The<i>ACACB</i>gene rs2268388 polymorphism is associated with nephropathy in Caucasian patients with diabetes: a meta-analysis

An, Li; Jiang, Hao; Tang, Ri‐Ning

doi:10.3109/0886022x.2015.1052978

Cited by 8 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although a literature search did not nd publications on polymorphisms in ACACB in yaks, several studies have suggested that the gene is associated with traits related to fat metabolism in cattle. In human studies, ACACB genetic variants have been associated with metabolic syndrome, the onset of type II diabetes, kidney disease, and obesity in postmenopausal women 23,31,32 . In pigs, ACACB was shown to be associated with lipid metabolic processes and obesity in Meishan pigs 33 .…”

Section: Discussion 1 Genetic Characterization Of Acacb In the Gannan...mentioning

confidence: 99%

Polymorphisms of ACACB Gene and Their Association with Milk Quality Traits in Yak

zhu,

Wang,

et al. 2024

Preprint

View full text Add to dashboard Cite

Acetyl-CoA carboxylase beta (ACACB) is a rate-limiting enzyme involved in lipid syn-thesis and fatty acid oxidation. The results of our previous study showed that a total of seven SNPs were detected in the exon 37-intron 37, exon 46-intron 46, and intron 47 regions of the yak ACACB, and mutations in the ACACB were found to affect yak meat quality traits. However, the genetic effects of ACACB on yak milk quality traits have not been reported. Therefore, the aim of this study was to investigate the effects of ACACB polymorphisms on yak milk quality traits in Gannan yaks. In this study, A total of 202 Gannan yaks were included in the study. Analyze the different geno-types, diplotypes, and the presence or absence of haplotypes on milk quality. The seven SNPs were named as exon 37-intron 37 (exon 37: SNP1, intron 37: SNP2 and SNP3), exon 46-intron 46 (exon 46: SNP4, intron 46: SNP5), and intron 47 (SNP6 and SNP7). Apart from the SNP1, SNP2, SNP5, and SNP6 loci where the polymorphic information content (PIC) was low (PIC ≤ 0.25), the SNP3, SNP4, and SNP7 loci were all of intermediate polymorphic information status (0.25 < PIC < 0.5). The highest frequency of heterozygosity occurred at the SNP7 locus, and the two alleles were evenly distributed in the population compared to alleles at the other loci. There were no strong linkages between the SNPs (r2<0.33) except for a strong linkage disequilibrium observed between SNP1 and SNP2 (r2=0.89). Seven effective haplotypes and seven diplotypes were constructed for the Gannan yak ACACB gene. Correlation analysis showed that SNP1 and SNP7 were associated with lactose content (P<0.05), while SNP3 was significantly associated with the protein and monounsaturated fatty acid contents in the milk (P<0.05). SNP4 was significantly associated with both saturated and monounsaturated fatty acid contents (P<0.05 and P<0.01, respectively), while SNPs 5 and 7 were significantly correlated with the fat percentage (P<0.05) and SNP6 was significantly correlated with total solid content of the milk (P<0.05). Yaks with the H2H2 diplotype had significantly higher levels of milk fat than other diplotypes (P<0.05) while milk fat contents in animals carrying hap-lotype H2 were significantly higher than that in yaks carrying the deletion type (P<0.05). The findings of the present study suggest that polymorphisms in the yak ACACB affect milk quality and can be used as genetic markers for enhancing milk quality in yak populations. The findings provide a theoretical basis for the genetic characterization of milk quality traits in the Gannan yak.

show abstract

Section: Discussion 1 Genetic Characterization Of Acacb In the Gannan...mentioning

confidence: 99%

Polymorphisms of ACACB Gene and Their Association with Milk Quality Traits in Yak

zhu,

Wang,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…An et al analysed 12 case-control studies containing 3273 cases and 3242 controls, which indicated that there are significant associations between the ACACB gene, rs2268388 polymorphism, and diabetic nephropathy among Caucasian patients with diabetes. Some case reports also suggested that ACACB expression may be related to obesity [41]. For example, the Corbett et al study used ACACB as a target in the design of isozyme-nonselective acetyl-CoA carboxylase inhibitors in obese mice [42].…”

Section: Discussionmentioning

confidence: 99%

Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis

et al. 2021

View full text Add to dashboard Cite

Objectives Adipocytes and adipocyte lipid metabolism are closely related with obesity and type 2 diabetes, but the molecular mechanism still needs further investigation. The aim of this study is to discover the adipocyte genes and pathways involved in obesity and type 2 diabetes using bioinformatics analysis. Methods The GSE27951 gene expression profile was obtained. Software and online tools (STRING, Cytoscape, BioGPS, CTD, and FunRich) were used to identify core genes.21 human subcutaneous adipose samples, with 10 from type 2 diabetic patients and 11 from normal controls, were included in these analyses. Results 184 differentially expressed genes (DEGs) including 42 up-regulated genes and 142 downregulated genes were found to be enriched in metabolism, receptor activity, collagen type IV and glutamine biosynthesis I pathway by using the enrichment analysis. Seven hub genes were identified from the PPI network using various software (Cytoscape, STRING, BioGPS, and CTD). Four core genes (COL4A2, ACACB, GLUL, and CD36) were found to be highly expressed in subcutaneous adipose tissue of obese patients accompanying type 2 diabetes. Conclusion COL4A2, ACACB, GLUL and CD36 might be the core molecular biomarkers of obesity in patients with or without type 2 diabetes.

show abstract

“…Acetyl-CoA carboxylase beta gene knockout mice have sustained fatty acid oxidation in the adipocytes, conferring protective effects against obesity and diabetes [27]. Furthermore, in women with kidney disease and postmenopausal women, ACACB variants are associated with obesity and type II diabetes [28,29]. Moreover, in Alentejana bulls, ACACB is associated with the IMF content and fatty acid composition of beef [30].…”

Section: Introductionmentioning

confidence: 99%

Variation in Acetyl-CoA Carboxylase Beta Gene and Its Effect on Carcass and Meat Traits in Gannan Yaks

Zhu,

Qi,

Wang

et al. 2023

IJMS

View full text Add to dashboard Cite

Acetyl-CoA carboxylase beta (ACACB) is a functional candidate gene that impacts fat deposition. In the present study, we sequenced exon 37–intron 37, exon 46–intron 46, and intron 47 of yak ACACB using hybrid pool sequencing to search for variants and genotyped the gene in 593 Gannan yaks via Kompetitive allele-specific polymerase chain (KASP) reaction to determine the effect of ACACB variants on carcass and meat quality traits. Seven single nucleotide polymorphisms were detected in three regions. Eight effective haplotypes and ten diplotypes were constructed. Among them, a missense variation g.50421 A > G was identified in exon 37 of ACACB, resulting in an amino acid shift from serine to glycine. Correlation analysis revealed that this variation was associated with the cooking loss rate and yak carcass weight (p = 0.024 and 0.012, respectively). The presence of haplotypes H5 and H6 decreased Warner–Bratzler shear force (p = 0.049 and 0.006, respectively), whereas that of haplotypes H3 and H4 increased cooking loss rate and eye muscle area (p = 0.004 and 0.034, respectively). Moreover, the presence of haplotype H8 decreased the drip loss rate (p = 0.019). The presence of one and two copies of haplotypes H1 and H8 decreased the drip loss rate (p = 0.028 and 0.004, respectively). However, haplotype H1 did not decrease hot carcass weight (p = 0.011), whereas H3 increased the cooking loss rate (p = 0.007). The presence of one and two copies of haplotype H6 decreased Warner–Bratzler shear force (p = 0.014). The findings of the present study suggest that genetic variations in ACACB can be a preferable biomarker for improving yak meat quality.

show abstract

TheACACBgene rs2268388 polymorphism is associated with nephropathy in Caucasian patients with diabetes: a meta-analysis

Cited by 8 publications

References 21 publications

Polymorphisms of ACACB Gene and Their Association with Milk Quality Traits in Yak

Polymorphisms of ACACB Gene and Their Association with Milk Quality Traits in Yak

Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis

Variation in Acetyl-CoA Carboxylase Beta Gene and Its Effect on Carcass and Meat Traits in Gannan Yaks

Contact Info

Product

Resources

About