The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer

Goldstraw, Peter; Chansky, Kari; Crowley, John; Rami‐Porta, Ramón; Asamura, Hisao; Eberhardt, Wilfried; Nicholson, Andrew G.; Groome, Patti A.; Mitchell, Alan; Bolejack, Vanessa; Beer, David G.; Beyruti, Ricardo; Detterbeck, Frank C.; Edwards, John; Galateau-Sallé, Françoise; Giroux, Dorothy J.; Gleeson, Fergus; Huang, James; Kim, Young Tae; Kingsbury, Laura; Kondo, Haruhiko; Krasnik, Mark; Kubota, Keiichi; Lerut, Antoon; Marino, Mirella; Marom, Edith M.; Meerbeeck, Jan P. van; Nakano, Takashi; Nowak, Anna K.; Peake, Michael; Rice, Thomas W.; Rosenzweig, Kenneth E.; Ruffini, Enrico; Rusch, Valerie W.; Saijo, Nagahiro; Schil, Paul Van; Sculier, Jean-Paul; Shemanski, Lynn; Stratton, Kelly; Suzuki, Kenji; Tachimori, Yuji; Travis, William D.; Tsao, Ming‐Sound; Turrisi, Andrew T.; Vansteenkiste, Johan; Watanabe, Hirokazu; Wu, Yi‐Long; Baas, Paul; Erasmus, Jeremy J.; Hasegawa, Seiki; Inai, Kei; Kernstine, Kemp H.; Kindler, Hedy L.; Krug, Lee M.; Nackaerts, Kristiaan; Pass, Harvey I.; Rice, David C.; Falkson, Conrad; Filosso, Pier Luigi; Giaccone, Giuseppe; Kondo, Kazuya; Lucchi, Marco; Okumura, Meinoshin; Blackstone, Eugene H.; Cavaco, F. Abad; Barrera, Emilio Ansótegui; Arca, José Abal; Lamelas, Isaura Parente; Obrer, A. Arnau; Jorge, Ricardo; Ball, David; Bascom, George; Orozco, Ana Isabel Blanco; Castro, Mary Ames; Blum, Matthew G.; Chimondeguy, Domingo; Cvijanović, Vlado; Defranchi, Sebastián; Navarro, Beatriz de Olaiz; Campuzano, Ignacio Escobar; Macía, Iván; Araujo, E. Fernández; García, Felipe Andreo; Fong, Kwun M.; Corral, Gloria Francisco; González, S. Cerezo; Gilart, Jorge Freixinet; Arangüena, Luis García; Barajas, S. García; Girard, Philippe; Göksel, Tuncay; Budiño, Ma Teresa González; Casaurrán, Guillermo González; Blanco, José Antonio Gullón; Hernández, Jesús Hernández; Rodríguez, Helena Hernández; Collantes, Jorge Herrero; Heras, Manuel Macía; Elena, José Miguel Izquierdo; Jakobsen, Erik; Kostas, Syrigos N; Atance, Pablo León; Ares, Ana Núñez; Liao, Mei Lin; Losanovscky, M.; Lyons, Gustavo; Magaroles, R.; Júlvez, L. De Esteban; Gorospe, M. Mariñán; McCaughan, Brian C.; Kennedy, Catherine; Íñiguez, Rosario Melchor; Sorribes, Luis Miravet; Gozalo, Sara Naranjo; Arriba, C. Álvarez de; Delgado, Manuel Núñez; Alarcón, José Padilla; Cuesta, Juan Carlos Peñalver; Park, James S.; Fernández, Ma José Pavón; Rosenberg, M; Escuín, Julio Sánchez de Cos; Vinuesa, Angels; Mitjans, Montserrat; Strand, Trond Eirik; Subotic, Dragan; Swisher, Stephen G.; Terra, Ricardo Mingarini; Thomas, Charles F.; Tournoy, Kurt G.; Velásquez, Mauricio; Wu, Yijun; Yokoi, Kohei

doi:10.1016/j.jtho.2015.09.009

Cited by 3,201 publications

(2,109 citation statements)

References 19 publications

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“…Both the Danish -and the present populations are taken care of by national health services who provide universal, tax-supported health care, guaranteeing unconstrained access to general practitioners and hospitals. Further, the overall survival in our study was in line with estimates from the International Association for the Study of Lung Cancer [80]. These nearly identical findings may to some degree support and confirm the external validity of our results.…”

Section: Discussion Of Main Resultssupporting

confidence: 91%

Survival After Surgical Resection for Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease

Bugge

Lund

Brunborg

et al. 2016

The Annals of Thoracic Surgery

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Section: Discussion Of Main Resultssupporting

confidence: 91%

Survival After Surgical Resection for Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease

Bugge

Lund

Brunborg

et al. 2016

The Annals of Thoracic Surgery

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“…The current eighth edition of NSCLC regarded LNs staging as a creditable prognostic factor, and LNs staging is based on the location of invaded LNs regardless of the number of PLNs 12. However, the updated pathological TNM stage of colorectal and breast cancer had deemed PLNs as novel criteria 13.…”

Section: Discussionmentioning

confidence: 99%

Prognosis and distribution of lymph nodes metastases in resectable primary pulmonary lymphoepithelioma‐like carcinoma: A large cohort from a single center

Wen

Qin

et al. 2018

Thoracic Cancer

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BackgroundPrimary pulmonary lymphoepithelioma‐like carcinoma is a rare subtype of lung cancer. Until now, the characteristics of lymph nodes metastases in resectable cases have not yet been reported.MethodsIn this study, a total of 87 consecutive patients with primary pulmonary lymphoepithelioma‐like carcinoma that received surgical treatment were investigated from October 1999 to August 2016. The clinical and radiological data and follow‐up information were extracted from hospital records in detail.ResultsIn a univariate analysis, those patients with an early pathological stage (I–II), low rate of lymph node metastases (<30%) and a low number of positive lymph nodes (<5) showed longer recurrence‐free survival and overall survival (all P < 0.05). However, the early pathological stage was identified as the only factor independently associated with recurrence‐free survival by multivariate analysis (P = 0.038). In a preoperative lymph nodes evaluation, the accuracy and specificity of computed tomography alone were 52.9% (46/87) and 88% (302/343), respectively, and 73.2% of these cases with incorrect nodal staging (30/41) were upstaged. Skipping metastases were more frequent in operated stage N2 cases (71.4%), whereas whether or not those patients showed skipping metastasis did not affect their recurrence‐free survival or overall survival (P > 0.05). The highest metastasis frequencies for specific lobes with primary lymphoepithelioma‐like carcinoma are as follows: #5 left upper lobe (21.4%); #7 left lower lobe (40.7%); #2R (28.6%) and/or #4R (14.3%) right upper lobe; #7 (42.9%) right lower lobe; #7 (28%) and/or superior mediastinal nodes (36%) right middle lobe.ConclusionBased on accurate staging and uncertain survival benefit, complete mediastinal lymph nodes dissection is still required for curative resection.

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“…In conclusion: (1) patient survival after wedge/ sublobar resection of stage I NSCLC is improving, and is not significantly different globally for peripheral small-sized tumors; (2) there are phase III studies comparing lobectomy and segmentectomy but not wedge resection; (3) survival probability of wedge resection seems to be similar to that of SBRT, but SBRT has limitations such as "no-fly-zone", irradiation of hilar tumors and associated complications such as pulmonary fibrosis and hemoptysis; and (4) a suitable subgroup of patients for wedge/sublobar resection may be found based on tumor size, location, margindistance, M/T ratio, and margin cytology.…”

Section: [60]mentioning

confidence: 93%

“…[1] Because stage I lung cancer is a localized disease without evidence of metastases [2] and is associated with low morbidity and mortality, minimally invasive (mini-invasive) local therapies are central to managing the high-risk or medically unfit patent such as the elderly. The various types of mini-invasive local therapies for stage I lung cancer are defined by the amount of lung tissue targeted or resected.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary wedge resection for clinical stage I non-small cell lung cancer: a review of a mini-invasive treatment

Sawabata¹,

Kawase²,

Takahashi³

et al. 2017

MIS

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Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths in the world. Therefore, there is a need to intensify treatments of these tumors. Because stage I NSCLC is a nonmetastatic disease, local therapies are indicated, among which surgery is the most commonly deployed strategy. Pulmonary wedge/sublobar resection is therefore discussed in comparison to stereotactic body radiation therapy for stage I lung cancer. Review of retrospective and prospective clinical trials reveal similar outcomes for both strategies, while a multicenter randomized prospective study comparing the efficacy of both therapies is on-going. Because the results of pulmonary wedge/sublobar resection may depend on tumor size, tumor-distance from surgical margin, tumor size-to-margin distance ratio, and margin cytology, prospective studies to evaluate the clinical implications of these factors, so as to inform patient prognostication, are recommended. Key words:Non-small cell lung cancer, wedge resection, sublobar resection, stage I, stereotactic body radiation therapy ABSTRACTArticle history:

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The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer

Cited by 3,201 publications

References 19 publications

Survival After Surgical Resection for Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease

Survival After Surgical Resection for Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease

Prognosis and distribution of lymph nodes metastases in resectable primary pulmonary lymphoepithelioma‐like carcinoma: A large cohort from a single center

Pulmonary wedge resection for clinical stage I non-small cell lung cancer: a review of a mini-invasive treatment

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