Thein vivoandin vitrotransmission ratio distortion of one complete and two partialthaplotypes in mice

Work on the genetic region of the house mice known as the t‐complex has produced the hypothesis that mice heterozygous for t‐haplotypes (+/t) may have a selective advantage over wild‐type (+/+) males owing to the greater aggressiveness of +/t males. We tested this hypothesis by examining the behavior of +/+ and +/t mice placed in four large outdoor enclosures. We found that +/t males were dominant over +/+ males. Furthermore, in the outdoor enclosures +/t males had higher survivorship than +/+ males, both as adults and juveniles. However, males of the two genotypes did not differ in home range size. We suggest that t‐haplotypes may be, in part, maintained in mouse populations because of a selective advantage in heterozygous males. © 1996 Wiley‐Liss, Inc.

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Genetic basis for male aggression and survivorship in wild house mice (Mus domesticus)

Lenington

Drickamer

Robinson

et al. 1996

Aggr. Behav.

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Low Frequency of Mouse t Haplotypes in Wild Populations Is Not Explained by Modifiers of Meiotic Drive

Ardlie

Silver

1996

Genetics

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t haplotypes are naturally occurring forms of mouse chromosome 17 that show non-Mendelian transmission from heterozygous +/t males. In laboratory studies, transmission ratios of ≥0.90 or higher are typically observed. With transmission ratios of this level, theoretical analyses predict high frequencies of t haplotypes (∼75%) in wild populations. In contrast, empirical frequencies of only 15–25% are typically found. This has led to the suggestion that modifiers of drive may play a role in reducing t frequencies. We have measured transmission ratio distortion (TRD) levels in wild +/t mice to examine this hypothesis. TRD was very high in both litters collected from wild-caught pregnant females, and in wild litters bred in the laboratory (mean = 0.9). Contrary to the results of other studies, we found no difference in TRD levels between semilethal and lethal t haplotypes nor between litters conceived from cycling or postpartum estrus. We found three litters with aberrantly low TRDs that were all multiply sired, although the role this might play in natural populations is unknown. These findings show a general absence of modifiers of drive in natural populations and suggest that other factors are responsible for the low observed frequencies of wild t haplotypes.

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Models for male infertility: the t haplotypes

Olds‐Clarke

1997

Reviews of Reproduction

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The t haplotypes are variant alleles of genes in the proximal region of mouse Chromosome 17, linked together by four inversions. While females carrying two t haplotypes are fertile, males are sterile. Their spermatozoa exhibit severe motility defects and are unable to penetrate zona pellucida-free oocytes. Spermatozoa from males carrying one t haplotype (t/+) exhibit mild motility deficits and a delay in penetration of the zona-free oocyte. The inversions of the t haplotypes contain several genes that cause or contribute to male sterility, at least some of which can be identified by analysis of mice carrying Mus spretus-Mus domesticus recombinant Chromosomes 17. The t haplotypes specify a number of sperm biochemical abnormalities, but these have not been related directly to defects in fertilization. In t/+ males, spermatozoa not bearing the t haplotype are defective in fertilization compared with t-bearing spermatozoa. The mechanism causing this is likely to involve haploid gene expression confined to the t-bearing spermatids. Since many genes situated in the region of the t haplotypes have human homologues, an understanding of t haplotype sterility in mice is expected to contribute significantly to our knowledge of the genetic basis for human sperm dysfunction.

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Thein vivoandin vitrotransmission ratio distortion of one complete and two partialthaplotypes in mice

Cited by 3 publications

References 23 publications

Genetic basis for male aggression and survivorship in wild house mice (Mus domesticus)

Genetic basis for male aggression and survivorship in wild house mice (Mus domesticus)

Low Frequency of Mouse t Haplotypes in Wild Populations Is Not Explained by Modifiers of Meiotic Drive

Models for male infertility: the t haplotypes

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