The Arabidopsis immune receptor EFR increases resistance to the bacterial pathogens Xanthomonas and Xylella in transgenic sweet orange

Mitre, Letícia Kuster; Teixeira-Silva, Natália Sousa; Rybak, Katarzyna; Magalhães, Diogo Maciel; Souza-Neto, Reinaldo Rodrigues de; Robatzek, Silke; Zipfel, Cyril; Souza, Alessandra Alves de

doi:10.1111/pbi.13629

Cited by 32 publications

(22 citation statements)

References 11 publications

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“…This first breakthrough was followed by numerous studies based on the transfer of PRRs between plant species. Thus, EFR can confer resistance to P. syringae, R. solanacearum and/or Xanthomonas species in tomato, potato, rice, wheat, Medicago, and sweet orange and could even protect apple rootstock from the fire blight caused by E. amylovora (Lacombe et al 2010;Lu et al 2015;Schoonbeek et al 2015;Schwessinger et al 2015;Boschi et al 2017;Pfeilmeier et al 2019;Mitre et al 2021;Piazza et al 2021). Of note, the constitutive expression of EFR in the transgenic plants did not alter growth nor the associated microbiome and did not cause yield penalties (Pfeilmeier et al 2019;Piazza et al 2021).…”

Section: Arabidopsis Efr Confers Resistance To Multiple Bacterial Pat...mentioning

confidence: 98%

Tackling multiple bacterial diseases of Solanaceae with a handful of immune receptors

Kim

Choi

Segonzac

2022

Hortic. Environ. Biotechnol.

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Every year, despite the use of chemicals, significant crop loss is caused by pathogenic microbes. Plant innate resistance to pathogens depends on two sets of genetically encoded immune receptors that sense invaders and trigger signaling cascades leading to reinforcement of physical barriers and production of various antimicrobial compounds. In the past 30 years, the molecular cloning and characterization of plant immune receptors have deepened our understanding of the plant immune system and more importantly, have provided means to improve crop protection against devastating pathogens. Here, we review the molecular characterization of selected immune receptors that can detect multiple species of bacterial pathogens through an expanded recognition range, or through the detection of conserved pathogen activities or host targets. These recent structural and molecular insights about the activation of immune receptors provide the necessary framework to design their concomitant deployment in crops, in order to lower selective pressure on pathogen populations and prevent evasion from recognition. Hence, these few immune receptors emerge as high potential genetic resources to provide durable and environmentally safe protection against important bacterial diseases of solanaceous crops.

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Section: Arabidopsis Efr Confers Resistance To Multiple Bacterial Pat...mentioning

confidence: 98%

Tackling multiple bacterial diseases of Solanaceae with a handful of immune receptors

Kim

Choi

Segonzac

2022

Hortic. Environ. Biotechnol.

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“…citri ( Xcc ) and Xylella fastidiosa subsp. pauca ( Xfp ), respectively (Mitre et al ., 2021 ; Pfeilmeier et al ., 2019 ). Notably, interspecies transfer of AtEFR into apple ( Malus domestica ) significantly reduced the extent of tissue necrosis associated with Erwinia amylovora infection, which causes fire blight disease (Piazza et al ., 2021 ).…”

Section: Engineering Pti Receptors To Confer Broad...mentioning

confidence: 99%

Engineering plant immune circuit: walking to the bright future with a novel toolbox

Vuong

Iswanto

Nguyen

et al. 2022

Plant Biotechnology Journal

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Plant pathogens destroy crops and cause severe yield losses, leading to an insufficient food supply to sustain the human population. Apart from relying on natural plant immune systems to combat biological agents or waiting for the appropriate evolutionary steps to occur over time, researchers are currently seeking new breakthrough methods to boost disease resistance in plants through genetic engineering. Here, we summarize the past two decades of research in disease resistance engineering against an assortment of pathogens through modifying the plant immune components (internal and external) with several biotechnological techniques. We also discuss potential strategies and provide perspectives on engineering plant immune systems for enhanced pathogen resistance and plant fitness.

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“…Successful vascular wilt pathogens achieve spread throughout xylem vessels by degrading cell walls and pit membranes and invading parenchyma cells while resistant hosts detect MAMPs, DAMPs, or secreted virulence factors and prevent systemic spread (Choi & Klessig, 2016 ). It is noteworthy that an already well‐characterized immune receptor (PRR) from the model plant Arabidopsis thaliana , known as ELONGATION FACTOR‐TU RECEPTOR (EFR), which recognizes the conserved bacterial PAMP EF‐Tu and derived elf peptides, was recently shown to confer increased resistance against Xf when expressed in sweet orange, a conditionally susceptible host of this microbe (Mitre et al, 2021 ).…”

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confidence: 99%

“…In summary, our findings open up new research possibilities and encourage further investigation and identification of the related PRRs that could be a potential biotechnological tool to confer broad‐spectrum disease resistance against Xf. Quite recently, the expression of a PRR receptor in sweet orange was reported to confer ligand‐dependent activation of defence responses against a citrus‐infecting strain of Xf (Mitre et al, 2021 ).…”

mentioning

confidence: 99%

Expression of putative effectors of different Xylella fastidiosa strains triggers cell death‐like responses in various Nicotiana model plants

Sertedakis

Kotsaridis

Tsakiri

et al. 2021

Molecular Plant Pathology

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The Arabidopsis immune receptor EFR increases resistance to the bacterial pathogens Xanthomonas and Xylella in transgenic sweet orange

Cited by 32 publications

References 11 publications

Tackling multiple bacterial diseases of Solanaceae with a handful of immune receptors

Tackling multiple bacterial diseases of Solanaceae with a handful of immune receptors

Engineering plant immune circuit: walking to the bright future with a novel toolbox

Expression of putative effectors of different Xylella fastidiosa strains triggers cell death‐like responses in various Nicotiana model plants

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