The Hypotensive Action of B.W. 467c60

Smirk, Horace

doi:10.1016/s0140-6736(63)91565-4

Cited by 23 publications

(12 citation statements)

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“…The predominance of the parasympathetic system over the sympathetic system after the blockade of the latter leads to increased gastrointestinal activity. Other factors are probably involved since bethanidine is a potent neuron blocking agent but produces significantly less diarrhea than guanethidine in man (SMIRK, 1963). Diarrhea did not occur following subcutaneous administration of bethanidine to guinea pigs.…”

Section: Effects Due To Administration In Vivo A) Consequences Of Adrmentioning

confidence: 96%

“…The duration of the hypotensive action of bethanidine was relatively short. The onset of action occurred within 2 h, was maximal in 4 to 5 h and had a total duration of effect between 8 and 12 h (SMIRK, 1963;JOHNSTON et al, 1964;MOSER, 1969).…”

Section: Bethanidinementioning

confidence: 97%

“…Clinical trials with bethanidine have shown that the hemodynamic effects in hypertensive patients are similar to those produced by guanethidine treatment (MONTUSCHI and PICKENS, 1962;JOHNSON et al, 1962;SMIRK, 1963;FEWINGS et al, 1964;BATH et al, 1967). PRICHARD et al (1968) did not show any significant difference between bethanidine and guanethidine in their ability to lower and control blood pressure in hypertensive patients.…”

Section: -------------------------------mentioning

confidence: 98%

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Adrenergic Neuron Blocking Drugs

Maxwell¹,

Wastila²

1977

Antihypertensive Agents

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Section: Effects Due To Administration In Vivo A) Consequences Of Adrmentioning

confidence: 96%

Section: Bethanidinementioning

confidence: 97%

Section: -------------------------------mentioning

confidence: 98%

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Adrenergic Neuron Blocking Drugs

Maxwell¹,

Wastila²

1977

Antihypertensive Agents

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“…Bethanidine (BW467C60), a recently introduced potent adrenergic neurone blocking agent, has a hypotensive action in man (Montuschi & Pickens, 1962;Smirk, 1963). Its effect on the sympathetic nerve stimulus frequency/ nictitating membrane response curves lies between those of bretylium and guanethidine (Boura & Green, 1963).…”

mentioning

confidence: 99%

Comparison of the Effects of Bretylium, Guanethidine and Bethanidine on Smooth Muscle Responses to Different Rates of Sympathetic Nerve Stimulation

Green

Robson

1964

British Journal of Pharmacology and Chemotherapy

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The relative effects of bretylium, guanethidine and bethanidine on smooth muscle responses to different rates of sympathetic nerve stimulation have been compared. The responses studied were vasoconstriction in the femoral vascular bed and contraction of the spleen in anaesthetized cats, vasoconstriction in perfused ears of rabbits and inhibition of pendular movements in rabbit isolated ileum preparations. Except in the isolated ileum, the action of bretylium on curves relating the frequency of nerve stimulation and the effect on response was different from that of guanethidine.Whereas bretylium caused relatively greater inhibition of responses to high stimulus frequencies and depressed the slopes of the curves, guanethidine preferentially suppressed responses to low stimulus frequencies and caused roughly parallel shifts of the curves. In each situation tested bethanidine was the most potent of the three blocking agents and in general its effect on frequency/response curves was intermediate between those of bretylium and guanethidine.

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“…Bethanidine itself was the preferred compound. Other clinical reports that followed soon after were also generally favourable (Johnston et al, 1962;Smirk, 1962Smirk, , 1963 Green, 1981). First is the clue dating from 1954 that the alimen-TM1O has a powerful local anaesthetic action of iterion was unusually long persistence (Hey & Willey, 1954).…”

mentioning

confidence: 89%

The discovery of bretylium and bethanidine.

Af¹

1982

Brit J Clinical Pharma

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The Hypotensive Action of B.W. 467c60

Cited by 23 publications

References 0 publications

Adrenergic Neuron Blocking Drugs

Adrenergic Neuron Blocking Drugs

Comparison of the Effects of Bretylium, Guanethidine and Bethanidine on Smooth Muscle Responses to Different Rates of Sympathetic Nerve Stimulation

The discovery of bretylium and bethanidine.

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