The human β3 alcohol dehydrogenase subunit differs from β1 by a cys for Arg-369 substitution which decreases NAD(H) binding

Burnell, Joe C.; Carr, Lucinda G.; Dwulet, Francis E.; Edenberg, Howard J.; Li, Ting Kai; Bosron, William F.

doi:10.1016/0006-291x(87)90779-0

Cited by 52 publications

(30 citation statements)

References 14 publications

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“…In the present study, we found no subjects with the ADH1B Ã 3 allele, which is associated with decreased activity of ADH1B [Burnell et al, 1987]. This allele has been reported in African Americans [Thomasson et al, 1995] and Native Americans [Wall [Higuchi, 1994].…”

Section: Discussionmentioning

confidence: 59%

Impact of theAlcohol-Dehydrogenase(ADH)1CandADH1Bpolymorphisms on drinking behavior in nonalcoholic Japanese

et al. 2007

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A linkage disequilibrium (LD) between the alcohol-dehydrogenase 1B (ADH1B) and alcohol-dehydrogenase 1C (ADH1C) polymorphisms adds complexity to differentiating the significance of these two genetic polymorphisms on drinking behavior and alcoholism. We have recently shown the importance of the ADH1B polymorphism on habitual drinking in the Japanese population; however, the issue regarding the LD between the ADH1B and ADH1C polymorphisms remains to be clarified. Here, we conducted a cross-sectional study in 2,299 nonalcoholic Japanese individuals. Drinking behavior was examined with regard to haplotypes of the ADH1B and ADH1C polymorphisms. Strength of association was assessed by sex and aldehyde-dehydrogenase 2 (ALDH2) adjusted odds ratios (OR) and their 95% confidence intervals (CIs) for the haplotype of the ADH1B and ADH1C polymorphisms. The ORs for habitual drinking were significant for ADH1B*2(rapid)-ADH1C*2(slow) (OR = 1.03; 95% CI: 1.01-1.05), ADH1B*1(slow)-ADH1C*1(rapid) (OR = 1.15; 95% CI: 1.14-1.16), and ADH1B*1(slow)-ADH1C*2(slow) (OR = 1.31; 95% CI: 1.29-1.32) compared with ADH1B*2(rapid)-ADH1C*1(rapid). This trend was evident among males. Similarly, a significantly increased risk of heavy drinking was observed for each haplotype compared with ADH1B*2(rapid)-ADH1C*1(rapid). In conclusion, this study showed a significant impact of the ADH1C polymorphism on habitual drinking, regardless of the ADH1B/ALDH2 polymorphisms.

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Section: Discussionmentioning

confidence: 59%

Impact of theAlcohol-Dehydrogenase(ADH)1CandADH1Bpolymorphisms on drinking behavior in nonalcoholic Japanese

et al. 2007

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“…b Cohen et al 1992Nakagawa et al 1993;Clot et al 1994;Nebert et al 1996;Nelson et al 1996;Parkinson 1996;Marez et al 1997. c Burnell et al 1987;Edman & Maret 1992;Zgombic-Knight et al 1995. d Goedde et al 1992;Hsu et al 1997;Yoshida et al 1998. e Jaiswal et al 1990;Rosvold et al 1995;Yao et al 1996.…”

Section: Genetic Variation and Function Of The Immune And Detoxicatiounclassified

Good genes, oxidative stress and condition–dependent sexual signals

Schantz

Bensch

Grahn

et al. 1999

Proc. R. Soc. Lond. B

747

766

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The immune and the detoxication systems of animals are characterized by allelic polymorphisms, which underlie individual di¡erences in ability to combat assaults from pathogens and toxic compounds. Previous studies have shown that females may improve o¡spring survival by selecting mates on the basis of sexual ornaments and signals that honestly reveal health. In many cases the expression of these ornaments appears to be particularly sensitive to oxidative stress. Activated immune and detoxication systems often generate oxidative stress by an extensive production of reactive metabolites and free radicals. Given that tolerance or resistance to toxic compounds and pathogens can be inherited, female choice should promote the evolution of male ornaments that reliably reveal the status of the bearers' level of oxidative stress. Hence, oxidative stress may be one important agent linking the expression of sexual ornaments to genetic variation in ¢tness-related traits, thus promoting the evolution of female mate choice and male sexual ornamentation, a controversial issue in evolutionary biology ever since Darwin.

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“…This mutation in the active site has lead to the change of kinetic and functional properties such as different pH optimum and Vmax of the atypical type of ADH. Amino acid analysis of *1, *2 and ,*3 subunits indicated that the substitution of Arg of *1 and *2 at the 47th residue occurs and *3 has Cys at the 369th position (BURNELL et al, 1987). Amino acid sequences of the *1 and *2 subunits have the same ones except to replacements at position 271(Arg/Gln) and 349 (IIe/Val) (BUHLER et al, 1984;HEMPEL et al, 1985a).…”

Section: ) Adhmentioning

confidence: 90%

Genetic Polymorphism of Alcohol Metabolyzing Enzymes and Its Implication to Human Ecology.

Harada

1991

Journal of Anthropological Society of Nippon

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Individual and racial differences in alcohol metabolism and their implications in acute and chronic intoxication of alcohol intake were reviewed in the relationships of genetic polymorphism of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). The recent studies revealed that the catalytic deficiency of ALDH2 isozyme is responsible to the flushing symptom as well as other vasomotor symptoms caused by a higher acetaldehyde level after alcohol consumption. Subsequently the deficiency of ALDH2 has been prevalently found among only the peoples of Mongoloid origin and the individuals deficient in ALDH2 refrain from excessive drinking of alcohol due to averse reaction leading to protection against alcoholism. Moreover, many studies based on DNA analysis have confirmed these findings. As ALDH2 polymorphism was found only in Mongoloid, population studies on the ALDH2 mutant will provide the important information to estimate the dispersal of the ethnic groups in Asia and Oceania and also to prevent alcohol abuse in the developing countries.

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The human β3 alcohol dehydrogenase subunit differs from β1 by a cys for Arg-369 substitution which decreases NAD(H) binding

Cited by 52 publications

References 14 publications

Impact of theAlcohol-Dehydrogenase(ADH)1CandADH1Bpolymorphisms on drinking behavior in nonalcoholic Japanese

Impact of theAlcohol-Dehydrogenase(ADH)1CandADH1Bpolymorphisms on drinking behavior in nonalcoholic Japanese

Good genes, oxidative stress and condition–dependent sexual signals

Genetic Polymorphism of Alcohol Metabolyzing Enzymes and Its Implication to Human Ecology.

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