The Hydrolysis of Dimethylamido-ethoxy-phosphoryl Cyanide (Tabun).

Toxicity of the nerve agent tabun toDaphnia magna, a new experimental species in military toxicology

“…The principal pathway of tabun hydrolysis under neutral conditions is to hydrogen cyanide and O-ethyl-N,N-dimethylamidophosphoric acid, which is then hydrolysed via dimethyl phosphoramidate to phosphoric acid [17]. Of these, the most toxic product is hydrogen cyanide.…”

Development and validation of a sensitive gas chromatography–ammonia chemical ionization mass spectrometry method for the determination of tabun enantiomers in hemolysed blood and plasma of different species

“…The reaction rate can be reduced by lowering the pH value, but hydrolysis cannot be avoided completely [23][24][25][26][27]. At low pH values enzymatic activity of A-esterases in the mammalian blood, spontaneous hydrolysis of some highly toxic O-alkyl methylphosphonofluoridates, inhibition of BChE and AChE by OP and spontaneous reactivation of inhibited cholinesterases are strongly reduced [28][29][30][31].…”

Parameters for Evaluation of the Fate, Transport, and Environmental Impacts of Chemical Agents in Marine Environments

“…Reports of the subsequent reactivity of monoethyl dimethylphosphoramidate conflict. One study reported that the P-O bond is more reactive than the N-P bond toward hydrolysis under basic conditions, 224 whereas a previous investigation of ethyl diethylphosphoramidate and homologues indicated that the N-P bond was the more reactive. 225 The water solubility of Tabun is 98 g/L at 0°C and 72 g/L at 20°C.…”