ObjectiveTo evaluate whether critically ill children with systemic inflammatory response syndrome (SIRS) or sepsis have altered resting energy expenditure (REE) and substrate utilization.
Summary Background DataStudies in adults with sepsis have shown increased energy expenditure and mobilization of endogenous fat. In infants and children, energy metabolism and substrate utilization during sepsis have not been characterized.
MethodsMetabolic studies were performed in 21 critically ill children with SIRS or sepsis. Twenty-one stable control children, matched for weight, were also studied. Seven patients required inotropic support and 17 received mechanical ventilation. Fifteen patients with SIRS had evidence of bacterial, fungal, or viral infection and were considered septic. Respiratory gas exchange was measured by computerized indirect calorimetry for 1 to 2 hours continuously.
ResultsThe REE of patients with SIRS or sepsis was not different from that of controls. Similarly, there were no differences in carbon dioxide production and oxygen consumption. Resting energy metabolism was not different between patients with SIRS and patients with sepsis. In addition, the presence of low platelet count or inotropic support did not affect resting energy metabolism. The median respiratory quotient of patients with SIRS or sepsis was 0.88 (range 0.75-1.12), indicating mixed utilization of fat and carbohydrate; this was not significantly different from that of controls. The Pediatric Risk of Mortality Score was not significantly correlated with REE or respiratory quotient.
ConclusionsThe energy requirements of children with SIRS or sepsis are not increased. Their resting metabolism is based on both carbohydrate and fat utilization. The authors speculate that these children divert the energy for growth into recovery processes.Studies in adults have shown that the metabolic response to trauma and sepsis is characterized by hypermetabolism and increased tissue catabolism.1 Plank et al 2 have found that resting energy expenditure (REE) in adults with severe sepsis resulting from peritonitis increases up to 49% above normal and remains high for at least 3 weeks from the onset of disease. Hypermetabolism in these patients is associated with lipolysis and catabolism despite increased caloric intake.1,2 The energy requirement of adult patients with critical illness or those undergoing severe stress is thought to be increased by 30% above normal.3 Van Lanschot et al 4 have shown that energy expenditure measured by indirect calorimetry in these patients is greater than energy expenditure predicted on the basis of body size and age.There is little information on the metabolic response to critical illness in infancy and childhood. Preliminary studies 5,6 have not demonstrated a hypermetabolic response similar to that described in adults.2,4 Chwals et al 5 measured REE by indirect calorimetry in critically ill ventilated infants and young children and showed that the measured