The imbalance of masticatory muscle activity affects the asymmetric growth of condylar cartilage and subchondral bone in rats

Miyazaki, M; Yonemitsu, Ikuo; Takei, Makoto; Kure-Hattori, Ikuko; Ono, Takashi

doi:10.1016/j.archoralbio.2015.11.020

Cited by 19 publications

(23 citation statements)

References 49 publications

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“…In turn, altered masticatory loading after masseter muscle resection in young rats leads to asymmetrical growth and reduced bone quality of the mandibular condyle. 5 Also, a change in the dietary regimen from hard to soft food in young adult mice results in a decrease in masseter mass 6 and alters the shape and size of the mandibular condyle [6][7][8] and the alveolar process. 6,7 Moreover, decreased loading using soft diet showed a detrimental effect on subchondral bone in the mandibular condyle of adult mice of both sexes, but the impairment on cell maturation in the condylar cartilage was exclusively found on female individuals.…”

Section: Backg Rou N Dmentioning

confidence: 99%

“…During post‐natal ontogeny, normal masticatory function is required for the proper development and homeostasis of the temporomandibular joint (TMJ) and the mandible. In turn, altered masticatory loading after masseter muscle resection in young rats leads to asymmetrical growth and reduced bone quality of the mandibular condyle . Also, a change in the dietary regimen from hard to soft food in young adult mice results in a decrease in masseter mass and alters the shape and size of the mandibular condyle and the alveolar process .…”

Section: Introductionmentioning

confidence: 99%

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Masseter muscle atrophy impairs bone quality of the mandibular condyle but not the alveolar process early after induction

Balanta‐Melo

Torres‐Quintana

Bemmann

et al. 2018

J of Oral Rehabilitation

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Summary Background Masseter muscle function influences mandibular bone homeostasis. As previously reported, bone resorption markers increased in the mouse mandibular condyle two days after masseter paralysis induced with botulinum toxin type A (BoNTA), followed by local bone loss. Objective This study aimed to evaluate the bone quality of both the mandibular condyle and alveolar process in the mandible of adult mice during the early stage of a BoNTA‐induced masseter muscle atrophy, using a combined 3D histomorphometrics and shape analysis approach. Methods Adult BALB/c mice were divided into an untreated control group and an experimental group; the latter received one single BoNTA injection in the right masseter (BoNTA‐right) and saline in the left masseter (Saline‐left). 3D bone microstructural changes in the mandibular condyle and alveolar process were determined with high‐resolution microtomography. Additionally, landmark‐based geometric morphometrics was implemented to assess external shape changes. Results After 2 weeks, masseter mass was significantly reduced (P‐value <0.001). When compared to Saline‐left and untreated condyles, BoNTA‐right condyles showed significant bone loss (P‐value <0.001) and shape changes. No significant bone loss was observed in the alveolar processes of any of the groups (P‐value >0.05). Conclusion Condyle bone quality deteriorates at an early stage of BoNTA‐induced masseter muscle atrophy, and before the alveolar process is affected. Since the observed bone microstructural changes resemble those in human temporomandibular joint degenerative disorders, the clinical safety of BoNTA intervention in the masticatory apparatus remains to be clarified.

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Section: Backg Rou N Dmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Masseter muscle atrophy impairs bone quality of the mandibular condyle but not the alveolar process early after induction

Balanta‐Melo

Torres‐Quintana

Bemmann

et al. 2018

J of Oral Rehabilitation

View full text Add to dashboard Cite

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“…In relevant studies, region‐specific bone mineral density was shaped by the neighbouring muscle system. In experiments on growing rats, condyle bone mineral density was lower in the masseter muscle‐resected site . Skull and mandibular bone mineral density values at BTX injection sites showed significant decreases .…”

Section: Discussionmentioning

confidence: 93%

“…In experiments on growing rats, condyle bone mineral density was lower in the masseter muscleresected site. 22 Skull and mandibular bone mineral density values at BTX injection sites showed significant decreases. 25 Hemi-mandible and zygoma bone volumes decreased in the masseter paralysis site.…”

Section: Bone Mineral Density Measurementsmentioning

confidence: 92%

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Effects of masticatory muscle function affected by BTX on maxillofacial bone growth through the sutural modification

Tsai

Wang

Chang

2019

Orthod Craniofacial Res

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Structured Abstract Objectives To evaluate the effect of botulinum toxin type A (BTX)‐induced masticatory muscle hypofunction on the maxillofacial suture bone growth of growing rats. Setting and Sample Population Department of Orthodontics at Taipei Medical University. Forty‐eight male 4‐week‐old Wistar rats were divided into four groups. The N group received injections of normal saline into each of the masseter and temporalis muscles. The M group received injections of normal saline into each of the temporalis muscle and injections of BTX into each of the masseter muscle. The T group received injections of normal saline into each of the masseter muscle and injections of BTX into each of the temporalis muscle. The MT group received injections of BTX into each of the masseter and temporalis muscles. Material & Methods Rats were sacrificed after 42 days of growth. Changes in body and muscle weight were measured. Anthropometric measurements of the maxillary arch, sutural bone mineral density and sutural bone deposition distances were recorded. Statistical comparisons were performed using analysis of variance. Results No significant change in body weight was found across groups. However, significant decreases were observed in muscle weight, anthropometric measurements, sutural bone mineral density and bone apposition distance in the BTX‐injected group. Conclusions Reduced masticatory muscle function in growing rats can affect maxillofacial suture bone growth.

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Micro-CT–Based Bone Microarchitecture Analysis of the Murine Skull

Tan

Labrinidis

Williams

et al. 2021

Methods in Molecular Biology

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X-ray micro-computed tomography (micro-CT) imaging has important applications in microarchitecture analysis of cortical and trabecular bone structure. While standardized protocols exist for micro-CT-based microarchitecture assessment of long bones, specific protocols need to be developed for different types of skull bones taking into account differences in embryogenesis, organization, development, and growth compared to the rest of the body. This chapter describes the general principles of bone microarchitecture analysis of murine craniofacial skeleton to accommodate for morphological variations in different regions of interest.

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The imbalance of masticatory muscle activity affects the asymmetric growth of condylar cartilage and subchondral bone in rats

Abstract: These findings imply that lateral imbalance of masseter muscle activity lead to inhibition of chondrogenesis and induce asymmetric formation of the condyle during the growth period.

Cited by 19 publications

References 49 publications

Masseter muscle atrophy impairs bone quality of the mandibular condyle but not the alveolar process early after induction

Masseter muscle atrophy impairs bone quality of the mandibular condyle but not the alveolar process early after induction

Effects of masticatory muscle function affected by BTX on maxillofacial bone growth through the sutural modification

Micro-CT–Based Bone Microarchitecture Analysis of the Murine Skull

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