The IL-2/IL-2 Receptor System. Involvement of a Novel Receptor Subunit, .GAMMA. Chain, in Growth Signal Transduction.

Sugamura, Kazuo; Takeshita, Toru; Asao, Hironobu; Kumaki, Satoru; Ohbo, Kazuyuki; Ohtani, Kiyoshi; Nakamura, M

doi:10.1620/tjem.168.231

Cited by 14 publications

(6 citation statements)

References 7 publications

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“…IL-2 signals through a heterotrimeric receptor composed of IL-2Ra, IL-2Rb, and the g common (gc) chain subunits (2)(3)(4)(5)(6)(7)(8). Expression of individual subunits varies across immune cell populations, and expression levels are dependent upon both immune cell activation state and cytokine signals.…”

Section: Structure Binding Affinity and Regulation Of The Il-2rmentioning

confidence: 99%

Dynamic Roles for IL-2–STAT5 Signaling in Effector and Regulatory CD4+ T Cell Populations

Jones

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Oestreich

2020

The Journal of Immunology

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Section: Structure Binding Affinity and Regulation Of The Il-2rmentioning

confidence: 99%

Dynamic Roles for IL-2–STAT5 Signaling in Effector and Regulatory CD4+ T Cell Populations

Jones

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Oestreich

2020

The Journal of Immunology

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“…Since the IL-2R and -15R contain the sameand -subunits, subsequent signal transduction is mediated by the same molecules, Janus kinases 1 and 3 (JAKs1/3) and Signal Transducer and Activator of Transcription 3 and 5 (STATs 3/5) [4,32,33]. JAK1 is recruited to the IL-2R chain, whereas JAK3 is recruited to the IL-2R chain (Fig.…”

Section: Il-15: Receptor and Signallingmentioning

confidence: 99%

Signalling, inflammation and arthritis: Crossed signals: the role of interleukin-15 and -18 in autoimmunity

2008

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Several cytokines are involved in the complex processes ultimately leading to autoimmune diseases. In a preceding review, we have already discussed the role of the IL-12 and -17 families of cytokines. This review is focused on IL-15 and -18. Both these molecules have pro-inflammatory activity and act on many cell types and because of their broad spectrum of activity they play an important role in autoimmunity and disease pathogenesis. Their biological activity is ultimately regulated by the signalling cascades set into motion within their target cells. In this second review, we will, once again, describe the signal transduction pathways activated by these two cytokines and focus on how this relates to the pathogenesis of autoimmune diseases. We will also describe some of the therapeutic approaches that are being investigated to curtail the pro-inflammatory activities of these two molecules.

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“… 25 Importantly, the CD122 and CD132 subunits of the IL-2R are the only subunits capable of intracellular signaling. 26 , 27 …”

Section: Il-2 Receptor Pathways and Melanomamentioning

confidence: 99%

Update on use of aldesleukin for treatment of high-risk metastatic melanoma

Amaria¹,

Reuben²,

Cooper³

et al. 2015

ITT

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High-dose interleukin-2 has been used for the treatment of metastatic melanoma since 1998 based on data proving durable complete responses in up to 10% of treated patients. The immunomodulatory effects of this critical cytokine have been instrumental in the development of immunotherapy for melanoma and other cancers. However, with the advent of new therapies, its use as a front-line agent has come into question. Nonetheless, there is still a role for interleukin-2 as monotherapy, as well as in combination with other agents and in clinical trials. In this article, we review preclinical and clinical data regarding interleukin-2, its pharmacology and mechanism of action, its toxicity profile, and its use in ongoing and planned clinical trials. We also explore the future of this agent within the treatment landscape for melanoma.

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The IL-2/IL-2 Receptor System. Involvement of a Novel Receptor Subunit, .GAMMA. Chain, in Growth Signal Transduction.

Cited by 14 publications

References 7 publications

Dynamic Roles for IL-2–STAT5 Signaling in Effector and Regulatory CD4+ T Cell Populations

Dynamic Roles for IL-2–STAT5 Signaling in Effector and Regulatory CD4+ T Cell Populations

Signalling, inflammation and arthritis: Crossed signals: the role of interleukin-15 and -18 in autoimmunity

Update on use of aldesleukin for treatment of high-risk metastatic melanoma

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