The kdr mutation occurs in the Mopti form of Anopheles gambiaes.s. through introgression

Weill, Mylène; Chandre, Fabrice; Brengues, C.; Manguin, Sylvie; Akogbéto, Martin; Pasteur, Nicole; Guillet, Pierre; Raymond, Michel

doi:10.1046/j.1365-2583.2000.00206.x

Cited by 170 publications

(197 citation statements)

References 13 publications

(24 reference statements)

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“…17,19 However, in southern Benin, the kdr mutation was recently detected in the M population. 20,21 The low genetic diversity in the sodium channel introns of the resistant M and S mosquitoes suggests that a genetic sweep has occurred through an introgression from the S form. 21 On the basis of this resistance survey in 2000, resistance is absent in An.…”

Section: Discussionmentioning

confidence: 99%

The role of agricultural use of insecticides in resistance to pyrethroids in Anopheles gambiae s.l. in Burkina Faso.

Diabaté¹,

Baldet²,

Chandre³

et al. 2002

The American Journal of Tropical Medicine and Hygiene

420

383

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Abstract. Agricultural use of insecticides is involved in the selection of resistance to these compounds in field populations of mosquitoes in Burkina Faso. Anopheles gambiae s.l. was resistant to permethrin and DDT in cottongrowing and urban areas, but susceptible in areas with limited insecticide selection pressure (rice fields and control areas). Nevertheless, resistance to these insecticides was observed in a village on the outskirts of the rice fields at the end of the rainy season, suggesting that the latter population of mosquitoes had migrated from the surrounding cotton villages into the rice fields. A seasonal variation of resistance observed in the cotton-growing area is related to the distribution of the molecular M and S forms of An. gambiae, since resistance to pyrethroids has so far only been reported in the S form. Pyrethroid resistance in west African An. gambiae was conferred by target site insensitivity through a knockdown resistance (kdr)-like mutation, which was present at high frequencies in mosquitoes in the cotton-growing and urban areas.

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Section: Discussionmentioning

confidence: 99%

The role of agricultural use of insecticides in resistance to pyrethroids in Anopheles gambiae s.l. in Burkina Faso.

Diabaté¹,

Baldet²,

Chandre³

et al. 2002

The American Journal of Tropical Medicine and Hygiene

420

383

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“…The first report of L1014F in A. coluzzii came in 2000 from samples collected in southern Benin. Based on intron sequencing, L1014F was thought to have emerged in A. coluzzii via introgression from sympatric A. gambiae (12). A recent detailed genome sequencing study clearly described how the L1014F mutation and the entire 2L island of divergence has introgressed from A. gambiae into A. coluzzii in southern Ghana.…”

Section: Significancementioning

confidence: 99%

“…The knockdown resistance SNP, L1014F (11), in the para voltage-gated sodium channel gene (kdr) is located ∼2.4 Mbp from the 2L centromere and within the introgressed region identified by Lee et al (5). The L1014F SNP is thought to have arisen in West African A. gambiae populations (12) and confers target site resistance to dichlorodiphenyltrichloroethane (DDT) and pyrethroid insecticides (11,13). Recent and intense pyrethroid-based control programs are thought to have strongly selected for L1014F in A. gambiae (14,15).…”

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confidence: 99%

Adaptive introgression in an African malaria mosquito coincident with the increased usage of insecticide-treated bed nets

Norris

Main

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

203

258

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Animal species adapt to changes in their environment, including man-made changes such as the introduction of insecticides, through selection for advantageous genes already present in populations or newly arisen through mutation. A possible alternative mechanism is the acquisition of adaptive genes from related species via a process known as adaptive introgression. Differing levels of insecticide resistance between two African malaria vectors, Anopheles coluzzii and Anopheles gambiae, have been attributed to assortative mating between the two species. In a previous study, we reported two bouts of hybridization observed in the town of Selinkenyi, Mali in 2002 and 2006. These hybridization events did not appear to be directly associated with insecticide-resistance genes. We demonstrate that during a brief breakdown in assortative mating in 2006, A. coluzzii inherited the entire A. gambiae-associated 2L divergence island, which includes a suite of insecticide-resistance alleles. In this case, introgression was coincident with the start of a major insecticide-treated bed net distribution campaign in Mali. This suggests that insecticide exposure altered the fitness landscape, favoring the survival of A. coluzzii/A. gambiae hybrids, and provided selection pressure that swept the 2L divergence island through A. coluzzii populations in Mali. We propose that the work described herein presents a unique description of the temporal dynamics of adaptive introgression in an animal species and represents a mechanism for the rapid evolution of insecticide resistance in this important vector of human malaria in Africa.

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“…In general, in West African countries, apart from Benin, the kdr resistance locus is at or near fixation in the S-form populations but occurs in the M form at very low levels, even in sympatry (della Torre et al 2001;Yawson et al 2004). Importantly, it has been proposed that the kdr mutation may have introgressed from the S form into the M form (Weill et al 2000), raising the possibility that there could be numerous adaptively and epidemiologically important genetic exchanges between forms.…”

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confidence: 99%

Ecological Zones Rather Than Molecular Forms Predict Genetic Differentiation in the Malaria VectorAnopheles gambiaes.s. in Ghana

et al. 2007

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The malaria mosquito Anopheles gambiae s.s. is rapidly becoming a model for studies on the evolution of reproductive isolation. Debate has centered on the taxonomic status of two forms (denoted M and S) within the nominal taxon identified by point mutations in the X-linked rDNA region. Evidence is accumulating that there are significant barriers to gene flow between these forms, but that the barriers are not complete throughout the entire range of their distribution. We sampled populations from across Ghana and southern Burkina Faso, West Africa, from areas where the molecular forms occurred in both sympatry and allopatry. Neither Bayesian clustering methods nor F ST -based analysis of microsatellite data found differentiation between the M and S molecular forms, but revealed strong differentiation among different ecological zones, irrespective of M/S status and with no detectable effect of geographical distance. Although no M/S hybrids were found in the samples, admixture analysis detected evidence of contemporary interform gene flow, arguably most pronounced in southern Ghana where forms occur sympatrically. Thus, in the sampled area of West Africa, lack of differentiation between M and S forms likely reflects substantial introgression, and ecological barriers appear to be of greater importance in restricting gene flow.

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The kdr mutation occurs in the Mopti form of Anopheles gambiaes.s. through introgression

Cited by 170 publications

References 13 publications

The role of agricultural use of insecticides in resistance to pyrethroids in Anopheles gambiae s.l. in Burkina Faso.

The role of agricultural use of insecticides in resistance to pyrethroids in Anopheles gambiae s.l. in Burkina Faso.

Adaptive introgression in an African malaria mosquito coincident with the increased usage of insecticide-treated bed nets

Ecological Zones Rather Than Molecular Forms Predict Genetic Differentiation in the Malaria VectorAnopheles gambiaes.s. in Ghana

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