The<i>lin-4</i>microRNA

Esquela-Kerscher, Aurora

doi:10.4161/cc.28384

Cited by 15 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MiR-125b is the human orthologue of lin-4, which is crucial for post-embryonic proliferation and differentiation 25 . Recently, miR-125b has gained special interest in cancer research 31 .…”

Section: Discussionmentioning

confidence: 99%

“…Examples include miR-451/Ankrd46 19 , miR-429/Pcdh820 20 , miR-181/LIF 21 , miR-145/IGF1R 22 , miR-143/Lifr 23 , and let-7/mucin1 24 . MiR-125b is the human orthologue of lin-4, which is essential for embryonic proliferation and differentiation 25 . MiR-125b is expressed at high levels in the ovaries, pituitary gland, uterus and placenta, and has gained special interest in cancer research 26 .…”

mentioning

confidence: 99%

See 1 more Smart Citation

MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day

Chen

Zhao

et al. 2016

Sci Rep

View full text Add to dashboard Cite

On the women undergoing IVF-ET with elevated progesterone on human chorionic gonadotrophin priming, the assisted reproductive technology outcome is poor. But, due to the unknown mechanism of this process, no effective method has been found to overcome this difficulty. Here, we investigated the roles of miR-125b and its target gene, MMP26, in endometrial receptivity (ER) in these women. The expression of miR-125b was significantly up-regulated in EECs in women with elevated progesterone during the window of implantation, and it showed a progesterone-dependent effect in vitro. Similarly, the expression of miR-125b was significantly up-regulated in the preimplantation period, and was down-regulated in the implantation period and the post-implantation period in mouse EECs. In addition, miR-125b showed a greater decrease at implantation sites than it did at interimplantation sites. The luciferase report assay demonstrated that MMP26 is a target gene of miR-125b. And the expression profile of MMP26 showed an inverse relationship with miR-125b in vivo and in vitro. Overexpression of miR-125b in human EECs inhibited cell migration and invasion. Gain-of-function of miR-125b induced a significant decrease in the number of implantation sites. In conclusion, these data shed new light on how miR-125b triggers ER decline through the regulation of MMP26 function.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day

Chen

Zhao

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…MiRNAs are among the majority class of newly identified non-coding small RNAs (~ 20 nucleotides (nt)) that act as negative regulator of gene expression at the post-transcriptional level by targeting messenger RNA (mRNAs) for cleavage or inhibiting the translation process (Ha and Kim 2014;Rogers and Chen 2013;Samad et al 2017a). The first miRNA (lin-4) was discovered by Ambros, and is now recognized as the pioneer of the large miRNA family (Esquela-Kerscher 2014). In a couple of decades, enormous progress has been achieved in this field.…”

Section: Introductionmentioning

confidence: 99%

Deep sequencing and in silico analysis of small RNA library reveals novel miRNA from leaf Persicaria minor transcriptome

et al. 2018

View full text Add to dashboard Cite

In current era, majority of microRNA (miRNA) are being discovered through computational approaches which are more confined towards model plants. Here, for the first time, we have described the identification and characterization of novel miRNA in a non-model plant, (. ) using computational approach. Unannotated sequences from deep sequencing were analyzed based on previous well-established parameters. Around 24 putative novel miRNAs were identified from 6,417,780 reads of the unannotated sequence which represented 11 unique putative miRNA sequences. PsRobot target prediction tool was deployed to identify the target transcripts of putative novel miRNAs. Most of the predicted target transcripts (mRNAs) were known to be involved in plant development and stress responses. Gene ontology showed that majority of the putative novel miRNA targets involved in cellular component (69.07%), followed by molecular function (30.08%) and biological process (0.85%). Out of 11 unique putative miRNAs, 7 miRNAs were validated through semi-quantitative PCR. These novel miRNAs discoveries in. may develop and update the current public miRNA database.

show abstract

“…They found that lin-4 had an essential role in the growth and differentiation of C. elegans hypodermic stem cells. Lin-4 was later found to suppress gene expression of lin-28 and lin-14 by binding to the complementary regions of their 3′ UTRs [ 11 , 12 ]. Although these findings were quite exciting, this phenomenon seemed restricted to nematode development as there were no homologs found in vertebrates until a few years later with the discovery of a second miRNA, let-7 [ 13 , 14 ].…”

Section: Discovery Of Mirnasmentioning

confidence: 99%

The Role of miRNAs, miRNA Clusters, and isomiRs in Development of Cancer Stem Cell Populations in Colorectal Cancer

Stark

Facey²,

Viswanathan

et al. 2021

IJMS

View full text Add to dashboard Cite

MicroRNAs (miRNAs or miRs) have a critical role in regulating stem cells (SCs) during development and altered expression can cause developmental defects and/or disease. Indeed, aberrant miRNA expression leads to wide-spread transcriptional dysregulation which has been linked to many cancers. Mounting evidence also indicates a role for miRNAs in the development of the cancer SC (CSC) phenotype. Our goal herein is to provide a review of: (i) current research on miRNAs and their targets in colorectal cancer (CRC), and (ii) miRNAs that are differentially expressed in colon CSCs. MicroRNAs can work in clusters or alone when targeting different SC genes to influence CSC phenotype. Accordingly, we discuss the specific miRNA cluster classifications and isomiRs that are predicted to target the ALDH1, CD166, BMI1, LRIG1, and LGR5 SC genes. miR-23b and miR-92A are of particular interest because our previously reported studies on miRNA expression in isolated normal versus malignant human colonic SCs showed that miR-23b and miR-92a are regulators of the LGR5 and LRIG1 SC genes, respectively. We also identify additional miRNAs whose expression inversely correlated with mRNA levels of their target genes and associated with CRC patient survival. Altogether, our deliberation on miRNAs, their clusters, and isomiRs in regulation of SC genes could provide insight into how dysregulation of miRNAs leads to the emergence of different CSC populations and SC overpopulation in CRC.

show abstract

Thelin-4microRNA

Cited by 15 publications

References 8 publications

MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day

MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day

Deep sequencing and in silico analysis of small RNA library reveals novel miRNA from leaf Persicaria minor transcriptome

The Role of miRNAs, miRNA Clusters, and isomiRs in Development of Cancer Stem Cell Populations in Colorectal Cancer

Contact Info

Product

Resources

About