The Hydroalcoholic Extract of Nasturtium officinale Reduces Lung Inflammation and Oxidative Stress in an Ovalbumin-Induced Rat Model of Asthma

Abstract

Background. Asthma is known as a disease that causes breathing problems in children and adults and is also associated with chronic inflammation and oxidative stress of the airways. Nasturtium officinale (NO) possesses a wide range of pharmacological properties, particularly anti-inflammation and antioxidant potentials. Thus, this study for the first time was aimed to investigate anti-inflammatory and antioxidative activities of NO extract (NOE) in an ovalbumin-induced rat model of asthma. Materials and Methods. Forty-four male Wistar rats were sensitized with ovalbumin (OVA) to induce asthma symptoms. The animals were allocated into five groups: control (C), asthmatic (A), A + NOE (500 mg/kg), NOE (500 mg/kg), and A + dexamethasone (DX, 2.5 mg/kg). After 7 days, blood and tissue samples were taken from the rats. Then, the level of inflammatory markers, oxidative stress parameters, and antioxidant enzymes activity were measured. Results. The obtained results showed that OVA-sensitive rats significantly increased the levels of pro-inflammatory cytokines IL-1B, TGF-β, and SMA-α compared to the control group ( p < 0.05 ), while treatment with NOE remarkably reduced the SMA-α gene expression compared to the asthma group ( p < 0.05 ). Furthermore, it decreased the expression of IL-1B and TNF-α genes, although it was not statistically significant. The level of glutathione peroxidase (GPX) significantly reduced in A group compared to the C group ( p < 0.05 ), whereas NOE administration significantly increased this marker ( p < 0.05 ). Moreover, NOE attenuated inflammation and alveolar injury in the lungs of OVA-sensitive rat compared to the nontreated A group. Conclusions. Overall, our findings demonstrated that NOE somewhat is able to reduce airway inflammation by reducing inflammatory and increasing GPX activity. Indeed, further experiments investigating the impact of different extract doses are needed to confirm the antioxidant and anti-inflammatory effects of NOE.

Inhalation of Spray-Dried Extract of <i>Salvia rosmarinus Spenn</i> Alleviates Lung Inflammatory, Oxidative, and Remodeling Changes in Asthmatic Rats

“…OS is linked to airway inflammation and asthma severity. Elevated oxidant indicators (NO and MDA) and decreased antioxidant parameters (TAC, SOD, and GPX) have been linked to asthma [26, 42]. Therefore, OS has a potential impact on the pathogenesis of asthma.…”

Myrtenol Ameliorates Recognition Memories’ Impairment and Anxiety-Like Behaviors Induced by Asthma by Mitigating Hippocampal Inflammation and Oxidative Stress in Rats

“…On days 0 and 7, ovalbumin (OVA, 1 mg) and aluminum hydroxide (200 μg) dissolved in 0.5 mL of sterile PBS was intraperitoneally injected into the asthmatic rats. The sensitized rats inhaled 1% aerosolized OVA (1 g OVA in 100 mL of sterile PBS in a nebulizer) for 30 min every other day from day 14 to day 42 in a closed chamber (30 × 50 × 60 cm) using a nebulizer [31,34,35]. The rat groups were the CTL group (with no interventions); asthma group (received just OVA); asthma/vehicle group 44 DOI: 10.1159/000528626 (asthmatic rats that received DMSO); asthma/myrtenol group (asthmatic rats that received myrtenol at a dose of 8 mg/kg); and asthma/budesonide group (asthmatic rats that received budesonide at a dose of 160 μg/kg) as a gold standard [36].…”

(R)-8-Methylsulfinyloctyl isothiocyanate from Nasturtium officinale inhibits LPS-induced immunoinflammatory responses in mouse peritoneal macrophages: chemical synthesis and molecular signaling pathways involved

“…Watercress as a medicinal plant has its origins in the ancient and traditional medicines of Iran, where it is used to treat pathologies such as renal colic, hypertension and hyperglycemia. 1 In the literature, the different biological activities of this plant extract are described, such as cardioprotective, 2,3 hypolipidemic, 4 anticancer, [5][6][7][8][9] antioxidant, 2,10-15 antiinflammatory, 10,12,[15][16][17] antidiabetic, 18 antibacterial, 19,20 antiallergic, 21 and antipsoriatic activities, 22 as well as its effects on the reproductive system. 23 In addition to its use as a medicinal substance, watercress has shown interesting activities in the field of cosmetics due to its anti-ageing, skin-brightening and anti-acne effects, in phytoremediation and at a nutritional level, because it is currently becoming one of the most interesting vegetables in healthy diet and in modern cuisine.…”

“…33,41 While several studies have described the anti-inflammatory and antioxidant effects of N. officinale, there is limited information on the pharmacological activity of (R)-8-OITC. [15][16][17] Considering that most probably all natural methylsulfinyl analogues exist as a single enantiomer with an R S absolute configuration, 42 we decided to focus on the study of the biological activity of (R)-8-OITC related to its anti-inflammatory effect.…”

“…Watercress as a medicinal plant has its origins in the ancient and traditional medicines of Iran, where it is used to treat pathologies such as renal colic, hypertension and hyperglycemia. 1 In the literature, the different biological activities of this plant extract are described, such as cardioprotective, 2,3 hypolipidemic, 4 anticancer, 5–9 antioxidant, 2,10–15 anti-inflammatory, 10,12,15–17 antidiabetic, 18 antibacterial, 19,20 antiallergic, 21 and antipsoriatic activities, 22 as well as its effects on the reproductive system. 23…”