THE<i>IN VITRO</i>EFFECTS OF ARTIFICIAL AND NATURAL SWEETENERS ON THE IMMUNE SYSTEM USING WHOLE BLOOD CULTURE ASSAYS

Rahiman, Farzana; Pool, Edmund John

doi:10.1080/15321819.2013.784197

Cited by 25 publications

(24 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However this evidence is only epidemiologic correlation and animal modeling, and lacks direct human investigation. Other studies looking at the effects of sweeteners in cell culture suggest anti-inflammatory effects in the blood [36,37]. Few studies on newer sweeteners have been conducted, yet limited cell-culture evidence on stevioside suggests anti-inflammatory properties while improving phagocytosis and mitogen responses for both T and B cells [38-40].…”

Section: Introductionmentioning

confidence: 99%

Fast food fever: reviewing the impacts of the Western diet on immunity

Myles

2014

Nutr J

320

172

View full text Add to dashboard Cite

While numerous changes in human lifestyle constitute modern life, our diet has been gaining attention as a potential contributor to the increase in immune-mediated diseases. The Western diet is characterized by an over consumption and reduced variety of refined sugars, salt, and saturated fat. Herein our objective is to detail the mechanisms for the Western diet’s impact on immune function. The manuscript reviews the impacts and mechanisms of harm for our over-indulgence in sugar, salt, and fat, as well as the data outlining the impacts of artificial sweeteners, gluten, and genetically modified foods; attention is given to revealing where the literature on the immune impacts of macronutrients is limited to either animal or in vitro models versus where human trials exist. Detailed attention is given to the dietary impact on the gut microbiome and the mechanisms by which our poor dietary choices are encoded into our gut, our genes, and are passed to our offspring. While today’s modern diet may provide beneficial protection from micro- and macronutrient deficiencies, our over abundance of calories and the macronutrients that compose our diet may all lead to increased inflammation, reduced control of infection, increased rates of cancer, and increased risk for allergic and auto-inflammatory disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Fast food fever: reviewing the impacts of the Western diet on immunity

Myles

2014

Nutr J

320

172

View full text Add to dashboard Cite

show abstract

“…Treatment with 10 µg/mL aspartame was reported to inhibited lipopolysaccharides-stimulated IL-6 whereas production of IL-10 was slightly increased in human whole blood cultures (Rahiman and Pool, 2014). Aspartame interference with the formation of complexes between normal human IgG Fc and IgM-type rheumatoid factor was © 2015 The Society for Investigative Dermatology 10 described (Ramsland et al, 1999).…”

Section: Discussionmentioning

confidence: 97%

“…These functions include increased motor activity and attenuated mechanical hyperalgesia in a carrageenan-elicited monoarthritis murine model (LaBuda and Fuchs, 2001). Aspartame also reportedly reduces lipopolysaccharide-stimulated interleukin (IL)-6, which is a recognized biomarker of the inflammatory response, and slightly increases the anti-inflammatory cytokine, IL-10, in human whole blood cultures (Rahiman and Pool, 2014). Although there is no direct evidence for the anti-inflammatory functions of aspartame, it may involve the inhibition of prostaglandin (PG) H 2 synthesis and cyclooxygenases (COXs).…”

Section: Introductionmentioning

confidence: 96%

“…Computer-assisted virtual modeling has shown that aspartame is a suitable ligand for human Bence-Jones dimer, which represents an immunoglobulin light chain (Edmundson and Manion, 1998). The aspartame and the dimer has been closely matched to the active site of the COX portion of PG H 2 synthase-1 and interaction with immunoglobulin M rheumatoid factors (Edmundson and Manion, 1998;Rahiman and Pool, 2014). In patients with osteoarthritis, treatment with aspartame increased bleeding time, relieves pain, and improves performance including walking, climbing, and grip strength (Edmundson and Manion, 1998).…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Aspartame Attenuates 2, 4-Dinitrofluorobenzene-Induced Atopic Dermatitis–Like Clinical Symptoms in NC/Nga Mice

Kim

Park

Ahn

et al. 2015

Journal of Investigative Dermatology

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a common multifactorial chronic skin disease that has a multiple and complex pathogenesis. AD is gradually increasing in prevalence globally. In NC/Nga mice, repetitive applications of 2, 4-dinitrofluorobenzene (DNFB) evoke AD-like clinical symptoms similar to human AD. Aspartame (N-L-α-aspartyl-L-phenylalanine 1-methyl ester) is a methyl ester of a dipeptide, which is used as an artificial non-nutritive sweetener. Aspartame has analgesic and anti-inflammatory functions that are similar to the function of nonsteroidal anti-inflammatory drugs such as aspirin. We investigated whether aspartame can relieve AD-like clinical symptoms induced by DNFB treatment in NC/Nga mice. Sucrose did not relieve AD-like symptoms, whereas aspartame at doses of 0.5 μg kg(-1) and 0.5 mg kg(-1) inhibited ear swelling and relieved AD-like clinical symptoms. Aspartame inhibited infiltration of inflammatory cells including eosinophils, mast cells, and CD4(+) T cells, and suppressed the expression of cytokines including IL-4 and IFN-γ, and total serum IgE levels. Aspartame may have therapeutic value in the treatment of AD.

show abstract

“…Sucrose intake is related to increased concentrations of inflammatory markers such as haptoglobin, transferrin and C-reactive protein [17]. Sucralose suppresses the secretion of interleukin (IL)-6 and IL-10 [18] and modifies the composition of the intestinal microbiota and other immune pathologies [5]. The immunomodulatory activity of stevia is attributed to the stimulation of cellular and humoral immunity, and B and T cell proliferation [19].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Prolonged Sweetener Consumption and Chronic Stress in the Production of Carbonylated Proteins in Blood Lymphocytes

García-Iniesta

Martínez-Carrillo

Valdés‐Ramos

et al. 2017

EJNFS

View full text Add to dashboard Cite

Introduction: Modern lifestyles have changed eating habits, encouraged physical inactivity, and increased stress in daily life. These living conditions cause elevated concentrations of carbonylated proteins like biomarker of oxidative stress. The expression of this proteins represent irreversible damage to structural intracellular proteins in cells and extracellular matrix. It is not clear whether a rise in the concentration of these proteins is the origin or consequence of diseases. Objective: To determine in a healthy young mice model the possible correlation between prolonged sweetener consumption and the presence of chronic physiological stress, evidenced by the production of carbonylated proteins in peripheral blood lymphocytes. Methods: Sixty-four 21-day-old CD1 male mice were divided into two groups, stressed (with immobilization) and unstressed. Each group was divided into four subgroups: Control or experimental with a 6-week administration of sucrose, sucralose or stevia. Body mass index, food intake, number and concentration of carbonylated proteins, levels of glucose and peripheral lymphocytes in blood were evaluated. Data were analyzed with ANOVA. Results: Compared to the unstressed control, the glucose concentration was elevated in all

show abstract

THEIN VITROEFFECTS OF ARTIFICIAL AND NATURAL SWEETENERS ON THE IMMUNE SYSTEM USING WHOLE BLOOD CULTURE ASSAYS

Cited by 25 publications

References 23 publications

Fast food fever: reviewing the impacts of the Western diet on immunity

Fast food fever: reviewing the impacts of the Western diet on immunity

Aspartame Attenuates 2, 4-Dinitrofluorobenzene-Induced Atopic Dermatitis–Like Clinical Symptoms in NC/Nga Mice

Relationship between Prolonged Sweetener Consumption and Chronic Stress in the Production of Carbonylated Proteins in Blood Lymphocytes

Contact Info

Product

Resources

About