The Hypothalamic Preoptic Area and Body Weight Control

Yu, Sangho; François, Marie; Huesing, Clara; Münzberg, Heike

doi:10.1159/000479875

Cited by 38 publications

(28 citation statements)

References 83 publications

(87 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The functions of the POA in the hypothalamus are very complicated. It has been shown that POA is a critical region for thermoregulation and energy balance (Boulant, 2000;Yu et al, 2018). Some sub-areas like the MPO region are associated with sexual behavior (Merari and Ginton, 1975;Dominguez and Hull, 2005;Wei et al, 2018).…”

Section: Innervation In the Hypothalamic Areamentioning

confidence: 99%

Mapping Central Projection of Oxytocin Neurons in Unmated Mice Using Cre and Alkaline Phosphatase Reporter

Liao

Chiu

et al. 2020

Front. Neuroanat.

View full text Add to dashboard Cite

Section: Innervation In the Hypothalamic Areamentioning

confidence: 99%

Mapping Central Projection of Oxytocin Neurons in Unmated Mice Using Cre and Alkaline Phosphatase Reporter

Liao

Chiu

et al. 2020

Front. Neuroanat.

View full text Add to dashboard Cite

“…Integrative temperature information in the POA is then transmitted to various brain sites that modulate physiological and behavioral thermal responses 9 , 10 . In addition to thermoregulation, the POA also monitors metabolic state and regulates food intake 11 . The dual functions of the POA in maintaining temperature and energy balance suggest the hypothesis that this region may coordinate the thermal and metabolic responses to energy deficiency.…”

Section: Introductionmentioning

confidence: 99%

Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice

Zhi

Reis

et al. 2020

Nat Commun

View full text Add to dashboard Cite

Homeotherms maintain a stable internal body temperature despite changing environments. During energy deficiency, some species can cease to defend their body temperature and enter a hypothermic and hypometabolic state known as torpor. Recent advances have revealed the medial preoptic area (MPA) as a key site for the regulation of torpor in mice. The MPA is estrogen-sensitive and estrogens also have potent effects on both temperature and metabolism. Here, we demonstrate that estrogen-sensitive neurons in the MPA can coordinate hypothermia and hypometabolism in mice. Selectively activating estrogen-sensitive MPA neurons was sufficient to drive a coordinated depression of metabolic rate and body temperature similar to torpor, as measured by body temperature, physical activity, indirect calorimetry, heart rate, and brain activity. Inducing torpor with a prolonged fast revealed larger and more variable calcium transients from estrogen-sensitive MPA neurons during bouts of hypothermia. Finally, whereas selective ablation of estrogen-sensitive MPA neurons demonstrated that these neurons are required for the full expression of fasting-induced torpor in both female and male mice, their effects on thermoregulation and torpor bout initiation exhibit differences across sex. Together, these findings suggest a role for estrogen-sensitive MPA neurons in directing the thermoregulatory and metabolic responses to energy deficiency.

show abstract

“…For example, rats with POA lesions had difficulty not only maintaining core temperature but also adjusting food intake upon ambient temperature changes ( Hamilton, 1963 ; Hamilton and Brobeck, 1964 ). Despite its prominent role in regulating energy expenditure and implication in controlling food intake, the POA has not been investigated as an important brain area for body weight regulation ( Yu et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Preoptic leptin signaling modulates energy balance independent of body temperature regulation

Cheng

François

et al. 2018

eLife

Self Cite

View full text Add to dashboard Cite

The adipokine leptin acts on the brain to regulate energy balance but specific functions in many brain areas remain poorly understood. Among these, the preoptic area (POA) is well known to regulate core body temperature by controlling brown fat thermogenesis, and we have previously shown that glutamatergic, long-form leptin receptor (Lepr)-expressing neurons in the POA are stimulated by warm ambient temperature and suppress energy expenditure and food intake. Here we further investigate the role of POA leptin signaling in body weight regulation and its relationship to body temperature regulation in mice. We show that POA Lepr signaling modulates energy expenditure in response to internal energy state, and thus contributes to body weight homeostasis. However, POA leptin signaling is not involved in ambient temperature-dependent metabolic adaptations. Our study reveals a novel cell population through which leptin regulates body weight.

show abstract

The Hypothalamic Preoptic Area and Body Weight Control

Cited by 38 publications

References 83 publications

Mapping Central Projection of Oxytocin Neurons in Unmated Mice Using Cre and Alkaline Phosphatase Reporter

Mapping Central Projection of Oxytocin Neurons in Unmated Mice Using Cre and Alkaline Phosphatase Reporter

Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice

Preoptic leptin signaling modulates energy balance independent of body temperature regulation

Contact Info

Product

Resources

About