The
            <i>sloABCR</i>
            Operon of
            <i>Streptococcusmutans</i>
            Encodes an Mn and Fe Transport System Required forEndocarditis Virulence and Its Mn-DependentRepressor

Paik, Sehmi; Brown, Arunsri; Munro, Cindy L.; Cornelissen, Cynthia Nau; Kitten, Todd

doi:10.1128/jb.185.24.7301.2003

Cited by 33 publications

(59 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous study from our group showed that the high affinity manganese transporter, SsaB, is essential for O 2 tolerance and endocarditis virulence in S. sanguinis (26). This mirrored earlier findings showing that orthologs of this transporter are essential for endocarditis caused by other oral streptococci (29,30) for pneumonia, bacteremia, and otitis media caused by Streptococcus pneumoniae (31)(32)(33)(34), for bacteremia caused by S. pyogenes (35), and for mastitis caused by Streptococcus uberis (36). It is known that Mn II contributes to O 2 tolerance in part by serving as a cofactor for the superoxide dismutase SodA.…”

Section: Discussionsupporting

confidence: 77%

Genetic Characterization and Role in Virulence of the Ribonucleotide Reductases of Streptococcus sanguinis

Rhodes

Crump

Makhlynets³

et al. 2014

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 77%

Genetic Characterization and Role in Virulence of the Ribonucleotide Reductases of Streptococcus sanguinis

Rhodes

Crump

Makhlynets³

et al. 2014

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

“…The other protein was a homologue of SloA (Smut0164), a protein associated with Mn and Fe uptake in S. mutans encoded by the sloABCR operon. SloA forms part of an ABC transport complex that belongs to the lipoprotein receptor antigen I (LraI) family, as the lipoprotein ionbinding component of this transport system, SloC, is antigenic and a known virulence trait in infective endocarditis (Kitten et al, 2000;Paik et al, 2003). In biofilmgrown cells, SloA was down-regulated 2?3±0?6-fold ( Table 2).…”

Section: Or Biofilm-grown Cells (Dots)mentioning

confidence: 95%

Up-regulation of competence- but not stress-responsive proteins accompanies an altered metabolic phenotype in Streptococcus mutans biofilms

et al. 2005

View full text Add to dashboard Cite

Mature biofilm and planktonic cells of Streptococcus mutans cultured in a neutral pH environment were subjected to comparative proteome analysis. Of the 242 protein spots identified, 48 were significantly altered in their level of expression (P<0?050) or were unique to planktonic or biofilm-grown cells. Among these were four hypothetical proteins as well as proteins known to be associated with the maintenance of competence or found to possess a cin-box-like element upstream of their coding gene. Most notable among the non-responsive genes were those encoding the molecular chaperones DnaK, GroEL and GroES, which are considered to be up-regulated by sessile growth. Analysis of the rest of the proteome indicated that a number of cellular functions associated with carbon uptake and cell division were down-regulated. The data obtained were consistent with the hypothesis that a reduction in the general growth rate of mature biofilms of S. mutans in a neutral pH environment is associated with the maintenance of transformation without the concomitant stress response observed during the transient state of competence in bacterial batch cultures.

show abstract

“…PsaA/ScaA homologues have been identified in at least nine additional species of Streptococcus and also in bacteria belonging to other genera (for a review see Claverys, 2001). Mn 2+ uptake by ABC transporters has been experimentally demonstrated in Salmonella enterica serovar Typhimurium (Kehres et al, 2002;Kehres & Maguire, 2003) and specificity for both iron and manganese was shown for Yersinia pestis (Bearden & Perry, 1999), S. pyogenes (Janulczyk et al, 2003) and Streptococcus mutans (Paik et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Genome-based in silico detection of putative manganese transport systems in Lactobacillus plantarum and their genetic analysis

et al. 2005

View full text Add to dashboard Cite

Manganese serves an important function in Lactobacillus plantarum in protection against oxidative stress and this bacterium can accumulate Mn 2+ up to millimolar levels intracellularly.Although the physiological role of Mn 2+ and the uptake of this metal ion have been well documented, the only uptake system described so far for this bacterium is the Mn 2+ -and Cd 2+-specific P-type ATPase (MntA). Recently, the genome of L. plantarum WCFS1 has been sequenced allowing in silico detection of genes potentially encoding Mn 2+ transport systems, using established microbial Mn 2+ transporters as the query sequence. This genome analysis revealed that L. plantarum WCFS1 encodes, besides the previously described mntA gene, an ABC transport system (mtsCBA) and three genes encoding Nramp transporters (mntH1, mntH2 and mntH3).

show abstract

The sloABCR Operon of Streptococcusmutans Encodes an Mn and Fe Transport System Required forEndocarditis Virulence and Its Mn-DependentRepressor

Cited by 33 publications

References 0 publications

Genetic Characterization and Role in Virulence of the Ribonucleotide Reductases of Streptococcus sanguinis

Genetic Characterization and Role in Virulence of the Ribonucleotide Reductases of Streptococcus sanguinis

Up-regulation of competence- but not stress-responsive proteins accompanies an altered metabolic phenotype in Streptococcus mutans biofilms

Genome-based in silico detection of putative manganese transport systems in Lactobacillus plantarum and their genetic analysis

Contact Info

Product

Resources

About