1998
DOI: 10.1101/gad.12.21.3452
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The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice

Abstract: The Drosophila svb/ovo gene gives rise to differentially expressed transcripts encoding a zinc finger protein. svb/ovo has two distinct genetic functions: shavenbaby (svb) is required for proper formation of extracellular projections that are produced by certain epidermal cells in late-stage differentiation; ovo is required for survival and differentiation of female germ cells. We cloned a mouse gene, movo1 encoding a nuclear transcription factor that is highly similar to its fly counterpart in its zinc-finger… Show more

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Cited by 139 publications
(185 citation statements)
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“…So far, three ovo family members have been functionally characterized. Drosophila melanogaster ovo and mouse Ovol1 (also known as movo1) are required for germ cell and epidermal appendage differentiation [2][3][4][5][6], whereas mutations in Caenorhabditis elegans ovo do not produce apparent fertility or epidermal defects, but instead cause defects in hindgut (the counterpart of mammalian urogenital system, where defects are found in Ovol1 mutant mice) [7].…”
Section: Introductionmentioning
confidence: 99%
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“…So far, three ovo family members have been functionally characterized. Drosophila melanogaster ovo and mouse Ovol1 (also known as movo1) are required for germ cell and epidermal appendage differentiation [2][3][4][5][6], whereas mutations in Caenorhabditis elegans ovo do not produce apparent fertility or epidermal defects, but instead cause defects in hindgut (the counterpart of mammalian urogenital system, where defects are found in Ovol1 mutant mice) [7].…”
Section: Introductionmentioning
confidence: 99%
“…Two of the transcripts encode the same nuclear protein that binds DNA sequences similar to the Drosophila OVO recognition site [1], whereas the complete sequence of the third and largest transcript remains to be determined. All three Ovol1 transcripts are detected in mouse testis, specifically in premeiotic and meiotic germ cells, and in skin, specifically in differentiating cells of the epidermis and hair follicles [6]. Ablation of Ovol1 in mice leads to male germ cell degeneration and structural abnormalities in the hair shafts, but no obvious defect in the epidermis [6].…”
Section: Introductionmentioning
confidence: 99%
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“…The physical mapping of all genes within this interval will now allow us to understand how closely spaced genes are differentially regulated, and how enhancer activities are insulated from each other. Interestingly, a phenotype resembling aspects of Bardet-Biedl Syndrome was found in mice that carry a targeted disruption of the Ovo1 gene, which encodes a Zinc-finger transcription factor (Dai et al, 1998). Assuming that genes on different Bardet-Biedl loci act in the same developmental and cellular pathways, it is conceivable that genes in the 09/15 synteny region could be regulated by this transcription factor.…”
Section: Resultsmentioning
confidence: 99%