The <i>in situ</i> synthesis of Ag/amino acid biopolymer hydrogels as mouldable wound dressings

Zhang, Zhenzhu; He, Ting; Yuan, Mengying; Shen, Rujuan; Liu, Deng; Yi, Lunzhao; Sun, Zhifang; Zhang, Yi

doi:10.1039/c5cc05195a

Cited by 56 publications

(48 citation statements)

References 44 publications

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“…Metal cations can be adsorbed by chelation on amino groups of CS due to the free electron doublet on nitrogen, and hydroxyl groups (especially in the C-3 position) may also contribute to sorption28. While most researchers focused directly on the applications of complexes between CS and metal ions, like decontamination of effluents29, catalysis industry30, advanced composite soft materials3132, and noble metals reclamation33, few attention was paid on the design of novel hydrogel materials with hierarchical structure taking advantage of the complexes. In addition to the interaction of metal ions and CS on molecular level, it has been reported that the introduction of metal ions can influence the structure of in-situ prepared CS hydrogel3435.…”

mentioning

confidence: 99%

Chitosan Hydrogel Structure Modulated by Metal Ions

Nie

Wang

2016

Sci Rep

101

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As one of the most important polysaccharide, chitosan (CS) has generated a great deal of interest for its desirable properties and wide applications. In the utilization of CS materials, hydrogel is a major and vital branch. CS has the ability to coordinate with many metal ions by a chelation mechanism. While most researchers focused on the applications of complexes between CS and metal ions, the complexes can also influence gelation process and structure of CS hydrogel. In the present work, such influence was studied with different metal ions, revealing two different kinds of mechanisms. Strong affinity between CS and metal ions leads to structural transition from orientation to multi-layers, while weak affinity leads to composite gel with in-situ formed inorganic particles. The study gave a better understanding of the gelation mechanism and provided strategies for the modulation of hydrogel morphology, which benefited the design of new CS-based materials with hierarchical structure and facilitated the utilization of polysaccharide resources.

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confidence: 99%

Chitosan Hydrogel Structure Modulated by Metal Ions

Nie

Wang

2016

Sci Rep

101

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“…Metallogels, especially metallohydrogels containing Au nanoparticles (AuNPs) and Ag nanoparticles (AgNPs) are wildly applied in biological applications such as antibacterial materials, anticancer therapy, cell culture, and tissue repairing . Due to their localized surface plasmon resonance (LSPR), noble‐metal nanoparticles absorb light at certain wavelengths and they have enhanced absorption ratio in comparing with conventional photoabsorbing dyes .…”

Section: Fundamental Applications Of Metallogelsmentioning

confidence: 99%

“…Fmoc‐Val‐Asp‐OH and Fmoc‐ l ‐phenylalanine formed AgNP gels after exposure to sunlight. Zhang et al also demonstrated the ability of natural materials to act as a matrix to bear the sunlight‐reduced AgNPs.…”

Section: Fundamental Applications Of Metallogelsmentioning

confidence: 99%

“…Incorporation of metal components (metal ions, metal–organic molecules, and metal nanoparticles) is an effective way to locally establish extra interactions among the building blocks and consequently trigger gel formation, weaken or enhance gel strength, and modify gel morphology . Moreover, addition of metal components is a straightforward way to integrate the specific properties of metals with the properties of organic matrix, therefore to tune properties like conductivity, color, rheological behavior, adsorption, emission, photophysical properties, magnetism, antibacterial activities, catalytic activities, redox activities, and self‐healing properties . Therefore, a broad response range to physical and chemical stimuli can be achieved.…”

Section: Introductionmentioning

confidence: 99%

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Metallogels: Availability, Applicability, and Advanceability

et al. 2019

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amount of cross-linked solid. According to the nature of solvents, gels are categorized into hydrogel and organogel to indicate whether the solvent is water or organic solvent(s), respectively. As to the gelation driving forces, gels can be classified into physical gels in which intermolecular interactions are responsible for gel formation, and chemical gels in which the gel skeleton is cross-linked by covalent bonds.Incorporation of metal components (metal ions, metal-organic molecules, and metal nanoparticles) is an effective way to locally establish extra interactions among the building blocks and consequently trigger gel formation, [2][3][4] weaken [5] or enhance [6] gel strength, and modify gel morphology. [7,8] Moreover, addition of metal components is a straightforward way to integrate the specific properties of metals with the properties of organic matrix, therefore to tune properties like conductivity, [9] color, [10,11] rheological behavior, [12] adsorption, [13] emission, [14] photophysical properties, [15] magnetism, [16,17] antibacterial activities, [18,19] catalytic activities, [20][21][22][23] redox activities, [24,25] and selfhealing properties. [26][27][28] Therefore, a broad response range to physical and chemical stimuli can be achieved. For instance, the incorporation of multivalence ions such as Fe 2+ /Fe 3+ , [25,29] Co 2+ / Co 3+ , [30] Cu + /Cu 2+ , [31] results in redox reactive hydrogels; the incorporation of magnetic nanoparticles like Fe 3 O 4[17] causes the gel to respond to external magnetic fields. In addition to the abovementioned intrinsically functional superiorities, metallogels can also serve as ideal templates to generate new materials, [13,22,23,32,33] such as 3D networks, [34] porous structures, [35] chiral materials, [36][37][38] quantum dots, [39] and nanorods. [40] Following the rapid advancement of exploration on the knowledge acquisition toward the major roles that metallogels are playing in catalysis, sensing, biomedicine, electronics, and optical devices, the focus of research has been transferred to the design principles of metallogels in the last decade. Owing to the advancements in the instrumental characterizations and theoretical calculations, [41] a number of pioneering efforts on metallogel design have been made and several innovative reviews have summarized these inspiring contributions. [32,[42][43][44] Despite their extensively acknowledged application advantages in many fields, the discovery of new metallogels with expected functionalities is still highly dependent on experimental screening and serendipity. The challenge stems from the susceptible balance among those complicated intermolecular interactions and the elaborate structure requirements of metallogels.Another research niche that needs to be clarified before discussing recent development of metallogels is: how to sort Introducing metal components into gel matrices provides an effective strategy to develop soft materials with advantageous properties such as: optical activity, conductivity, magn...

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“…Incorporation of AgNPs into hydrogels can endow hydrogels with enhanced performance and new properties20. Furthermore, the three-dimensional hydrogel networks can facilitate the dispersion and stabilization of AgNPs2122. Abdel-Halim and his coworker adopted guar gum together with poly(acrylic acid) to prepare hydrogels which were used as a matrix for AgNPs23.…”

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confidence: 99%

Silver nanoparticles-containing dual-function hydrogels based on a guar gum-sodium borohydride system

Dai

Nadeau

et al. 2016

Sci Rep

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Dual-function hydrogels, possessing both stimuli-responsive and self-healing properties, have recently attracted attention of both chemists and materials scientists. Here we report a new paradigm using natural polymer (guar gum, GG) and sodium borohydride (NaBH4), for the preparation of silver nanoparticles (AgNPs)-containing smart hydrogels in a simple, fast and economical way. NaBH4 performs as a reducing agent for AgNPs synthesis using silver nitrate (AgNO3) as the precursor. Meanwhile, sodium metaborate (NaBO2) (from NaBH4) behaves as a cross-linking agent between GG molecular chains. The AgNPs/GG hydrogels with excellent viscoelastic properties can be obtained within 3 min at room temperature without the addition of other cross-linkers. The resultant AgNPs/GG hydrogels are flowable and injectable, and they possess excellent pH/thermal responsive properties. Additionally, they exhibit rapid self-healing capacity. This work introduces a facile and scale-up way to prepare a class of hydrogels that can have great potential to biomedical and other industrial applications.

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The in situ synthesis of Ag/amino acid biopolymer hydrogels as mouldable wound dressings

Cited by 56 publications

References 44 publications

Chitosan Hydrogel Structure Modulated by Metal Ions

Chitosan Hydrogel Structure Modulated by Metal Ions

Metallogels: Availability, Applicability, and Advanceability

Silver nanoparticles-containing dual-function hydrogels based on a guar gum-sodium borohydride system

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