The identification of a novel shared therapeutic target and drug across all insulin-sensitive tissues under insulin resistance
Jinyuan Xu,
Lilin Zhu,
Jie Xu
et al.
Abstract:BackgroundTo identify key and shared insulin resistance (IR) molecular signatures across all insulin-sensitive tissues (ISTs), and their potential targeted drugs.MethodsThree datasets from Gene Expression Omnibus (GEO) were acquired, in which the ISTs (fat, muscle, and liver) were from the same individual with obese mice. Integrated bioinformatics analysis was performed to obtain the differentially expressed genes (DEGs). Weighted gene co-expression network analysis (WGCNA) was carried out to determine the “mo… Show more
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