The Hyponatremia Epidemic: A Frontier Too Far?

Drake-Holland, Angela J.; Noble, Mark I. M.

doi:10.3389/fcvm.2016.00035

Cited by 6 publications

(5 citation statements)

References 43 publications

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“…This has a synergistic effect with the poor cardiac reserve and contributes to the relatively lower peripheral resistance in the obese secondary to suppressed sympathetic output. This, coupled with the relative hemodilution seen in the obese, results in hyponatremia [28].…”

Section: Discussionmentioning

confidence: 99%

Pre-Operative Hyponatremia in a High Dependency Cardiovascular Surgical Center of a Tertiary Health Facility in Nigeria: Risk Factors, Prevalence, Clinical Correlates and Treatment Outcome. A Retrospective Cohort Study

Uduagbamen¹,

Sanusi²,

Udom³

et al. 2020

OJIM

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Introduction: Hyponatremia is the commonest electrolyte derangement seen in medical and surgical wards and in high dependency treatment units. It is associated with prolonged hospital stay, high economic burden and increased morbidity and mortality. Hyponatremia is well reported in medical and surgical conditions but literature is scanty concerning its relationship with treatment outcome in patients managed in high dependency heart and vascular surgical centers. Objectives: To determine the prevalence, determinants, clinical correlates and outcome of pre-operative hyponatremia. Methods: Retrospective study involving patients that had surgery (cardiac and vascular) between January 2015 and December 2019. Data were obtained from patients' case files, perioperative and intensive unit charts. All participants with preoperative hyponatremia had their serum sodium corrected to ≥135 mmol before surgical incision and those with hypernatremia had their sodium corrected to <145 mmol. The socio-demographic, clinical, laboratory findings were entered. Statistical analysis was done using student's t-test and Chi square. Results: Of the 305 participants (186 males and 119 females), pre-operative How to cite this paper: Uduagbamen,

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Section: Discussionmentioning

confidence: 99%

Pre-Operative Hyponatremia in a High Dependency Cardiovascular Surgical Center of a Tertiary Health Facility in Nigeria: Risk Factors, Prevalence, Clinical Correlates and Treatment Outcome. A Retrospective Cohort Study

Uduagbamen¹,

Sanusi²,

Udom³

et al. 2020

OJIM

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“…Hyponatremia, defined as a serum sodium concentration <136meq/L, is a frequent electrolyte disorder in the general population [1][2][3] and in hospitalized patients. Mild cases are usually asymptomatic, but severe hyponatremia may cause a high mortality [8] depending its underlying disorder.…”

Section: Discussionmentioning

confidence: 99%

“…Hyponatremia is the common electrolyte disorder with serum sodium level < 135nmol/L seen in 1% of the general population , in which upto 30% of all patients treated in intensive care units. [1][2][3] In most cases , hyponatremia is the leading laboratory sign of hypopituitarism. Hypopituitarism is a rare condition that is often misdiagnosed and in elderly it is an under-investigated endocrine disorder, since its clinical features are unspecific and more often attributed to aging itself and related comorbidities [4][5].…”

Section: Introductionmentioning

confidence: 99%

A Case Report on Hyponatremia: Leading Sign of Hypopituitarism [Secondary to Adrenal Insufficiency]

Poornima¹,

Elizabeth²

2020

IJISRT

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Severe hyponatremia due to hypopituitarism and adrenal insufficiency can be life threatening and treatment with glucocorticoids is very effective once the diagnosis of the underlying disorder has been made. In our experience, the diagnosis of hypopituitarism in hyponatremic patients is often overlooked. We report the case of a 54 year old female admitted to our hospital in an obtunded state with altered sensorium. We found that a severe hyponatremia was the cause of patient condition . Previously she was diagnosed with recurrent episodes of hyponatremia leading to encephalopathy. The diagnosis of hypopituitarism is often overlooked in hyponatremic patients. Hyponatremia should always be ruled out for endocrinological cause Our study concludes that hyponatremia is due to hypopituitarism that is secondary to adrenal insufficiency leading to encephalopathy.

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“…Hyponatremia in terminal patients has been associated with a wide range of detrimental symptoms and signs 31. Establishing the etiology of hyponatremia is essential for treatment.…”

Section: Discussionmentioning

confidence: 99%

Pressure ulcers in palliative ward patients: hyponatremia and low blood pressure as indicators of risk

Sternal¹,

Wilczyński²,

Szewieczek³

2016

CIA

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BackgroundPrevention strategies for pressure ulcer formation remain critical in patients with an advanced illness. We analyzed factors associated with the development of pressure ulcers in patients hospitalized in a palliative care ward setting.Patients and methodsThis study was a retrospective analysis of 329 consecutive patients with a mean age (± standard deviation) of 70.4±11.8 years (range: 30–96 years, median 70.0 years; 55.3% women), who were admitted to the Palliative Care Department between July 2012 and May 2014.ResultsPatients were hospitalized for mean of 24.8±31.4 days (1–310 days, median 14 days). A total of 256 patients (77.8%) died in the ward and 73 patients (22.2%) were discharged. Two hundred and six patients (62.6%) did not develop pressure ulcers during their stay in the ward, 84 patients (25.5%) were admitted with pressure ulcers, and 39 patients (11.9%) developed pressure ulcers in the ward. Four factors assessed at admission appear to predict the development of pressure ulcers in the multivariate logistic regression model: Waterlow score (odds ratio [OR] =1.140, 95% confidence interval [CI] =1.057–1.229, P=0.001), transfer from other hospital wards (OR =2.938, 95% CI =1.339–6.448, P=0.007), hemoglobin level (OR =0.814, 95% CI =0.693–0.956, P=0.012), and systolic blood pressure (OR =0.976, 95% CI =0.955–0.997, P=0.023). Five other factors assessed during hospitalization appear to be associated with pressure ulcer development: mean evening body temperature (OR =3.830, 95% CI =1.729–8.486, P=0.001), mean Waterlow score (OR =1.194, 95% CI =1.092–1.306, P<0.001), the lowest recorded sodium concentration (OR =0.880, 95% CI =0.814–0.951, P=0.001), mean systolic blood pressure (OR =0.956, 95% CI =0.929–0.984, P=0.003), and the lowest recorded hemoglobin level (OR =0.803, 95% CI =0.672–0.960, P=0.016).ConclusionHyponatremia and low blood pressure may contribute to the formation of pressure ulcers in patients with an advanced illness.

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The Hyponatremia Epidemic: A Frontier Too Far?

Cited by 6 publications

References 43 publications

Pre-Operative Hyponatremia in a High Dependency Cardiovascular Surgical Center of a Tertiary Health Facility in Nigeria: Risk Factors, Prevalence, Clinical Correlates and Treatment Outcome. A Retrospective Cohort Study

Pre-Operative Hyponatremia in a High Dependency Cardiovascular Surgical Center of a Tertiary Health Facility in Nigeria: Risk Factors, Prevalence, Clinical Correlates and Treatment Outcome. A Retrospective Cohort Study

A Case Report on Hyponatremia: Leading Sign of Hypopituitarism [Secondary to Adrenal Insufficiency]

Pressure ulcers in palliative ward patients: hyponatremia and low blood pressure as indicators of risk

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