The MMP2 rs243865 polymorphism increases the risk of prostate cancer: A meta-analysis

Abstract

Prostate cancer is a common cancer in men. However, the association between the rs243865 single-nucleotide polymorphisms in the matrix metalloproteinase 2 gene (MMP2) and the risk for prostate cancer is inconclusive. We searched the PubMed, EMBASE, Cochrane Library, and the Chinese CNKI and WANFANG databases for the relevant literature. Data were extracted and pooled results were estimated from odds ratios (OR) with 95% confidence intervals (95% CIs). The quality of included studies was assessed, and publication bias of all included studies was examined. A total five studies involving 1895 patients with prostate cancer and 1918 controls were included. There was a significant association between rs243865 polymorphisms and higher risk of prostate cancer in the co-dominant model, dominant model, and allele model (CC vs. CT+TT, OR: 1.60, 95% CI: 1.22–2.11, P = 0.001; CC vs. CT, OR: 1.80, 95% CI: 1.34–2.42, P < 0.001; C vs. T, OR: 1.32, 95% CI: 1.05–1.66, P = 0.016, respectively). However, there was no significant difference between the co-recessive model and recessive model. Our meta-analysis results suggest that MMP2 rs243865 polymorphisms are significantly associated with higher risk of prostate cancer.

Association between matrix-metalloproteinase polymorphisms and prostate cancer risk: a meta-analysis and systematic review

“… 7 Conversely, both the previous meta-analyses included this study and thus concluded significant association. 17 , 18 For MMP1 rs1799750, our paper enrolled two additional studies 32 , 33 compared with one previous meta-analysis, 17 and obtained a similar result. The major strengths of our paper lie in focusing on the relationship between MMP polymorphisms and prostate cancer risk comprehensively and systematically.…”

“…We noticed two previous meta-analyses had investigated the relationships of MMP1 rs1799750 or MMP2 rs243865 and prostate cancer risk. 17 , 18 We read these carefully with great interest. Neither included other MMP polymorphisms, except for MMP1 rs1799750 and MMP2 rs243865.…”

“…Neither included other MMP polymorphisms, except for MMP1 rs1799750 and MMP2 rs243865. 17 , 18 For MMP2 rs243865, our meta-analysis did not enroll the study by Jacobs et al, because it did not provide available frequency of genotypes. 7 Conversely, both the previous meta-analyses included this study and thus concluded significant association.…”

Correlation of Expression of TGF- β and MMP2 between Prostatic Adenocarcinoma and Adjacent Unaffected Parenchyma

“…In prostate cancer, its overexpression by malignant prostatic epithelium is considered to contribute to increased tumor invasiveness, migration, metastasis, higher tumor stage, higher Gleason score and is related to shorter disease-free survival, but it is also involved in prostate cancer development (4,5,15). It is also believed that MMP2 rs243865 polymorphisms are related to higher risk of prostate adenocarcinoma and metastasis (17). MMP2 and TGFβ are closely related since MMP2 stimulates EMT through the activation of TGFβ by solubilizing TGF-β of extracellular matrix (13).…”

Programmed death-ligand 1 single nucleotide polymorphism affects breast cancer chemosensitivity and adverse events in the neoadjuvant setting

“…Noncoding SNP mutations are often associated with tumor development. [21][22][23][24][25] Currently, studies of SNPs have mainly focused on coding SNPs. The role of noncoding SNPs in disease development remains obscure.…”