1999
DOI: 10.1111/j.1574-6968.1999.tb13707.x
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Thesaelocus ofStaphylococcus aureusencodes a two-component regulatory system

Abstract: Sae is a regulatory locus that activates the production of several exoproteins in Staphylococcus aureus. A 3.4-kb fragment of a S. aureus genomic library, screened with a probe adjacent to the transposon insertion of a sae::Tn551 mutant, was cloned into a bifunctional vector. This fragment was shown to carry the sae locus by restoration of exoprotein production in sae mutants. The sae locus was mapped to the SmaI-D fragment of the staphylococcal chromosome by pulse-field electrophoresis. Sequence analysis of t… Show more

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Cited by 147 publications
(57 citation statements)
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References 19 publications
(29 reference statements)
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“…SaeS is composed of 351 aa where His131 is the phosphorylation site [13]. As a sensor histidine kinase, its kinase activity determines the level of SaeR-P, the effector molecule of the SaeRS TCS.…”
Section: Components Of the Saers Tcsmentioning
confidence: 99%
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“…SaeS is composed of 351 aa where His131 is the phosphorylation site [13]. As a sensor histidine kinase, its kinase activity determines the level of SaeR-P, the effector molecule of the SaeRS TCS.…”
Section: Components Of the Saers Tcsmentioning
confidence: 99%
“…For example, agr mutation reduced both the sae P1 promoter activity and the Sae mRNA level [13,14,15,79]. In the strain ISP479, a derivative of the strain 8325-4, an agr mutation greatly reduced the sae P3 promoter function in the 1.15 kb fragment upstream of saeR [80].…”
Section: Interaction With Other Regulatorsmentioning
confidence: 99%
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“…The well-studied global and TCSs virulence regulators include Agr (Novick, 2003; Montgomery et al, 2010; Thoendel and Horswill, 2013), ArlRS (Fournier et al, 2001; Bronner et al, 2004; Liang et al, 2005), SaeRS (Giraudo et al, 1999; Liang et al, 2006; Voyich et al, 2009; Nygaard et al, 2010; Zurek et al, 2014; Liu et al, 2016), SarA (Chien et al, 1999; Cheung et al, 2008; Li et al, 2016; Loughran et al, 2016), and MgrA (Ballal et al, 2009; Gupta et al, 2015). …”
Section: Introductionmentioning
confidence: 99%