The miRNA-608 rs4919510 G>C polymorphism confers reduce coronary injury of Kawasaki disease in a Southern Chinese population

Abstract

Kawasaki disease (KD) is also called mucocutaneous lymph node syndrome and is an acute febrile pediatric disease characterized by systemic vasculitis. KD typically occurs in children 5 years old or younger and occurs more often in males than in females. miRNA-608 has been reported to interact with interleukin-6 and affect innate immunity. The immune-mediated inflammation could induce the occurrence of KD; however, there is no previous research focused on the relationship between miRNA-608 polymorphism and the KD risk. The present study explored the correlation between the miRNA-608 rs4919510 G>C polymorphism and the risk for KD. We recruited 532 patients with KD and 623 controls to genotype the miRNA-608 rs4919510 G>C polymorphism with a TaqMan allelic discrimination assay. Single-locus analysis showed no significant association between miRNA rs4919510 G>C polymorphism and KD susceptibility. However in an analysis stratified by age, gender, and coronary artery lesion (CAL), we found a relationship between the miRNA-608 rs4919510 G>C polymorphism and KD susceptibility. When KD patients were stratified by coronary injury, the CG/CC genotypes of the miRNA-608 rs4919510 G>C polymorphism contributed to a higher occurrence of KD than that was found in the GG genotype patients (adjusted odds ratio = 0.74, 95% CI = 0.56–0.98, P = 0.033). The present study demonstrated that the miRNA-608 rs4919510 G>C polymorphism may have a CAL-related relationship with KD susceptibility that has not been previously revealed.

The PTGS1 (rs1330344) CC Genotype Contributes to Susceptibility to Kawasaki Disease in Southern Chinese Children

“…31,32 We have previously reported that the CG/CC genotypes of the miRNA -608 rs4919510 polymorphism contribute to a higher occurrence of KD than the GG genotype. 33 ATP-binding cassette subfamily C member 4 ( ABCC4 ) rs7986087 T variant genotypes are also significantly associated with increased KD susceptibility, though the rs868853 T variant genotypes are associated with reduced KD susceptibility. 34 The angiotensinogen ( ATG ) polymorphism rs5050 significantly increases the risk of CAA in children with KD.…”

LNC-ZNF33B-2:1 gene rs579501 polymorphism is associated with organ dysfunction and death risk in pediatric sepsis

“…We genotyped SNP (lnc-ZNF33B-2:1 rs579501 was purchased from Applied Biosystems) from genomic DNA isolated from venous whole blood samples of sepsis patients and healthy controls. The DNA extraction and genotyping procedures have been published previously ( Wang et al, 2019 ).…”

Association study of miR‐149, miR‐196a2, and miR‐499a polymorphisms with coronary artery aneurysm of Kawasaki disease in southern Chinese population

“…Our team previously found that the miR‐218 rs11134527 A>G polymorphism was not associated with KD risk, but it may have an age‐related relationship with KD susceptibility 15 . The miR‐608 rs4919510 G>C polymorphism may be a protective factor for coronary artery injury in KD 16 . Compared with carriers of the TT genotype, patients aged under 12 months who carried the miRNA‐13 rs1625579 TG/GG genotype showed a significantly higher risk of developing KD 17 .…”

“… 15 The miR‐608 rs4919510 G>C polymorphism may be a protective factor for coronary artery injury in KD. 16 Compared with carriers of the TT genotype, patients aged under 12 months who carried the miRNA‐13 rs1625579 TG/GG genotype showed a significantly higher risk of developing KD. 17 These results indicate that miRNA polymorphisms may play a key role in the pathogenesis and pathological process of KD.…”