The Hydrolysis of Vitamin B<sub>12</sub>. Studies with Model Amides

Bonnett, R.; Raleigh, James A.; Redman, D. G.

doi:10.1021/ja01085a032

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Amide Hydrolysis1

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1966

1994

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Cited by 7 publications

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“…However, in terms of the steric effect of /3-substituents compared with that of 7-substituents [cf. the rule of six (240) ] a fairly complete rationalization is apparent (49). Thus the propionamides b, d, and e have no ßmethyl groups and on steric grounds would be most labile to Sn2 reaction giving the three mono-, three di-, and one tricarboxylic acids observed.…”

Section: Amide Hydrolysismentioning

confidence: 94%