The Hypoglycaemia Effect of &lt;i&gt;Telfaria occidentalis&lt;/i&gt; Aqueous Leaf Extract in Rats

Emudianughe, T. S.; Aderibigbe, AO

doi:10.4314/wajpdr.v18i1.14720

Cited by 3 publications

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“…In the present study, there were significant reductions in the plasma glucose of rats that received both doses of TO for 7 days and 100 mg/kg (but not 200 mg/kg) of TO for 14 days. These findings are consistent with the previously-reported hypoglycaemic effect of TO [ 7 , 13 , 14 , [17] , [18] , [19] ]. We also observed surges of insulin and glucagon and simultaneous suppression, albeit insignificant, of 2 key hyperglycaemic hormones (adrenaline and cortisol) after 7-day treatment with both doses of TO.…”

Section: Discussionsupporting

confidence: 93%

Counter-regulatory responses to Telfairia occidentalis-induced hypoglycaemia

Salman

Alagbonsi²,

Sulaiman

2020

Metabolism Open

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Background Telfairia occidentalis (TO) has many biological activities including blood glucose regulation. Thus, it is being used in the treatment of diabetes mellitus. TO has been shown to cause insulin-mediated hypoglycaemia, which leads to post-hypoglycaemic hyperglycaemia. However, the mechanism involved in the post-hypoglycaemic hyperglycaemia is still poorly understood. Objective This research was designed to determine the response of glucoregulatory hormones and enzymes to TO treatment. Methods Thirty-five male Wistar rats were divided into seven oral treatment groups (n = 5/group), which received either of 100 mg/kg or 200 mg/kg TO for 7-, 10- or 14 days. Results The 7-day treatment with TO significantly increased the levels of insulin, glucagon, and glucose-6-phosphatase (G6Pase) activity but decreased the levels of glucose, adrenaline, and glucokinase (GCK) activity. The 10-day treatment with 100 mg/kg TO increased glucose and decreased GCK activity while 200 mg/kg for the same duration increased glucose, insulin, GCK and G6Pase activities but reduced glucagon. The 14-day treatment with 100 mg/kg TO decreased glucose and glucagon but increased cortisol, while 200 mg/kg TO for same duration increased insulin, but reduced glucagon and GCK activity. Conclusion The TO’s post-hypoglycaemic hyperglycaemia results from increased glucagon and G6Pase activity, and reduced GCK activity. Moreover, the glucagon response mainly depends on glucose rather than insulin.

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Section: Discussionsupporting

confidence: 93%

Counter-regulatory responses to Telfairia occidentalis-induced hypoglycaemia

Salman

Alagbonsi²,

Sulaiman

2020

Metabolism Open

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“…In support of the present findings by other studies it could be postulated that apart from having inhibitory effect on glucose absorption, it is probable that other mechanisms such as direct stimulation of glycolysis in peripheral tissues, facilitation of glucose entry into peripheral cells, reduced hepatic gluconeogenesis and reduction of plasma glucagon levels may be in operation. 20,21 Commelina Africana and Ageratum conyzoides have both been known to contain alkaloids, some of which may be associated with the improvement in the symptoms of diabetes mellitus. 22 The causes and sites of intervention in biochemical process in diabetes are diverse .…”

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confidence: 99%

Hypoglycaemic activity of <i>Commelina africana</i> and <i>Ageratum conyzoides</i> in relation to their mineral composition

Agunbiade¹,

Ojezele²,

Ojezele³

et al. 2012

Af Hlth Sci

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Background: Many plants with antidiabetic properties probably act in part through their content of fibre, vitamins, bioactive or mineral content Objectives: This study investigated the mineral, proximate, phytochemical compositions and hypoglycaemic effect of Commelina africana and Ageratum conyzoides extracts in diabetic rats, and the likely relationship between this property and the mineral, proximate and phytochemical compositions of the plants . Methods:The plants were subjected to mineral, proximate composition and phytochemical analysis. Attempt was made to see (if any) the relationship between the hypoglycaemic effect and the mineral, proximate compositions and phytochemistry of the plants. Alloxan-induced diabetic animals were administered 500mg/kg body weight aqueous extracts of the plants and glibenclamide as the reference hypoglycaemic agent. Results: Aqueous extract of Ageratum conyzoides reduced fasting blood glucose of experimental animals by 39.1% while Commelina africana reduced the same by 78.0%. Alkaloids, cardenolides, saponins, and tannins were detected in both plants. Anthraquinones was absent in C. africana but a trace of it was detected in A. conyzoides. The hypoglycaemic effect of Commelina africana was comparable with the reference hypoglycaemic agent. Ageratum conyzoides showed comparably weaker hypoglycaemic effect than exhibited by reference hypoglycaemic agent. Comparatively, Commelina africana had higher mineral concentrations (except Na) than Ageratum conyzoides. Conclusions: Plants' extracts minerals (magnesium, potassium and iron) and bioactive components (alkaloids and cardenolides) seemingly enhanced their hypoglycaemic effect. Furthermore, these minerals, alkaloids and cardenolides could be helpful in ameliorating complications of diabetes like hypertension and cardiovascular disease.

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“…These potentials include: anticonvulsant (Gbile, 1986), antioxidant and hepatoprotective activity (Oboh, 2005;Oboh, 2006;Bolaji and Olabode, 2011), antidiabetic activity (Aderibigbe et al, 1999;Emudianughe and Aderibigbe, 2002;Eseyin et al, 2007;Eseyin et al, 2010a;Eseyin et al, 2010b;Eseyin et al, 2010c;Eseyin et al, 2014b), anti-cancer (Ejike and Ezeanyika, 2011a;Ejike and Ezeanyika, 2011b;Okokon et al, 2012a), anti-inflammatory and analgesic (Oluwole et al, 2003;Okokon et al, 2012b), hematological (Iweala and Obidoa, 2009;Fasuyi and Nonyerem, 2007;Hamlin and Latunde-Dada, 2011;Alada, 2000;Odede et al, 2010;Osuntoki and Sanusi, 2007). Specifically, the antimicrobial properties T. occidentalis have also been reported (Okokon et al, 2007;Okokon, et al, 2009;Odoemena and Essien, 1995;Noumedem et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Proximate, Anti-Nutrient and Vitamin Composition of Full-Fat and Defatted Seed Flour of Telfairia occidentalis

Alozie

Udo

Orisa

2017

Turkish JAF Sci.Tech.

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Studies were conducted to determine the proximate and anti-nutrient composition of fullfat and defatted seed flour of Telfairia occidentalis (fluted pumpkin) using standard procedures. The defatted seed flour (DSF) indicated higher protein content (46.55%) while the full-fat seed flour (FSF) presented a value of 10.20%. The lipid (35.78%), carbohydrate (42.27%), and caloric values (531.90 Kcal/100 g) obtained for FSF were respectively higher than values of similar determinations for DSF. The anti-nutritional analyses of the FSF showed slightly higher oxalate content (44.00 mg/100 g) while cyanide, phytate and tannin levels were higher in DSF. The vitamin A composition of FSF (9.18 mg/100 g) was higher than that of DSF (0.84 mg/100 g) while DSF indicated higher vitamin C (74.44 mg/100g) content. These results revealed that the seed flour of Telfairia occidentalis contains an appreciable amount of nutrients and vitamins. The levels of toxicants in both FSF and DSF samples were low and below toxic levels. The seed flour of Telfairia occidentalis can be exploited as a cheap and valuable source of vegetable protein in fortified food products formulation.

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The Hypoglycaemia Effect of <i>Telfaria occidentalis</i> Aqueous Leaf Extract in Rats

Cited by 3 publications

References 0 publications

Counter-regulatory responses to Telfairia occidentalis-induced hypoglycaemia

Counter-regulatory responses to Telfairia occidentalis-induced hypoglycaemia

Hypoglycaemic activity of <i>Commelina africana</i> and <i>Ageratum conyzoides</i> in relation to their mineral composition

Proximate, Anti-Nutrient and Vitamin Composition of Full-Fat and Defatted Seed Flour of Telfairia occidentalis

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