The IL-1 family of cytokines. Do they have a role in scleroderma fibrosis?

Artlett, Carol M.

doi:10.1016/j.imlet.2017.11.012

Cited by 34 publications

(30 citation statements)

References 140 publications

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“…IL-33 is released by dermal fibroblasts ( 3 ). It has been documented that the IL-33/ST2 signaling is associated with abnormal fibroblast proliferation, leukocyte infiltration and morphologic differentiation of human endothelial cells, resulting in increased endothelial permeability, consistently with increased angiogenesis and ECM deposition in vivo ( 65 ).…”

Section: Il-33/st2 Axis In Skin Fibrosismentioning

confidence: 99%

“…IL-33 has been reported to be a crucial signaling cytokine in skin pathology by inducing IL-13-dependent cutaneous fibrosis mechanism, required both eosinophils and recombination-activating gene (RAG)-dependent lymphocytes. Eosinophils contribute to tissue remodeling and fibrosis ( 65 ). It is known that in skin diseases, eosinophil expresses a broad spectrum of Th2 cytokines such as IL-4, IL-5, IL-13, and C-C motif chemokine-11 (CCL11/eotaxin) ( 66 ).…”

Section: Il-33/st2 Axis In Skin Fibrosismentioning

confidence: 99%

“…More convincingly, in cutaneous fibrosis, the injection of rIL-33 induces collagen production via ST2-dependent recruitment of BM-derived eosinophils that further secrete IL-13 in response to IL-33 stimulation ( 22 , 65 ). IL-33 has also been proposed as a critical molecule operating in eosinophil-mediated fibrosis in the high-dose-per fraction irradiated skin ( 66 ).…”

Section: Il-33/st2 Axis In Skin Fibrosismentioning

confidence: 99%

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IL-33/ST2 Axis in Organ Fibrosis

2018

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Interleukin 33 (IL-33) is highly expressed in barrier sites, acting via the suppression of tumorigenicity 2 receptor (ST2). IL-33/ST2 axis has long been known to play a pivotal role in immunity and cell homeostasis by promoting wound healing and tissue repair. However, it is also involved in the loss of balance between extensive inflammation and tissue regeneration lead to remodeling, the hallmark of fibrosis. The aim of the current review is to critically evaluate the available evidence regarding the role of the IL-33/ST2 axis in organ fibrosis. The role of the axis in tissue remodeling is better understood considering its crucial role reported in organ development and regeneration. Generally, the IL-33/ST2 signaling pathway has mainly anti-inflammatory/anti-proliferative effects; however, chronic tissue injury is responsible for pro-fibrogenetic responses. Regarding pulmonary fibrosis mature IL-33 enhances pro-fibrogenic type 2 cytokine production in an ST2- and macrophage-dependent manner, while full-length IL-33 is also implicated in the pulmonary fibrotic process in an ST2-independent, Th2-independent fashion. In liver fibrosis, evidence indicate that when acute and massive liver damage occurs, the release of IL-33 might act as an activator of tissue-protective mechanisms, while in cases of chronic injury IL-33 plays the role of a hepatic fibrotic factor. IL-33 signaling has also been involved in the pathogenesis of acute and chronic pancreatitis. Moreover, IL-33 could be used as an early marker for ulcer-associated activated fibroblasts and myofibroblast trans-differentiation; thus one cannot rule out its potential role in inflammatory bowel disease-associated fibrosis. Similarly, the upregulation of the IL-33/ST2 axismay contribute to tubular cell injury and fibrosis via epithelial to mesenchymal transition (EMT) of various cell types in the kidneys. Of note, IL-33 exerts a cardioprotective role via ST2 signaling, while soluble ST2 has been demonstrated as a marker of myocardial fibrosis. Finally, IL-33 is a crucial cytokine in skin pathology responsible for abnormal fibroblast proliferation, leukocyte infiltration and morphologic differentiation of human endothelial cells. Overall, emerging data support a novel contribution of the IL-33/ST2 pathway in tissue fibrosis and highlight the significant role of the Th2 pattern of immune response in the pathophysiology of organ fibrosis.

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Section: Il-33/st2 Axis In Skin Fibrosismentioning

confidence: 99%

Section: Il-33/st2 Axis In Skin Fibrosismentioning

confidence: 99%

Section: Il-33/st2 Axis In Skin Fibrosismentioning

confidence: 99%

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IL-33/ST2 Axis in Organ Fibrosis

2018

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“…Fibrosis can affect nearly all tissues and organ systems, but often is most present in: inflammatory vessels, skin disease, interstitial lung disease, liver cirrhosis, kidney disease, heart disease, diseases of the eye, atherosclerosis and scleroderma …”

Section: Introductionmentioning

confidence: 99%

Critical role of inflammatory mast cell in fibrosis: Potential therapeutic effect of IL‐37

et al. 2018

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“…유전자들 의 상대적 발현량은 glyceraldehyde-3-phosphate dehydrogenase (GAPDH)를 이용하여 계산하였다. (Kawaguchi et al, 2004;Schwartz et al, 2016;Artlett, 2018 (Gautier et al, 2009). CCR7의 발현량은 사료내 미세조류 첨가수준이 증 가함에 따라 직선적(Linear; P<0.01)으로 증가하는 것을 보 였다.…”

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Supplementation of Indigenous Green Microalga (Parachlorella sp.) to Pre-starter Diet for Broiler Chickens

An¹,

Joo²,

Lee³

et al. 2020

Korean J. Poult. Sci.

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The present study determined the effect of dietary cultivated microalgae (Parachlorella sp.) on the growth and immune responses of pre-starter broilers. A total of 320 one-day-old birds (Ross 308) were allocated to 4 treatments with 8 blocks in a randomized complete block design. The four experimental diets consisted of a corn-soybean meal-based control diet, and three diets contained 0.5%, 1.0%, and 1.5% microalgae powder at the expense of cornstarch in the control diet. After feeding the experimental diets for 7 days, the body weight and feed intake of all birds were measured, and 8 birds were randomly selected from each treatment. Peripheral blood mononuclear cells (PBMCs) and serum were harvested for immune profile assessment, including cytokines and cell migration receptors. No differences in growth performance were observed among the treatments. The birds that were fed diets containing graded levels of microalga showed a linear increase in the mRNA expression of cytokine genes in PBMCs, including that of IL2, IL1β, and IL18 (P<0.05). With respect to the chemokine receptor genes in PBMCs, mRNA expression of CCR2, CCR9, and ITGA4 changed quadratically (P<0.05), but that of CCR7 increased linearly (P<0.01). Cytokine protein secretion in blood, including that of IL-1β and IL-6, increased linearly (P<0.01) with an increase in the microalgal content. Overall, the present results show that the indigenous microalgae powder used in this study could stimulate immunity with no detrimental effects on the growth performance of pre-starter broiler chickens.(

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The IL-1 family of cytokines. Do they have a role in scleroderma fibrosis?

Cited by 34 publications

References 140 publications

IL-33/ST2 Axis in Organ Fibrosis

IL-33/ST2 Axis in Organ Fibrosis

Critical role of inflammatory mast cell in fibrosis: Potential therapeutic effect of IL‐37

Supplementation of Indigenous Green Microalga (Parachlorella sp.) to Pre-starter Diet for Broiler Chickens

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