The imbalance of metal-containing proteins and free metal ions in the amniotic fluid during fetal growth

Pogorelova, T. N.; Линде, В А; Gunko, V. O.; Selyutina, S. N.

doi:10.18097/pbmc20166201069

Cited by 3 publications

(5 citation statements)

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“…A similar study investigated the levels of zinc, copper, iron and magnesium ions and certain binding proteins in the amniotic fluid under FGR conditions (116). FGR showed a decrease in the content of zinc, iron and magnesium ions and an increase in the content of copper in the amniotic fluid in the second and third trimesters of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Placental proteome in late‑onset of fetal growth restriction

et al. 2022

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Fetal growth restriction (FGR) occurs when the fetus does not reach its genetically programmed intrauterine potential for growth and affects ~5-10% of pregnancies. This condition is one of the leading causes of perinatal mortality and morbidity associated with obstetric and neonatal complications. Placental dysfunction in FGR causes an impairment in the transfer of nutrients and oxygen from the mother to the developing fetus. Maternal adaptations to placental insufficiency may also play a role in the pathophysiology of FGR. The present study aimed to compare the proteome of the placentas of 18 women with the physiological course of pregnancy and eutrophic fetus [estimated fetal weight (EFW) >10th percentile; control group] and 18 women with late FGR (EFW <10th percentile) diagnosed after 32 weeks of pregnancy, according to the Delphi consensus (study group). The U. Mann-Whitney test was used to compare two independent groups. The R. Spearman correlation coefficient significance test was used to assess the existence of a relationship between the analyzed measurable parameters. P<0.05 was considered to indicate a statistically significant difference. The tests showed the presence of 356 different proteins which were responsible for the regulation of gene transcription control, inhibiting the activity of proteolytic enzymes, regulation of trophoblast proliferation and angiogenesis and inflammatory response. In the FGR placental proteome, other detected proteins were mostly involved in response to oxidative stress, cellular oxidation and detoxication, apoptosis, hemostatic and catabolic processes, energy transduction protein interactions, cell proliferation, differentiation and intracellular signaling. The present study used chromatographic mass-spectrometry to compare the placental proteome profiles in pregnancies complicated by late-onset FGR and normal pregnancy. Comparative analysis of proteomes from normal and FGR placentas showed significant differences. Further research is needed to clarify maternal and fetal adaptations to FGR.

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Section: Discussionmentioning

confidence: 99%

Placental proteome in late‑onset of fetal growth restriction

et al. 2022

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“…Zn is essential for embryogenesis and neurogenesis. Deficiency in this element is associated with fetal growth retardation and neurodegenerative disorders (28,(49)(50)(51). It may also promote antimicrobial activity (15,17).…”

Section: Discussionmentioning

confidence: 99%

“…By contrast, high Cu concentrations may lead to diverse abnormalities. For example, high concentrations in maternal serum have been linked to pre-eclampsia ( 55 , 56 ), and elevated levels in the amniotic fluid have been associated with fetal growth retardation ( 28 ). When considering genetics, Cu is has been implicated in two major diseases, namely Wilson and Menkes diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Heavy metals in high concentrations have the ability to disrupt normal physiological processes. Copper (Cu), arsenic (As), Cd, nickel (Ni), chromium, mercury, manganese and Pb can lead to fetal growth retardation, pre-eclampsia, impaired cognitive development and even cancer (23)(24)(25)(26)(27)(28).…”

Section: Heavy Metal Ion Concentration In the Amniotic Fluid Of Preterm And Term Pregnancies From Two Cities With Different Industrial Oumentioning

confidence: 99%

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Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

et al. 2021

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The growth and development of the fetus is a complex phenomenon that can be influenced by several variables. High quantities of heavy metal ions in the amniotic fluid have been linked to poor health, especially in industrial, polluted and poor areas. The aim of the present study was to assess the differences in the concentration of these ions between preterm (weeks 15-37) and term pregnancies (starting at week 37). Another objective was to compare pregnancies from two cities with different industry levels. Two sample lots from two Romanian cities were analyzed. A total of 100 patients from Timisoara were compared with 60 from Petrosani, a heavy industry city in Romania. Demographic data were collected, and amniocentesis was performed on all women. Lead (Pb), copper (Cu), nickel (Ni), cadmium (Cd), arsenic (As), iron (Fe) and zinc (Zn) concentrations were assessed. Descriptive and analytical statistics were performed using the Mann-Whitney U test for non-parametric data and the Fisher's exact test for categorical data. In addition, categorical data was represented graphically. In the Timisoara cohort, the differences in heavy metal concentrations between preterm and term pregnancies were not statistically significant. In the Petrosani cohort, however, the concentrations of Zn (P=0.02606) and Cd (P=0.01512) were higher in preterm than in term pregnancies. When comparing the two cohorts as a whole, the concentration of Pb (P=0.04513), Cd (P=0.00002), As (P=0.03027) and Zn (P<0.00001) were higher in the patients from Petrosani than in those from Timisoara. Only Cu concentrations were higher in the Timisoara cohort (P<0.00001). The concentrations of Ni (P=0.78150) and Fe (P=0.44540) did not differ statistically. Thus, amniocentesis is an important diagnostic and exploratory tool in determining differences in the concentrations of elements such as heavy metal ions. Research over a longer period of time should be carried out to examine the relation between heavy metal ions concentration and possible postnatal health outcomes.

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“…Аналогичное действие может оказывать и изменение степени связывания с белка-ми, а именно с остатками ароматических аминокис-лот, ионов некоторых металлов, в частности цинка, который находится в составе домена «цинковые пальцы» в ряде регуляторных белков [14]. Показано, что при ПН имеет место перераспределение между свободным и связанным пулом цинка [15].…”

Section: результаты и обсуждениеunclassified