The Hydrazine Moiety in the Synthesis of Modified Nucleosides and Nucleotides
Anaïs Guillou,
Suzanne Peyrottes,
Jean‐Jacques Vasseur
et al.
Abstract:Synthetic nucleoside mimics are re‐emerging as crucial contenders for antiviral and anticancer medications. While, Ribavirin stands out for its unique antiviral properties, predominantly associated with its distinctive triazole heterocycle as a nucleobase, the exploration of alternative nitrogen‐based aromatic heterocycles hold great promises for the discovery of novel bioactive nucleoside mimics. Although nucleoside derivatives synthesised from hydrazine‐ribose units have been in development for many decades,… Show more
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