I this paper, we survey and focus on developments in the chemistry curriculum in Israel over the past 70 years, as influenced by changes and reforms in the curricula around the world and specifically in the United States, by political, cultural and socio-economic factors, scientific and technological innovations, and theories and studies in learning and teaching. The mentioned studies refer also to the influence of the learners, the teachers, the content, the pedagogy of teaching and learning both in and out of school, and the assessment of students' achievement on the curriculum changes. Three periods of changes are discussed in the chemistry curriculum in Israel, from the 1960s to the beginning of the 21 st century, as influenced by the above factors.