The YIG1 (YPL201c) encoded protein is involved in regulating anaerobic glycerol metabolism in Saccharomyces cerevisiae

Granath, Katarina; Modig, Tobias; Forsmark, Annabelle; Adler, Lennart; Lidén, Gunnar

doi:10.1002/yea.1307

Cited by 3 publications

(2 citation statements)

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“…The difference between these two isoenzymes may be explained by the fact that Rhr2 is the predominant isoenzyme in the cell [31]. In agreement with the major role of Rhr2, the mRNA level of YIG1 , coding for an inhibitor of Rhr2 [32], was down-regulated in all long-lived mutants (Figure 3B). Notably, the life span of rhr2 Δ mutants in the BY4741 genetic background was similar to that of wild type cells, although some rhr2 Δ cultures showed regrowth/gasping (data not shown) [33].…”

Section: Resultssupporting

confidence: 67%

Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension

et al. 2009

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The effect of calorie restriction (CR) on life span extension, demonstrated in organisms ranging from yeast to mice, may involve the down-regulation of pathways, including Tor, Akt, and Ras. Here, we present data suggesting that yeast Tor1 and Sch9 (a homolog of the mammalian kinases Akt and S6K) is a central component of a network that controls a common set of genes implicated in a metabolic switch from the TCA cycle and respiration to glycolysis and glycerol biosynthesis. During chronological survival, mutants lacking SCH9 depleted extracellular ethanol and reduced stored lipids, but synthesized and released glycerol. Deletion of the glycerol biosynthesis genes GPD1, GPD2, or RHR2, among the most up-regulated in long-lived sch9Δ, tor1Δ, and ras2Δ mutants, was sufficient to reverse chronological life span extension in sch9Δ mutants, suggesting that glycerol production, in addition to the regulation of stress resistance systems, optimizes life span extension. Glycerol, unlike glucose or ethanol, did not adversely affect the life span extension induced by calorie restriction or starvation, suggesting that carbon source substitution may represent an alternative to calorie restriction as a strategy to delay aging.

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Section: Resultssupporting

confidence: 67%

Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension

et al. 2009

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“…It participates in the respiratory chain and provides information for synthesis of a protein encoded by mitochondrial DNA that is essential for normal mitochondrial function. YIG1 [ 34 ] encodes protein and is involved in regulating anaerobic glycerol metabolism in Saccharomyces cerevisiae . Deletion or overexpression of YIG1 significantly affects growth yield or glycerol yield in anaerobic batch cultures.…”

Section: Discussionmentioning

confidence: 99%

Modeling Gene Networks inSaccharomyces cerevisiaeBased on Gene Expression Profiles

Zhang

Wang

et al. 2015

Computational and Mathematical Methods in Medicine

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Detailed and innovative analysis of gene regulatory network structures may reveal novel insights to biological mechanisms. Here we study how gene regulatory network in Saccharomyces cerevisiae can differ under aerobic and anaerobic conditions. To achieve this, we discretized the gene expression profiles and calculated the self-entropy of down- and upregulation of gene expression as well as joint entropy. Based on these quantities the uncertainty coefficient was calculated for each gene triplet, following which, separate gene logic networks were constructed for the aerobic and anaerobic conditions. Four structural parameters such as average degree, average clustering coefficient, average shortest path, and average betweenness were used to compare the structure of the corresponding aerobic and anaerobic logic networks. Five genes were identified to be putative key components of the two energy metabolisms. Furthermore, community analysis using the Newman fast algorithm revealed two significant communities for the aerobic but only one for the anaerobic network. David Gene Functional Classification suggests that, under aerobic conditions, one such community reflects the cell cycle and cell replication, while the other one is linked to the mitochondrial respiratory chain function.

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Current awareness on yeast

2006

Yeast

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The diagnosis of Angelman syndrome (AS) can be confirmed by genetic laboratory in about 80% of cases. In 20%, the diagnosis remains clinical, but often there is uncertainty about the correctness of the clinical diagnosis and alternative diagnoses may be investigated. In evaluating individuals for AS in our center since 1989, we have encountered several mimicking conditions, and additional ones have been reported in the literature. Mimicking conditions can be grouped into the areas of chromosome, single gene, and symptom complex anomalies. Microdeletions or microduplications include chromosome regions 2,4,17, 22, and 15. Single gene conditions include methylene tetrahydrofolate reductase deficiency (MTHFR), Rett syndrome, alpha‐thalassemia retardation syndrome (ATR‐X), and Gurrieri syndrome. Symptom complexes include cerebral palsy, static encephalopathy, Lennox‐Gastaut syndrome, autism spectrum disorder, pervasive developmental delay (PDD), and mitochondrial disorders. We present a review of these mimicking disorders to increase the awareness about conditions that can lead to an incorrect clinical diagnosis of AS. © 2001 Wiley‐Liss, Inc.

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The YIG1 (YPL201c) encoded protein is involved in regulating anaerobic glycerol metabolism in Saccharomyces cerevisiae

Cited by 3 publications

References 46 publications

Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension

Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension

Modeling Gene Networks inSaccharomyces cerevisiaeBased on Gene Expression Profiles

Current awareness on yeast

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