The Illness Burden of Knee Osteoarthritis in China: A Prospective Study

Abstract

curve (ROC) methods to minimize misclassification bias. As the positive predictive value (PPV) increased when II was calculated by tertile (T) of baseline severity, we report those results. Results: Sample mean age was 65.1 years (range 43e90) and 55% were female. 80% reported at least one comorbid condition. For pain, T1 (mean 26.0, range 0e35) the II was 45; T2 (mean 48.7, range 40e55) the II was 30; and, T3 (mean 71.1, range 60e100) the II was 25. The overall PPV was 0.92. For function, T1 (mean 29.1, range 0e41) the II was 37; T2 (mean 50.6, range 43e59) the II was 20; and, T3 (mean 71.3, range 60e99) the II was 17. The overall PPV was 0.91. For higher demand activities, T1 (mean 49.3, range 18.7e56.2) the II was 8.8; T2 (mean 61.7, range 56.8e66.4) the II was 8.8; and, T3 (mean 75.6, range 67.3e100) the II was 5.3. The overall PPV was 0.87. Overall, 62%, 77% and 74% achieved the II for pain, function and high demand activities. The vast majority of participants responded 'yes' to the PASS anchor question (only 28, 29 and 33 (<15%) participants reported 'no' for pain, function and higher demand activities respectively) precluding PASS calculation by baseline severity. The PASS for each of pain, function and higher demand activities were 65.0, 68.0 and 70.2/100 respectively based on ROC analyses. The PPV ranged from 0.97e0.98. Conclusions: This work quantifies the II for the WOMAC pain and function subscales and, for the first time, for higher demand activities as measured by the LLDI limitations subscale. These II values accurately classified between 87 and 92% of participants. Given the known large effect for many with TKR, we determined cut-points based on a 'good deal better or more' resulting in somewhat higher values than those reported in some literature depending on baseline severity. Unlike

LncRNA ANCR is positively correlated with transforming growth factor‐β1 in patients with osteoarthritis

“…With the growing aging population in China, the incidence of osteoarthritis is predicted to significantly increase in the near future . Osteoarthritis now has become a heavy burden on public health in China . The pathogenesis of osteoarthritis is a complex network composed of interactions between anabolic, catabolic, and inflammatory signals, while the genetic factors involved are poorly characterized .…”

“…2,3 Osteoarthritis now has become a heavy burden on public health in China. 4 The pathogenesis of osteoarthritis is a complex network composed of interactions between anabolic, catabolic, and inflammatory signals, while the genetic factors involved are poorly characterized. 5 A deeper understanding of the molecular pathogenesis of osteoarthritis is required for the treatment of this disease.…”

Efficacy and safety of Tuina (Chinese Therapeutic Massage) for knee osteoarthritis: A randomized, controlled, and crossover design clinical trial

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Analysis of differentially expressed genes and biological information between rheumatoid arthritis and osteoarthritis based on the GEO database

“…Similarly, knee osteoarthritis (OA) is a common chronic osteoarticular disease characterized by articular cartilage degeneration and joint pain, and the main manifestations of OA include stiffness and pain at the affected part as well as limited mobility [ 6] . The OA disease population is concentrated in women over 65 years old, and it has become one of the major disability diseases among the elderly in China [ 7] . A variety of mechanisms are involved in the pathogenesis of OA, including increased proteases and release of tumour necrosis factor.…”