hematological malignancies, are involved the imbalance ratio of Th1/Th2.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Gene Expression Analysis Reveals Factors that Influence the Progression, Occurrence and Development of AML-M4

Zhang

et al. 2019

Preprint

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Background Acute myelomonocytic leukemia (M4), a special type of acute myeloid leukemia (AML), is a clonal malignant disease with poor prognosis and a low overall survival rate. Here, we aim to explore the molecular mechanism of AML-M4 development and progression using integrative bioinformatic analysis. Methods We used an integrative method to identify potential driven genes in AML-M4. We firstly identify DEGs using limma packages and annotated them by GO and KEGG. To avoid individual bias, GSEA was adopted to certify the results. Furthermore, we constructed the PPI network using WGCNA which was superimposed onto STRING database. We also assessed the correlation and mutation among hub genes to deeply explore the biological mechanism in AML-M4. Finally, we confirmed our results by experiments. Results The results show that FLT3, WT1 and TP53, which are involved in transcriptional misregulation were upregulated, while PPBP and CCR7, which regulate cytokine-cytokine receptor interaction, as well as CD24, which acts as a protein marker of AML, were downregulated. 12 hub genes were found through the TCGA an Oncomain analysis, and the results also show that FLT3, CCR7 and MMP-9 can be potential targets for the detection and treatment of AML-M4. Conclusion The overall aim of this study was to identify critical pathways and genes associated with AML-M4, and to also provide potential therapeutic targets and new research ideas for the treatment and early detection of AML-M4.

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“…It is important to investigate IL-35 expression in bone marrow of the patients with AML. Sun et al have reported that IL-35 expression in bone marrow plasma has no significant difference among ND, CR and control group, though marginally higher in AML-ND group than that in AML-CR patients [23]. In the previous study by Sun et al, IL-35 was measured by ELISA in BM plasma of AML patients including a group of ND patients and another group of CR patients.…”

Section: Suppression Of T-cell Proliferation (2) Conversion Of Naivementioning

confidence: 97%

Elevated IL-35 in bone marrow of the patients with acute myeloid leukemia

et al. 2015

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The imbalanced profile and clinical significance of T helper associated cytokines in bone marrow microenvironment of the patients with acute myeloid leukemia

Cited by 30 publications

References 43 publications

IL‐35: A potential therapeutic target for controlling hepatitis B virus infection

IL‐35: A potential therapeutic target for controlling hepatitis B virus infection

Comprehensive Gene Expression Analysis Reveals Factors that Influence the Progression, Occurrence and Development of AML-M4

Elevated IL-35 in bone marrow of the patients with acute myeloid leukemia

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