2000
DOI: 10.1016/s0304-4017(00)00223-5
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The Ibizian hound presents a predominantly cellular immune response against natural Leishmania infection

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Cited by 173 publications
(150 citation statements)
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“…The Ibizan Hound breed has been reported to be resistant to CVL due to its strong cellular response to the infection [28]. In the Ibizan Hound cohort no dog has been affected with CVL, and, interestingly, six Slc11a1 haplotypes appear to be specific to this breed.…”
Section: Discussionmentioning
confidence: 96%
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“…The Ibizan Hound breed has been reported to be resistant to CVL due to its strong cellular response to the infection [28]. In the Ibizan Hound cohort no dog has been affected with CVL, and, interestingly, six Slc11a1 haplotypes appear to be specific to this breed.…”
Section: Discussionmentioning
confidence: 96%
“…Although associations had also been described in the dog between this gene and canine visceral leishmaniasis (CVL) [1,19,23], the current study further characterized the canine Slc11a1 gene and attempted to determine the genetic susceptibility to Leishmania infection among dogs and the risk for CVL. Sequencing the canine Slc11a1 gene, we identified 19 new polymorphisms among 40 dogs from 11 different breeds and we analyzed them in 164 dogs from 19 different breeds in a case-control study and a cohort of 58 Ibizan Hounds, a breed that has been described as resistant to CVL [28]. Data analysis revealed that three of the 24 polymorphisms found in the Slc11a1 gene were associated with increased risk for CVL.…”
Section: Discussionmentioning
confidence: 99%
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