The <i>Akkermansia muciniphila</i> is a gut microbiota signature in psoriasis

Tan, Lirong; Zhao, Shuang; Zhu, Wu; Wu, Lisha; Li, Jie; Shen, Min; Chen, Xiang

doi:10.1111/exd.13463

Cited by 164 publications

(172 citation statements)

References 48 publications

(52 reference statements)

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“…However, there is no clear pattern of gut microbial dysbiosis among these autoimmune diseases. The lower microbial diversity detected in our study has been reported previously for other cohorts of patients with psoriasis but not in other studies . Lower diversity in patients with autoimmune disease has also been described for rheumatoid arthritis and Crohn disease .…”

Section: Discussionsupporting

confidence: 77%

“…The lower microbial diversity detected in our study has been reported previously for other cohorts of patients with psoriasis 49 but not in other studies. 50,51 Lower diversity in patients with autoimmune disease has also been described for rheumatoid arthritis 47 and Crohn disease. 46,48 On the other hand, no reduction in the microbiota diversity was detected in the case of multiple sclerosis, 52 type 1 diabetes, 13 lupus erythematosus 31 or myasthenia gravis.…”

Section: Discussionmentioning

confidence: 86%

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Gut microbiota dysbiosis in a cohort of patients with psoriasis

et al. 2019

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Summary Background There is increasing evidence of the key role that the gut microbiota plays in inflammatory diseases. Objectives To identify differences in the faecal microbial composition of patients with psoriasis compared with healthy individuals in order to unravel the microbiota profiling in this autoimmune disease. Methods 16S rRNA gene sequencing and bioinformatic analyses were performed with the total DNA extracted from the faecal microbiota of 19 patients with psoriasis and 20 healthy individuals from the same geographic location. Results Gut microbiota composition of patients with psoriasis displayed a lower diversity and different relative abundance of certain bacterial taxa compared with healthy individuals. Conclusions The gut microbiota profile of patients with psoriasis displayed a clear dysbiosis that can be targeted for microbiome‐based therapeutic approaches. What's already known about this topic? Psoriasis is a chronic inflammatory immune‐mediated skin disease, the aetiology of which remains unclear. The human microbiota is a complex microbial community that inhabits our body and has been related with the maintenance of a healthy status. Several studies have focused on the skin microbiome and its connection with psoriasis although less attention has been focused on the potential role of the gut microbiota in psoriatic disease. What does this study add? This study unravels the gut microbiome dysbiosis present in a cohort of patients with psoriasis, compared with a healthy control group from the same geographical location. This study shows a lower bacterial diversity and different relative abundance of certain bacterial taxa in patients with psoriasis. We gain knowledge and insight into the microbiome alterations in psoriatic disease, opening new avenues for therapeutic approaches to reshape the human microbiome towards a healthy status.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 86%

Gut microbiota dysbiosis in a cohort of patients with psoriasis

et al. 2019

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“…Significantly reduced abundance of Akkermansia muciniphila was observed among patients with psoriasis. Similar observations have been made in case of IBD and obesity, which also share a common pathological background with psoriasis including Th 17 , Th 1 and T reg role in immune response . Moreover, it has been suggested that gut microbiota control imiquimod‐induced murine model of psoriasis skin lesions by altering the T cells response …”

Section: Methodssupporting

confidence: 70%

“…Similar observations have been made in case of IBD and obesity, which also share a common pathological background with psoriasis including Th 17 , Th 1 and T reg role in immune response. 52 Moreover, it has been suggested that gut microbiota control imiquimod-induced murine model of psoriasis skin lesions by altering the T cells response. 37 Another study inspecting psoriasis patients faecal microflora composition showed an increased abundance of phylum Firmicutes and decreased abundance of phylum Bacteroidetes.…”

Section: Psoriasis and Psoriatic Arthritismentioning

confidence: 99%

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska

Gerkowicz

Krasowska

2019

Acad Dermatol Venereol

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The human microbiome is a wide range of microorganisms residing in and on our body. The homeostasis between host immune system and the microbial environment allows mutual benefits and protection. Physiological bacterial colonization is essential for the establishment of organism immunity. The human microbiota ecosystem can be divided into several compartments, out of which intestinal flora strongly affects our health and plays a crucial role in the pathophysiology of many diseases. The gastrointestinal tract, being a major guardian of the immune system, maintains the homeostasis with the commensal microorganisms by tolerating the typical flora antigens. The dysbiosis may trigger an inflammatory response followed by tissue damage or autoimmune processes. The gut microbiome alterations are linked to the pathogenesis of the allergic, cardiovascular, gastrointestinal, metabolic, neurodevelopmental, psychiatric and neurodegenerative diseases and cancer. Moreover, there is increasing evidence connecting the skin condition with the gastrointestinal microbiome, which has been described as the skin–gut axis. The aim of this study was to review the literature regarding the role of the gut microbiome alterations in the pathogenesis of selected allergic and inflammatory skin diseases.

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“…au identificat o diversitate microbiană redusă în cazul pacienţilor cu PS, cu o abundenţă relativă scăzută pentru Actinobacteria şi Bacteroidetes (23). Suplimentar, la pacienţii cu PS, disbioza de la nivel intestinal se caracterizează prin abundenţă redusă a Faecalibacterium praunitzii (24,25) şi a Akkermansia muciniphila (26). Huang şi colab.…”

Section: Intestinalunclassified

Studiul microbiomului la pacienţii cu psoriazis

Manole¹,

Ţiplica²

2019

Ro Med J.

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REzumatPsoriazisul este o afecţiune cutanată ce apare ca urmare a interacţiunii dintre factori genetici predispozanţi, factori imunologici şi triggeri externi. Studiile efectuate au evidenţiat rolul important deţinut de stafilococul auriu sau de streptococul Pyogenes în inducerea, întreţinerea sau exacerbarea leziunilor de psoriazis. Astfel, se consideră că studiul microbiomului cutanat la pacienţii cu psoriazis este extrem de important şi complementar cercetărilor din domeniul genetic şi imunologic. Progresele noi în tehnologiile de secvențiere de nouă generație permit o mai bună înțelegere privind alterarea mecanismelor genetice în psoriazis. Studiile efectuate până în prezent relatează rezultate variabile, aparent din cauza limitărilor pe care le asociază, fapt ce impune ca măsură prioritară realizarea unui protocol standardizat al proceselor de recoltare şi prelucrare a probelor analizate.Cuvinte cheie: psoriazis, microbiom, secvenţiere de nouă generaţie aBStRaCt Psoriasis is a skin condition that occurs as a result of the interaction between predisposing genetic factors, immunological factors and external triggers. Studies have highlighted the important role played by Staphylococcus aureus or Streptococcus pyogenes in inducing, maintaining or exacerbating psoriasis lesions. Thus, the study of skin microbe in patients with psoriasis is considered to be extremely important and complementary to genetic and immunological research. New advances in new generation sequencing technologies allow for a better understanding of genetic mechanisms alteration in psoriasis. Studies performed so far show variable results, apparently due to the associated limitations, which imply that a standardized protocol for the sampling and processing of analyzed samples is a priority measure.

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The Akkermansia muciniphila is a gut microbiota signature in psoriasis

Cited by 164 publications

References 48 publications

Gut microbiota dysbiosis in a cohort of patients with psoriasis

Gut microbiota dysbiosis in a cohort of patients with psoriasis

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Studiul microbiomului la pacienţii cu psoriazis

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