The Identification of Streptococcus pasteurianus Obtained from Six Regions in China by Multiplex PCR Assay and the Characteristics of Pathogenicity and Antimicrobial Resistance of This Zoonotic Pathogen

Ma, Miaohang; Wang, Shuoyue; Zhu, Xinchi; Li, Xinchun; Bao, Yinli; Chen, Xiang; Wu, Zongfu

doi:10.3390/pathogens12040615

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…In addition, the abundance of the Streptococcaceae family exhibited a specific decrease, with Streptococcus pasteurianus showing the strongest negative correlation with SJ-2 in the co-occurrence network. S. pasteurianus is a potential pathogen for inflammatory diseases, which is known to be enriched in Crohn’s disease but reduced as SCFAs accumulated ( Nagayama et al, 2020 ; Wang et al, 2020 ; Ma et al, 2023 ). Therefore, the negative correlation between SJ-2 and S. pasteurianus may be attributed to the efficient SCFAs production of C. minuta ( Kropp et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Christensenella minuta interacts with multiple gut bacteria

Xu,

Jiang,

Feng

et al. 2024

Front. Microbiol.

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IntroductionGut microbes form complex networks that significantly influence host health and disease treatment. Interventions with the probiotic bacteria on the gut microbiota have been demonstrated to improve host well-being. As a representative of next-generation probiotics, Christensenella minuta (C. minuta) plays a critical role in regulating energy balance and metabolic homeostasis in human bodies, showing potential in treating metabolic disorders and reducing inflammation. However, interactions of C. minuta with the members of the networked gut microbiota have rarely been explored.MethodsIn this study, we investigated the impact of C. minuta on fecal microbiota via metagenomic sequencing, focusing on retrieving bacterial strains and coculture assays of C. minuta with associated microbial partners.ResultsOur results showed that C. minuta intervention significantly reduced the diversity of fecal microorganisms, but specifically enhanced some groups of bacteria, such as Lactobacillaceae. C. minuta selectively enriched bacterial pathways that compensated for its metabolic defects on vitamin B1, B12, serine, and glutamate synthesis. Meanwhile, C. minuta cross-feeds Faecalibacterium prausnitzii and other bacteria via the production of arginine, branched-chain amino acids, fumaric acids and short-chain fatty acids (SCFAs), such as acetic. Both metagenomic data analysis and culture experiments revealed that C. minuta negatively correlated with Klebsiella pneumoniae and 14 other bacterial taxa, while positively correlated with F. prausnitzii. Our results advance our comprehension of C. minuta’s in modulating the gut microbial network.ConclusionsC. minuta disrupts the composition of the fecal microbiota. This disturbance is manifested through cross-feeding, nutritional competition, and supplementation of its own metabolic deficiencies, resulting in the specific enrichment or inhibition of the growth of certain bacteria. This study will shed light on the application of C. minuta as a probiotic for effective interventions on gut microbiomes and improvement of host health.

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Section: Discussionmentioning

confidence: 99%

Christensenella minuta interacts with multiple gut bacteria

Xu,

Jiang,

Feng

et al. 2024

Front. Microbiol.

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Streptococcosis

Shehata,

Hafez

2024

Turkey Diseases and Disorders Volume 1

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Late-Onset Meningitis in a Preterm Infant Caused by Streptococcus gallolyticus Subsp. Pasteurianus in Saudi Arabia: A Case Report and Literature Review

Al-shehri

2023

IMCRJ

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This report describes the progression of meningitis in a 24-day-old preterm male infant infected with Streptococcus gallolyticus subsp. pasteurianus (SGSP) and its medical care, pathogen detection, antibiotic treatment, and monitoring, ultimately leading to a positive outcome of successful recovery. Neonatal meningitis (NM) is a serious and potentially life-threatening condition, particularly in immunocompromised preterm infants. This report from Saudi Arabia presents a rare case of late-onset neonatal meningitis caused by SGSP in a preterm male infant. The 24-day-old preterm neonate presented with fever, lethargy, poor feeding, and respiratory distress. SGSP was confirmed by cerebral spinal fluid analysis showing the presence of pleocytosis and a low glucose ratio. Prompt antibiotic therapy with intravenous Ampicillin and Cefotaxime led to decreased pleocytosis, and the infant was discharged after 21 days. This report highlights the importance of vigilance, diagnosis, and management of neonatal infections caused by uncommon pathogens such as SGSP. The rarity of SGSP-caused meningitis emphasizes the need to monitor pregnant women for potential transmission and to implement early diagnostic and management strategies. This case report also encompasses a review of recent globally reported cases of neonatal S. gallolyticus infection, highlighting the distinctiveness of this report as the first of its type in Saudi Arabia.

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The Identification of Streptococcus pasteurianus Obtained from Six Regions in China by Multiplex PCR Assay and the Characteristics of Pathogenicity and Antimicrobial Resistance of This Zoonotic Pathogen

Cited by 3 publications

References 56 publications

Christensenella minuta interacts with multiple gut bacteria

Christensenella minuta interacts with multiple gut bacteria

Streptococcosis

Late-Onset Meningitis in a Preterm Infant Caused by Streptococcus gallolyticus Subsp. Pasteurianus in Saudi Arabia: A Case Report and Literature Review

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