TheWnt/β-catenin/TCF/Sp5/Zic4gene network that regulates head organizer activity inHydrais differentially regulated in epidermis and gastrodermis
Laura Iglesias Ollé,
Chrystelle Perruchoud,
Paul Gerald Layague Sanchez
et al.
Abstract:In Hydra, head formation depends on Wnt/β-catenin signaling, which positively regulates Sp5 and Zic4, with Sp5 limiting Wnt3/β-catenin expression and Zic4 triggering tentacle formation. Using transgenic lines in which the HySp5 promoter drives eGFP expression in the epidermis or gastrodermis, we show that in intact animals, epidermal HySp5:GFP is expressed strongly apically and weakly along the body column, while gastrodermal HySp5:GFP is also maximally expressed apically but absent from the oral region, and r… Show more
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