The IL-27 p28 subunit binds CLF to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling

Crabé, Sandrine; Guay-Giroux, Angélique; Tormo, Aurélie Jeanne; Duluc, Dorothée; Lissilaa, Rami; Guilhot, Florence; Mavoungou-Bigouagou, Ulrick; Lefouili, Fouad; Cognet, Isabelle; Ferlin, Walter; Elson, Greg; Jeannin, Pascale; Gauchat, Jean‐François

doi:10.1016/j.cyto.2009.07.100

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“…The levels of p28 and EBI3 mRNA expressed in Foxp3 À CD11a hi CD49d hi CD4 + cells were also significantly higher than those expressed in macrophages and dendritic cells from the same infected mice 6 days after infection, and were comparable to the highest levels expressed in macrophages on day 4 of the infection when few Foxp3 À CD11a hi CD49d hi CD4 + cells were available ( Figure 3G, Figure S4A). However, while p28 was reported to be able to form a complex with cytokine-like factor 1 (CLF1) (Crabé et al, 2009), we were unable to detect its expression in CD4 + T cells of infected mice ( Figures S4B and S4C). These results indicated that Plasmodium-specific CD4 + T cells are able to produce both p28 and EBI3 in response to TCR engagement.…”

Section: Malaria-specific Cd4 + T Cells Produce Il-27mentioning

confidence: 74%

Interleukin-27-Producing CD4+ T Cells Regulate Protective Immunity during Malaria Parasite Infection

et al. 2016

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Interleukin-27 (IL-27) is a heterodimeric regulatory cytokine of the IL-12 family, which is produced by macrophages, dendritic cells, and B cells upon stimulation through innate immune receptors. Here, we described regulatory CD4(+) T cells that produce IL-27 in response to T cell receptor stimulation during malaria infection, inhibiting IL-2 production and clonal expansion of other T cells in an IL-27-dependent manner. IL-27-producing CD4(+) T cells were Foxp3(-)CD11a(+)CD49d(+) malaria antigen-specific CD4(+) T cells and were distinct from interferon-γ (IFN-γ) producing Th1 or IL-10 producing Tr1 cells. In mice lacking IL-27 in T cells, IL-2 production was restored and clonal expansion and IFN-γ production by specific CD4(+) T cells were improved, culminating in reduced parasite burden. This study highlights a unique population of IL-27 producing regulatory CD4(+) T cells and their critical role in the regulation of the protective immune response against malaria parasites.

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Section: Malaria-specific Cd4 + T Cells Produce Il-27mentioning

confidence: 74%