TheEscherichia coliTolC efflux pump protein is immunogenic and elicits protective antibodies
TO Silva,
LVS Costa,
L Chagas do Nascimento
et al.
Abstract:Antimicrobial resistance is an increasing worldwide public health burden that threatens to make the existent antimicrobials obsolete. Among the mechanisms of antimicrobial resistance is the overexpression of efflux pumps, such as the AcrA–AcrB–TolC which extrude diverse compounds, reducing the intracellular concentration of antimicrobials. TolC is the outer membrane protein of this pump and has recently gained attention as a therapeutic target. However, little is known about the immune response generated again… Show more
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