The <i>GNAS1</i> T393C Polymorphism Predicts Survival in Patients With Advanced Squamous Cell Carcinoma of the Larynx

Lehnerdt, Goetz; Franz, Peter; Winterhoff, Sebastian; Bànkfalvi, Àgnes; Grehl, Sara; Lang, Stephan; Schmid, Kurt Werner; Siffert, Winfried; Jahnke, K.; Frey, Ulrich H.

doi:10.1097/mlg.0b013e318185793ds

Cited by 18 publications

(10 citation statements)

References 23 publications

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“…Gastric cancer is the fourth most common cancer with [15] 2008 157 Survival was significantly dependent on the T393C genotype in advanced American Joint Committee on Cancer (AJCC) stages (Ⅲ-Ⅳ) with higher 5-yr survival rates for TT, followed by TC and CC (P = 0.0437)…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies indicate that increased expression of Gαs enhances apoptosis [7,8] and that Gαs mRNA expression is different between T393C genotypes [9] . For various solid tumors, previous studies demonstrated that patient survival and tumor progression depended on T393C genotype [10][11][12][13][14][15][16][17] . Until now, nothing has been published about the impact of the GNAS1 T393C polymorphism on gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

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Association of the GNAS1 T393C polymorphism with tumorstage and survival in gastric cancer

Alakus¹,

Mönig²,

Warnecke-Eberz³

et al. 2009

WJG

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AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer. METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals. Allelic discrimination was performed by quantitative real-time polymerase chain reaction. Genotyping was correlated with histopathologic parameters and with overall survival according to the KaplanMeier approach and with multivariate analysis by multiple stepwise regression. RESULTS:Thirty-nine (32%) patients displayed a CC genotype, 57 (46.7%) a CT genotype and 26 (21.3%) a TT genotype. The frequency of the C allele (fC) in the patient group was 0.55, which was not significantly different from that of healthy blood donors. The distribution was compatible with the Hardy-Weinberg equilibrium. Analysis of clinicopathological parameters did not show any significant correlation of the T393C genotype with gender (P = 0.50), differentiation (P = 0.29), pT-category (P = 0.19), pN-category (P = 0.30), pMcategory (P = 0.25), R-category (P = 0.95), the classifications according to WHO (P = 0.34), Laurén (P = 0.16), Goseki (P = 1.00) and Ming (P = 0.74). Dichotomization between C+ (CC+CT) and C-genotypes (TT), however, revealed significantly more advanced tumor stages (P = 0.023) and lower survival rates (P = 0.043) for C allele carriers. CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of the GNAS1 T393C polymorphism with tumorstage and survival in gastric cancer

Alakus¹,

Mönig²,

Warnecke-Eberz³

et al. 2009

WJG

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“…There is increasing evidence that a common synonymous single nucleotide polymorphism (SNP) in exon 5 (T393C) of the GNAS1 gene is associated with the prognosis of human malignancies [3][4][5][6][7]. Frey et al [8] have showed the genotypes of the GNAS1 T393C polymorphism are associated with altered G s expression.…”

Section: Introductionmentioning

confidence: 98%

“…The Gs protein subunit (GNAS1) gene has been found to play an important role in promoting tumor cells apoptosis [3]. There is increasing evidence that a common synonymous single nucleotide polymorphism (SNP) in exon 5 (T393C) of the GNAS1 gene is associated with the prognosis of human malignancies [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The T393C polymorphism of GNAS1 as a predictor for chemotherapy sensitivity and survival in advanced non-small-cell lung cancer patients treated with gemcitabine plus platinum

Xie

Zhao

Kou

et al. 2012

Cancer Chemother Pharmacol

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“…Hypertension (Jeunemaitre et al 1992) and CAD severity Tumor development and prognosis in several types of tumours (Alakus et al 2009;Lehnerdt et al 2008;Frey et al 2005aFrey et al , b, 2006 0 = TT, 1 = CT, 2 = CC…”

Section: Methodsmentioning

confidence: 99%

Are centenarians genetically predisposed to lower disease risk?

Ruiz

Fiuza‐Luces

Buxens³

et al. 2011

AGE

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Our study purpose was to compare a disease-related polygenic profile that combined a total of 62 genetic variants among (i) people reaching exceptional longevity, i.e., centenarians (n=54, 100-108 years, 48 women) and (ii) ethnically matched healthy controls (n=87, 19-43 years, 47 women). We computed a 'global' genotype score (GS) for 62 genetic variants (mutations/polymorphisms) related to cardiometabolic diseases, cancer or exceptional longevity, and also specific GS for main disease categories (cardiometabolic risk and cancer risk, including 36 and 24 genetic variations, respectively) and for exceptional longevity (7 genetic variants). The 'global' GS was similar among groups (centenarians: 31.0±0.6; controls 32.0±0.5, P=0.263). We observed that the GS for hypertension, cancer (global risk), and other types of cancer was lower in the centenarians group compared with the control group (all P<0.05), yet the difference became non significant after adjusting for sex. We observed significant between-group AGE (2012) 810-13.839), whereas the likelihood of having the GSTMI low-risk (functional) allele was similar in both groups (OR 1.295; 95% CI, 0.868 -1.931). In conclusion, we found preliminary evidence that Spanish centenarians have a lower genetic predisposition for cancer risk. The wild-type (i.e., functional) genotype of GSTT1, which is associated with lower cancer risk, might be associated with exceptional longevity, yet further studies with larger sample sizes must confirm these findings.

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The GNAS1 T393C Polymorphism Predicts Survival in Patients With Advanced Squamous Cell Carcinoma of the Larynx

Abstract: The T393C SNP is a prognostic marker that could help to identify high risk patients suffering from head and neck cancer.

Cited by 18 publications

References 23 publications

Association of the GNAS1 T393C polymorphism with tumorstage and survival in gastric cancer

Association of the GNAS1 T393C polymorphism with tumorstage and survival in gastric cancer

The T393C polymorphism of GNAS1 as a predictor for chemotherapy sensitivity and survival in advanced non-small-cell lung cancer patients treated with gemcitabine plus platinum

Are centenarians genetically predisposed to lower disease risk?

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